Gene description for TAB1
Gene name TGF-beta activated kinase 1/MAP3K7 binding protein 1
Gene symbol TAB1
Other names/aliases 3'-Tab1
MAP3K7IP1
Species Homo sapiens
 Database cross references - TAB1
ExoCarta ExoCarta_10454
Vesiclepedia VP_10454
Entrez Gene 10454
HGNC 18157
MIM 602615
UniProt Q15750  
 TAB1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TAB1
Molecular Function
    protein serine/threonine phosphatase activity GO:0004722 IEA
    protein binding GO:0005515 IPI
    protein serine/threonine kinase activator activity GO:0043539 IDA
    protein-containing complex binding GO:0044877 IEA
    mitogen-activated protein kinase p38 binding GO:0048273 IEA
    molecular adaptor activity GO:0060090 IDA
Biological Process
    in utero embryonic development GO:0001701 IEA
    heart morphogenesis GO:0003007 IEA
    cardiac septum development GO:0003279 IEA
    signal transduction GO:0007165 IBA
    transforming growth factor beta receptor signaling pathway GO:0007179 IEA
    lung development GO:0030324 IEA
    aorta development GO:0035904 IEA
    non-canonical NF-kappaB signal transduction GO:0038061 IDA
    positive regulation of MAPK cascade GO:0043410 IEA
    coronary vasculature development GO:0060976 IEA
    positive regulation of protein serine/threonine kinase activity GO:0071902 IDA
    positive regulation of cGAS/STING signaling pathway GO:0141111 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    endosome membrane GO:0010008 TAS
    nuclear speck GO:0016607 IDA
    protein-containing complex GO:0032991 IEA
 Experiment description of studies that identified TAB1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TAB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 ISG15 9636
Affinity Capture-MS Homo sapiens
3 XIAP  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
4 TH  
Affinity Capture-MS Homo sapiens
5 C9orf78 51759
Two-hybrid Homo sapiens
6 RACGAP1 29127
Affinity Capture-MS Homo sapiens
7 YWHAE 7531
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
8 LAP3 51056
Two-hybrid Homo sapiens
9 PCDHGB4 8641
Affinity Capture-MS Homo sapiens
10 DBN1 1627
Two-hybrid Homo sapiens
11 F2R 2149
Affinity Capture-Western Homo sapiens
12 HSPA1L 3305
Co-localization Homo sapiens
13 S100A10 6281
Affinity Capture-MS Homo sapiens
14 RPL10 6134
Two-hybrid Homo sapiens
15 ARHGAP11B  
Affinity Capture-MS Homo sapiens
16 MON1A 84315
Two-hybrid Homo sapiens
17 UBC 7316
Reconstituted Complex Homo sapiens
18 HSP90AB1 3326
Co-fractionation Homo sapiens
19 NAIP  
Affinity Capture-Western Homo sapiens
20 HNRNPR 10236
Two-hybrid Homo sapiens
21 CFL1 1072
Two-hybrid Homo sapiens
22 LCMT1 51451
Two-hybrid Homo sapiens
23 PARK7 11315
Affinity Capture-MS Homo sapiens
24 CCDC102B  
Affinity Capture-MS Homo sapiens
25 CKB 1152
Two-hybrid Homo sapiens
26 KIAA1429 25962
Affinity Capture-MS Homo sapiens
27 Rrp1b 72462
Affinity Capture-MS Mus musculus
28 CAPZB 832
Affinity Capture-MS Homo sapiens
29 RFPL4B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 EMILIN1 11117
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 MDM2  
Affinity Capture-Western Homo sapiens
32 MCM2 4171
Affinity Capture-MS Homo sapiens
33 PTPMT1 114971
Two-hybrid Homo sapiens
34 WDR83  
Affinity Capture-MS Homo sapiens
35 NR2C2  
Two-hybrid Homo sapiens
36 CARD8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 USP18  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
38 B4GALT2  
Affinity Capture-MS Homo sapiens
39 AGO3  
Affinity Capture-MS Homo sapiens
40 PPP1R7 5510
Two-hybrid Homo sapiens
41 ZMYND11 10771
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
42 MAPK14 1432
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
43 MICAL1 64780
Two-hybrid Homo sapiens
44 XPO7 23039
Two-hybrid Homo sapiens
45 C2orf44  
Two-hybrid Homo sapiens
46 NR4A1  
Affinity Capture-MS Homo sapiens
47 MAPK11  
Co-localization Homo sapiens
48 F10 2159
Affinity Capture-MS Homo sapiens
49 RIPK2  
Affinity Capture-Western Homo sapiens
50 SNX27 81609
Affinity Capture-MS Homo sapiens
51 ASRGL1 80150
Two-hybrid Homo sapiens
52 ARHGAP9 64333
Affinity Capture-MS Homo sapiens
53 SOD1 6647
Affinity Capture-MS Homo sapiens
54 PSMC3 5702
Affinity Capture-MS Homo sapiens
55 HSPA8 3312
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 TNF  
Affinity Capture-MS Homo sapiens
57 HSPBP1 23640
Affinity Capture-MS Homo sapiens
58 XPO1 7514
Affinity Capture-MS Homo sapiens
59 CAMK2A 815
Affinity Capture-MS Homo sapiens
60 TRIM24  
Affinity Capture-MS Homo sapiens
61 VRK3 51231
Affinity Capture-MS Homo sapiens
62 MANSC1 54682
Affinity Capture-MS Homo sapiens
63 SULT1C4  
Affinity Capture-MS Homo sapiens
64 MTMR8  
Affinity Capture-MS Homo sapiens
65 MIB1 57534
Proximity Label-MS Homo sapiens
66 USP10 9100
Affinity Capture-MS Homo sapiens
67 RBX1 9978
Two-hybrid Homo sapiens
68 MAPK12  
Affinity Capture-Western Homo sapiens
69 PARK2  
Affinity Capture-MS Homo sapiens
70 TAB3 257397
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 PSMD14 10213
Affinity Capture-MS Homo sapiens
72 MAPK8IP1 9479
Co-fractionation Homo sapiens
73 DIABLO 56616
Proximity Label-MS Homo sapiens
74 CYB5A 1528
Affinity Capture-MS Homo sapiens
75 C9orf41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 OGT 8473
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
77 CASP6 839
Two-hybrid Homo sapiens
78 SYNC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 IFI16 3428
Affinity Capture-MS Homo sapiens
80 ALKBH3  
Affinity Capture-MS Homo sapiens
81 POLDIP2 26073
Two-hybrid Homo sapiens
82 BICD2 23299
Proximity Label-MS Homo sapiens
83 PRMT2  
Affinity Capture-MS Homo sapiens
84 RPLP1 6176
Two-hybrid Homo sapiens
85 GANAB 23193
Affinity Capture-MS Homo sapiens
86 ITCH 83737
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
87 PRKAR1A 5573
Two-hybrid Homo sapiens
88 CYLD  
Affinity Capture-MS Homo sapiens
89 TIRAP  
Affinity Capture-Western Homo sapiens
90 YAP1 10413
Affinity Capture-MS Homo sapiens
91 MTG2  
Two-hybrid Homo sapiens
92 TMEM52B 120939
Affinity Capture-MS Homo sapiens
93 CCL22 6367
Affinity Capture-MS Homo sapiens
94 SCRN1 9805
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 RDH14 57665
Affinity Capture-MS Homo sapiens
96 PCDH20  
Affinity Capture-MS Homo sapiens
97 KIFC2  
Two-hybrid Homo sapiens
98 C11orf70  
Affinity Capture-MS Homo sapiens
99 SNRNP35  
Two-hybrid Homo sapiens
100 BAG2 9532
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 OCRL 4952
Affinity Capture-MS Homo sapiens
102 CARD11  
Two-hybrid Homo sapiens
103 TRIP6 7205
Two-hybrid Homo sapiens
104 TAB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
105 PRKCZ 5590
Affinity Capture-MS Homo sapiens
106 TRAF6 7189
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
107 ERBB4 2066
Two-hybrid Homo sapiens
108 EGFR 1956
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
109 CDK5RAP3 80279
Two-hybrid Homo sapiens
110 MAP3K1 4214
Biochemical Activity Homo sapiens
111 ARHGEF16 27237
Affinity Capture-MS Homo sapiens
112 TSSC4  
Two-hybrid Homo sapiens
113 EPRS 2058
Two-hybrid Homo sapiens
114 MORF4L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 MAP3K7  
Affinity Capture-Western Homo sapiens
Phenotypic Enhancement Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
116 FN1 2335
Two-hybrid Homo sapiens
117 NXF1 10482
Affinity Capture-RNA Homo sapiens
118 CRYBB3  
Affinity Capture-MS Homo sapiens
119 KCNE3  
Affinity Capture-MS Homo sapiens
120 ZMYM6  
Affinity Capture-MS Homo sapiens
121 IFI35 3430
Affinity Capture-MS Homo sapiens
122 PPP2R1A 5518
Two-hybrid Homo sapiens
123 MAPKAPK5 8550
Two-hybrid Homo sapiens
124 GIT1 28964
Two-hybrid Homo sapiens
125 HSPA1A 3303
Affinity Capture-MS Homo sapiens
126 CORO1A 11151
Two-hybrid Homo sapiens
127 BICD1 636
Proximity Label-MS Homo sapiens
128 KLHL10  
Affinity Capture-MS Homo sapiens
129 NXPH3  
Two-hybrid Homo sapiens
130 SMAD6  
Affinity Capture-Western Homo sapiens
131 SEH1L 81929
Affinity Capture-MS Homo sapiens
132 TMEM74  
Affinity Capture-MS Homo sapiens
133 PPP2CB 5516
Two-hybrid Homo sapiens
134 FARP1 10160
Affinity Capture-MS Homo sapiens
135 ARAP1 116985
Two-hybrid Homo sapiens
136 GRK5 2869
Affinity Capture-MS Homo sapiens
137 ARRB2 409
Affinity Capture-MS Homo sapiens
138 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
139 AATK  
Two-hybrid Homo sapiens
140 Arhgap33  
Affinity Capture-MS Mus musculus
141 TRAF2 7186
Affinity Capture-MS Homo sapiens
142 SLMAP 7871
Proximity Label-MS Homo sapiens
143 GRB2 2885
Affinity Capture-MS Homo sapiens
144 SMAD7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
145 PDCD6IP 10015
Two-hybrid Homo sapiens
146 CDC37 11140
Affinity Capture-MS Homo sapiens
147 IKBKG 8517
Reconstituted Complex Homo sapiens
148 SMURF1 57154
Biochemical Activity Homo sapiens
149 SQSTM1 8878
Proximity Label-MS Homo sapiens
150 URB1 9875
Two-hybrid Homo sapiens
151 MORF4L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 WTAP 9589
Two-hybrid Homo sapiens
153 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
154 SHMT2 6472
Affinity Capture-RNA Homo sapiens
155 MAMDC2 256691
Affinity Capture-MS Homo sapiens
156 FADD 8772
Two-hybrid Homo sapiens
157 AARSD1 80755
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
158 ROR2 4920
Two-hybrid Homo sapiens
159 ESR1  
Affinity Capture-MS Homo sapiens
160 UFL1 23376
Affinity Capture-MS Homo sapiens
161 C6orf141  
Affinity Capture-MS Homo sapiens
162 ACAP3 116983
Two-hybrid Homo sapiens
163 ITSN2 50618
Affinity Capture-MS Homo sapiens
164 MAGED1 9500
Affinity Capture-Western Homo sapiens
165 MOV10 4343
Affinity Capture-RNA Homo sapiens
166 TBL1Y  
Affinity Capture-MS Homo sapiens
167 ARHGAP36  
Affinity Capture-MS Homo sapiens
168 POLR3D  
Two-hybrid Homo sapiens
169 PHACTR3  
Two-hybrid Homo sapiens
170 SERPINB2 5055
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
171 Map3k7  
Reconstituted Complex Mus musculus
172 ARHGAP23 57636
Affinity Capture-MS Homo sapiens
173 PHC2  
Two-hybrid Homo sapiens
174 BIRC7  
Affinity Capture-Western Homo sapiens
175 RC3H1 149041
Affinity Capture-MS Homo sapiens
176 GGT1 2678
Affinity Capture-MS Homo sapiens
177 SERPINA4 5267
Two-hybrid Homo sapiens
178 IKBKB 3551
Affinity Capture-Western Homo sapiens
179 PRMT1 3276
Affinity Capture-MS Homo sapiens
180 NOTCH1 4851
Affinity Capture-MS Homo sapiens
181 TRPC4AP  
Two-hybrid Homo sapiens
182 BST2 684
Affinity Capture-Western Homo sapiens
View the network image/svg+xml