Gene description for PROSC
Gene name proline synthetase co-transcribed homolog (bacterial)
Gene symbol PROSC
Other names/aliases -
Species Homo sapiens
 Database cross references - PROSC
ExoCarta ExoCarta_11212
Vesiclepedia VP_11212
Entrez Gene 11212
HGNC 9457
MIM 604436
UniProt O94903  
 PROSC identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PROSC
Molecular Function
    pyridoxal phosphate binding GO:0030170 IBA
Biological Process
    vitamin B6 metabolic process GO:0042816 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 NAS
    mitochondrion GO:0005739 HTP
    cytosol GO:0005829 IDA
 Experiment description of studies that identified PROSC in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PROSC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ADRBK1 156
Co-fractionation Homo sapiens
2 Sgol2  
Affinity Capture-MS Mus musculus
3 TWF2 11344
Co-fractionation Homo sapiens
4 OGFOD1  
Co-fractionation Homo sapiens
5 PTMA 5757
Co-fractionation Homo sapiens
6 YWHAE 7531
Co-fractionation Homo sapiens
7 ANAPC15  
Affinity Capture-MS Homo sapiens
8 DDX17 10521
Co-fractionation Homo sapiens
9 CFC1  
Affinity Capture-MS Homo sapiens
10 OXNAD1 92106
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 KDM4A  
Affinity Capture-MS Homo sapiens
12 SOX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SBDS 51119
Co-fractionation Homo sapiens
14 CMBL 134147
Affinity Capture-MS Homo sapiens
15 Tgs1  
Affinity Capture-MS Mus musculus
16 NDUFS3 4722
Affinity Capture-MS Homo sapiens
17 TBCB 1155
Co-fractionation Homo sapiens
18 MCM2 4171
Affinity Capture-MS Homo sapiens
19 UBE2K 3093
Co-fractionation Homo sapiens
20 MCTS1 28985
Co-fractionation Homo sapiens
21 HEXB 3074
Co-fractionation Homo sapiens
22 FMNL2 114793
Affinity Capture-MS Homo sapiens
23 Klc2  
Affinity Capture-MS Mus musculus
24 Cbx4  
Affinity Capture-MS Mus musculus
25 TATDN1 83940
Co-fractionation Homo sapiens
26 NAGK 55577
Co-fractionation Homo sapiens
27 HK1 3098
Co-fractionation Homo sapiens
28 SRSF6 6431
Affinity Capture-MS Homo sapiens
29 NAE1 8883
Co-fractionation Homo sapiens
30 ENSA 2029
Co-fractionation Homo sapiens
31 ALDH16A1 126133
Co-fractionation Homo sapiens
32 ISOC1 51015
Co-fractionation Homo sapiens
33 PCK2 5106
Affinity Capture-MS Homo sapiens
34 ADI1 55256
Co-fractionation Homo sapiens
35 TUFM 7284
Co-fractionation Homo sapiens
36 SLX4  
Affinity Capture-MS Homo sapiens
37 KDM5B  
Affinity Capture-MS Homo sapiens
38 CENPM  
Affinity Capture-MS Homo sapiens
39 CDK5R1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 CHORDC1 26973
Affinity Capture-MS Homo sapiens
41 ATIC 471
Co-fractionation Homo sapiens
42 SMS 6611
Co-fractionation Homo sapiens
43 ARHGAP36  
Affinity Capture-MS Homo sapiens
44 HNRNPA3 220988
Co-fractionation Homo sapiens
45 CARS 833
Co-fractionation Homo sapiens
46 FRMPD2  
Affinity Capture-MS Homo sapiens
47 S100P 6286
Co-fractionation Homo sapiens
48 GGH 8836
Affinity Capture-MS Homo sapiens
49 SLC25A32 81034
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 PRCP 5547
Co-fractionation Homo sapiens
51 ASB6 140459
Co-fractionation Homo sapiens
52 PHPT1 29085
Co-fractionation Homo sapiens
53 FAHD1 81889
Affinity Capture-MS Homo sapiens
54 EIF4E 1977
Co-fractionation Homo sapiens
55 GTF3C4 9329
Co-fractionation Homo sapiens
56 ARFIP1 27236
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
57 TOMM70A 9868
Co-fractionation Homo sapiens
58 DYX1C1  
Affinity Capture-MS Homo sapiens
59 HNRNPA1 3178
Co-fractionation Homo sapiens
60 Sesn2  
Affinity Capture-MS Mus musculus
61 MYEF2 50804
Co-fractionation Homo sapiens
62 MOB2 81532
Affinity Capture-MS Homo sapiens
63 TMEM101  
Affinity Capture-MS Homo sapiens
64 ASRGL1 80150
Co-fractionation Homo sapiens
65 Cdca5  
Affinity Capture-MS Mus musculus
66 UBXN1 51035
Co-fractionation Homo sapiens
67 FARP1 10160
Affinity Capture-MS Homo sapiens
68 PHGDH 26227
Co-fractionation Homo sapiens
69 SATB1 6304
Affinity Capture-MS Homo sapiens
70 GSR 2936
Co-fractionation Homo sapiens
71 AHSA1 10598
Co-fractionation Homo sapiens
72 SH3PXD2B 285590
Co-fractionation Homo sapiens
73 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
74 PAPOLA 10914
Co-fractionation Homo sapiens
75 ASNS 440
Co-fractionation Homo sapiens
76 PDIA4 9601
Co-fractionation Homo sapiens
77 PAFAH1B2 5049
Co-fractionation Homo sapiens
78 NME4 4833
Affinity Capture-MS Homo sapiens
79 NUDT13  
Affinity Capture-MS Homo sapiens
80 RPA1 6117
Affinity Capture-MS Homo sapiens
81 YARS 8565
Co-fractionation Homo sapiens
82 FCGR2A 2212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 CAPNS1 826
Co-fractionation Homo sapiens
84 STK26 51765
Co-fractionation Homo sapiens
85 STK38L 23012
Affinity Capture-MS Homo sapiens
86 TRA2B 6434
Affinity Capture-MS Homo sapiens
87 POU2F1 5451
Co-fractionation Homo sapiens
88 RAVER1 125950
Co-fractionation Homo sapiens
89 Srsf1 110809
Affinity Capture-MS Mus musculus
90 LSM7  
Affinity Capture-MS Homo sapiens
91 PPP1R2 5504
Co-fractionation Homo sapiens
92 PARD6B 84612
Affinity Capture-MS Homo sapiens
93 DNAJB4 11080
Co-fractionation Homo sapiens
94 MYO1E 4643
Co-fractionation Homo sapiens
95 SUMO3 6612
Co-fractionation Homo sapiens
96 GPX7 2882
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 PRMT1 3276
Affinity Capture-MS Homo sapiens
98 CAPN2 824
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which PROSC is involved
No pathways found





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