Gene description for TAB1
Gene name TGF-beta activated kinase 1/MAP3K7 binding protein 1
Gene symbol TAB1
Other names/aliases 3'-Tab1
MAP3K7IP1
Species Homo sapiens
 Database cross references - TAB1
ExoCarta ExoCarta_10454
Vesiclepedia VP_10454
Entrez Gene 10454
HGNC 18157
MIM 602615
UniProt Q15750  
 TAB1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TAB1
Molecular Function
    catalytic activity GO:0003824 IEA
    mitogen-activated protein kinase p38 binding GO:0048273 IEA
    enzyme activator activity GO:0008047 TAS
    protein complex binding GO:0032403 IEA
    protein binding GO:0005515 IPI
    kinase activator activity GO:0019209 IEA
Biological Process
    MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS
    toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS
    stress-activated MAPK cascade GO:0051403 TAS
    nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0035872 TAS
    heart morphogenesis GO:0003007 IEA
    activation of MAPKKK activity GO:0000185 IEA
    toll-like receptor 4 signaling pathway GO:0034142 TAS
    in utero embryonic development GO:0001701 IEA
    toll-like receptor 9 signaling pathway GO:0034162 TAS
    transforming growth factor beta receptor signaling pathway GO:0007179 IEA
    toll-like receptor 5 signaling pathway GO:0034146 TAS
    JNK cascade GO:0007254 TAS
    activation of MAPK activity GO:0000187 TAS
    stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS
    I-kappaB kinase/NF-kappaB signaling GO:0007249 TAS
    TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS
    toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS
    toll-like receptor 2 signaling pathway GO:0034134 TAS
    lung development GO:0030324 IEA
    toll-like receptor 3 signaling pathway GO:0034138 TAS
    nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 TAS
    MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS
    positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    innate immune response GO:0045087 TAS
    toll-like receptor signaling pathway GO:0002224 TAS
    toll-like receptor 10 signaling pathway GO:0034166 TAS
Subcellular Localization
    endosome membrane GO:0010008 TAS
    cytosol GO:0005829 TAS
    protein complex GO:0043234 IEA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified TAB1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TAB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SMAD6  
Affinity Capture-Western Homo sapiens
2 MAPK14 1432
Invitro Homo sapiens
3 TRAF6 7189
Invivo Homo sapiens
4 XIAP  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
5 TRAF2 7186
Affinity Capture-MS Homo sapiens
6 BMPR1A 657
Invivo Homo sapiens
Two-hybrid Homo sapiens
7 SMAD7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
8 TAB3 257397
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 MAP3K7IP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
10 MAP3K7  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
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