Gene description for MOB2
Gene name MOB kinase activator 2
Gene symbol MOB2
Other names/aliases HCCA2
Species Homo sapiens
 Database cross references - MOB2
ExoCarta ExoCarta_81532
Vesiclepedia VP_81532
Entrez Gene 81532
HGNC 24904
MIM 611969
UniProt Q70IA6  
 MOB2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for MOB2
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase activator activity GO:0030295 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    signal transduction GO:0007165 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified MOB2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MOB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LAMTOR5 10542
Affinity Capture-MS Homo sapiens
2 DEPDC1B 55789
Affinity Capture-MS Homo sapiens
3 UBE2H 7328
Affinity Capture-MS Homo sapiens
4 MOB1B 92597
Proximity Label-MS Homo sapiens
5 ESR1  
Affinity Capture-MS Homo sapiens
6 ARHGAP11B  
Affinity Capture-MS Homo sapiens
7 SFT2D2 375035
Two-hybrid Homo sapiens
8 RACGAP1 29127
Affinity Capture-MS Homo sapiens
9 STK38 11329
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
10 ACTA2 59
Affinity Capture-MS Homo sapiens
11 UFL1 23376
Affinity Capture-MS Homo sapiens
12 VRK3 51231
Affinity Capture-MS Homo sapiens
13 MIIP 60672
Two-hybrid Homo sapiens
14 C1orf86  
Two-hybrid Homo sapiens
15 OR5H1  
Two-hybrid Homo sapiens
16 COX15 1355
Affinity Capture-MS Homo sapiens
17 EIF4A3 9775
Affinity Capture-MS Homo sapiens
18 DDX58 23586
Affinity Capture-RNA Homo sapiens
19 CDK1 983
Affinity Capture-MS Homo sapiens
20 CCDC90B  
Two-hybrid Homo sapiens
21 SCYL2 55681
Affinity Capture-MS Homo sapiens
22 TRIM24  
Affinity Capture-MS Homo sapiens
23 COQ2  
Affinity Capture-MS Homo sapiens
24 Myo9b  
Affinity Capture-MS Rattus norvegicus
25 SOAT1 6646
Affinity Capture-MS Homo sapiens
26 FAM134C 162427
Two-hybrid Homo sapiens
27 NRD1 4898
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
28 MYH9 4627
Affinity Capture-MS Homo sapiens
29 WDYHV1  
Two-hybrid Homo sapiens
30 PFKFB2 5208
Affinity Capture-MS Homo sapiens
31 FRA10AC1 118924
Two-hybrid Homo sapiens
32 STK38L 23012
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
33 PPM1A 5494
Affinity Capture-MS Homo sapiens
34 NAP1L5  
Affinity Capture-MS Homo sapiens
35 Arhgap18  
Affinity Capture-MS Mus musculus
36 MYH10 4628
Affinity Capture-MS Homo sapiens
37 PIK3R1 5295
Affinity Capture-MS Homo sapiens
38 Stk38 106504
Affinity Capture-MS Mus musculus
39 MOB1A 55233
Proximity Label-MS Homo sapiens
40 MAGOH 4116
Affinity Capture-MS Homo sapiens
41 ARHGAP35 2909
Affinity Capture-MS Homo sapiens
42 PDF  
Affinity Capture-MS Homo sapiens
43 ATG3 64422
Two-hybrid Homo sapiens
44 MYL12B 103910
Affinity Capture-MS Homo sapiens
45 VDAC1 7416
Affinity Capture-MS Homo sapiens
46 PROSC 11212
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MOB2 is involved
No pathways found





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