Gene description for ASRGL1
Gene name asparaginase like 1
Gene symbol ASRGL1
Other names/aliases ALP
ALP1
CRASH
Species Homo sapiens
 Database cross references - ASRGL1
ExoCarta ExoCarta_80150
Entrez Gene 80150
HGNC 16448
MIM 609212
UniProt Q7L266  
 ASRGL1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ASRGL1
Molecular Function
    asparaginase activity GO:0004067 IDA
    beta-aspartyl-peptidase activity GO:0008798 IDA
    N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity GO:0003948 IDA
Biological Process
    asparagine catabolic process via L-aspartate GO:0033345 ISS
    proteolysis GO:0006508 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified ASRGL1 in exosomes
1
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ASRGL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ASRGL1 is involved
No pathways found





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