Gene description for PPM1A
Gene name protein phosphatase, Mg2+/Mn2+ dependent, 1A
Gene symbol PPM1A
Other names/aliases PP2C-ALPHA
PP2CA
PP2Calpha
Species Homo sapiens
 Database cross references - PPM1A
ExoCarta ExoCarta_5494
Vesiclepedia VP_5494
Entrez Gene 5494
HGNC 9275
MIM 606108
UniProt P35813  
 PPM1A identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for PPM1A
Molecular Function
    magnesium ion binding GO:0000287 IEA
    protein serine/threonine phosphatase activity GO:0004722 IBA
    protein serine/threonine phosphatase activity GO:0004722 IDA
    protein serine/threonine phosphatase activity GO:0004722 TAS
    protein binding GO:0005515 IPI
    myosin phosphatase activity GO:0017018 IEA
    manganese ion binding GO:0030145 IEA
    calmodulin-dependent protein phosphatase activity GO:0033192 IDA
    R-SMAD binding GO:0070412 IPI
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 TAS
    chromatin remodeling GO:0006338 IEA
    protein dephosphorylation GO:0006470 IMP
    N-terminal protein myristoylation GO:0006499 ISS
    protein export from nucleus GO:0006611 IEA
    dephosphorylation GO:0016311 IDA
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IDA
    negative regulation of BMP signaling pathway GO:0030514 IEA
    peptidyl-threonine dephosphorylation GO:0035970 IDA
    regulation of canonical NF-kappaB signal transduction GO:0043122 IBA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 HMP
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IMP
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of protein export from nucleus GO:0046827 IEA
    regulation of cell cycle GO:0051726 TAS
    cellular response to transforming growth factor beta stimulus GO:0071560 IEA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IBA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IDA
    negative regulation of non-canonical NF-kappaB signal transduction GO:1901223 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISS
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 ISS
 Experiment description of studies that identified PPM1A in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPM1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Csnk1d  
Affinity Capture-MS Mus musculus
2 SLFN11 91607
Affinity Capture-MS Homo sapiens
3 PRKAA1 5562
Biochemical Activity Homo sapiens
4 CABP2  
Affinity Capture-MS Homo sapiens
5 CDC42BPB 9578
Biochemical Activity Homo sapiens
6 BCKDK 10295
Affinity Capture-MS Homo sapiens
7 DCP1B  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
8 GJA1 2697
Affinity Capture-MS Homo sapiens
9 RNASE13  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 EPB41L5 57669
Affinity Capture-MS Homo sapiens
11 PAK2 5062
Biochemical Activity Homo sapiens
12 DYNC1I1  
Proximity Label-MS Homo sapiens
13 HSPB1 3315
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
14 IL20  
Affinity Capture-MS Homo sapiens
15 HSFY1  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
16 CHST10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 DUSP12 11266
Affinity Capture-MS Homo sapiens
18 PLOD3 8985
Co-fractionation Homo sapiens
19 PAK4 10298
Affinity Capture-MS Homo sapiens
20 MOB2 81532
Affinity Capture-MS Homo sapiens
21 RAB40C 57799
Affinity Capture-MS Homo sapiens
22 CERKL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ZDHHC11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CPSF7 79869
Co-fractionation Homo sapiens
25 PPP1R7 5510
Co-fractionation Homo sapiens
26 MAP4K5 11183
Co-fractionation Homo sapiens
27 QARS 5859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 KDR  
Two-hybrid Homo sapiens
29 ALK 238
Two-hybrid Homo sapiens
30 PTK7 5754
Two-hybrid Homo sapiens
31 HSD17B4 3295
Affinity Capture-MS Homo sapiens
32 RAD50 10111
Co-fractionation Homo sapiens
33 WFDC11  
Affinity Capture-MS Homo sapiens
34 ERBB2 2064
Two-hybrid Homo sapiens
35 SOD1 6647
Affinity Capture-MS Homo sapiens
36 PRNP 5621
Affinity Capture-MS Homo sapiens
37 PRAMEF5  
Affinity Capture-MS Homo sapiens
38 PAK1 5058
Biochemical Activity Homo sapiens
39 RBMX 27316
Co-fractionation Homo sapiens
40 PPM1B 5495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 PPP1CA 5499
Co-fractionation Homo sapiens
42 IGF1R 3480
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
43 ERBB3 2065
Two-hybrid Homo sapiens
44 PPIH 10465
Co-fractionation Homo sapiens
45 IWS1  
Affinity Capture-MS Homo sapiens
46 HAO2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 NAA10 8260
Co-fractionation Homo sapiens
48 CHEK1  
Co-fractionation Homo sapiens
49 ALDH3B1 221
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 PKN1 5585
Co-fractionation Homo sapiens
51 GRM3 2913
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
52 PIGS 94005
Affinity Capture-MS Homo sapiens
53 RPLP0 6175
Two-hybrid Homo sapiens
54 INSL6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 GDF3 9573
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 CYLD  
Affinity Capture-MS Homo sapiens
57 RTEL1 51750
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 DUSP22  
Affinity Capture-MS Homo sapiens
59 ARRB1 408
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
60 HNRNPD 3184
Affinity Capture-MS Homo sapiens
61 CCL22 6367
Affinity Capture-MS Homo sapiens
62 TECPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 NR4A1  
Two-hybrid Homo sapiens
64 UGGT1 56886
Affinity Capture-MS Homo sapiens
65 LXN 56925
Affinity Capture-MS Homo sapiens
66 IL25  
Affinity Capture-MS Homo sapiens
67 LETM1 3954
Affinity Capture-MS Homo sapiens
68 LMTK2 22853
Two-hybrid Homo sapiens
69 ERBB4 2066
Two-hybrid Homo sapiens
70 SPINK14  
Affinity Capture-MS Homo sapiens
71 EGFR 1956
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
72 NUP43 348995
Proximity Label-MS Homo sapiens
73 HIP1R 9026
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 PRKCI 5584
Co-fractionation Homo sapiens
75 SMAD1 4086
Affinity Capture-Western Homo sapiens
76 AATK  
Two-hybrid Homo sapiens
77 CDC42BPA 8476
Biochemical Activity Homo sapiens
78 FGFR2 2263
Two-hybrid Homo sapiens
79 SOAT1 6646
Affinity Capture-MS Homo sapiens
80 ACTR5 79913
Affinity Capture-MS Homo sapiens
81 RPA3 6119
Proximity Label-MS Homo sapiens
82 GCN1L1 10985
Affinity Capture-MS Homo sapiens
83 HSDL2 84263
Affinity Capture-MS Homo sapiens
84 PLA2G2D  
Affinity Capture-MS Homo sapiens
85 HSPA4 3308
Co-fractionation Homo sapiens
86 BICD1 636
Proximity Label-MS Homo sapiens
87 SGTA 6449
Proximity Label-MS Homo sapiens
88 VDAC1 7416
Affinity Capture-MS Homo sapiens
89 AKT1 207
Co-localization Homo sapiens
90 MTERF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 C9orf72  
Affinity Capture-MS Homo sapiens
92 XRCC5 7520
Affinity Capture-MS Homo sapiens
93 HUWE1 10075
Affinity Capture-MS Homo sapiens
94 PRSS22 64063
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 EHBP1L1 254102
Co-fractionation Homo sapiens
96 ARHGEF18 23370
Co-fractionation Homo sapiens
97 ARRB2 409
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
98 FBXW11  
Affinity Capture-MS Homo sapiens
99 FOXO3  
Co-fractionation Homo sapiens
100 INPPL1 3636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 TRIM52  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
102 MCM5 4174
Co-fractionation Homo sapiens
103 NT5C2 22978
Affinity Capture-MS Homo sapiens
104 FBXL14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 VWA9  
Affinity Capture-MS Homo sapiens
106 SMURF1 57154
Affinity Capture-MS Homo sapiens
107 INSR 3643
Affinity Capture-Western Homo sapiens
108 PDDC1 347862
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 RASL11B  
Affinity Capture-MS Homo sapiens
110 TOR1AIP1 26092
Affinity Capture-MS Homo sapiens
111 ROR2 4920
Two-hybrid Homo sapiens
112 CER1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 COQ2  
Affinity Capture-MS Homo sapiens
114 ADAMTS12 81792
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 NEDD1 121441
Affinity Capture-MS Homo sapiens
116 MAPK9 5601
Co-fractionation Homo sapiens
117 PRKCA 5578
Biochemical Activity Homo sapiens
118 UBE3D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 TMEM31  
Affinity Capture-MS Homo sapiens
120 FANCI 55215
Affinity Capture-MS Homo sapiens
121 TIMP3 7078
Affinity Capture-MS Homo sapiens
122 SLC25A5 292
Affinity Capture-MS Homo sapiens
123 Tecpr2  
Affinity Capture-MS Mus musculus
124 ASB2  
Affinity Capture-MS Homo sapiens
125 TRIM47 91107
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here