Gene description for PAK1
Gene name p21 protein (Cdc42/Rac)-activated kinase 1
Gene symbol PAK1
Other names/aliases PAKalpha
Species Homo sapiens
 Database cross references - PAK1
ExoCarta ExoCarta_5058
Vesiclepedia VP_5058
Entrez Gene 5058
HGNC 8590
MIM 602590
UniProt Q13153  
 PAK1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PAK1
Molecular Function
    protein kinase activity GO:0004672 IDA
    protein serine/threonine kinase activity GO:0004674 EXP
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 TAS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein binding GO:0005515 IPI
    collagen binding GO:0005518 IPI
    ATP binding GO:0005524 IEA
    small GTPase binding GO:0031267 IPI
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    identical protein binding GO:0042802 IPI
    gamma-tubulin binding GO:0043015 IDA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    MAPK cascade GO:0000165 IDA
    positive regulation of protein phosphorylation GO:0001934 IMP
    stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS
    chromatin remodeling GO:0006338 IDA
    protein phosphorylation GO:0006468 IDA
    exocytosis GO:0006887 IEA
    apoptotic process GO:0006915 IEA
    DNA damage response GO:0006974 IDA
    positive regulation of cell population proliferation GO:0008284 IMP
    cellular response to starvation GO:0009267 IBA
    phosphorylation GO:0016310 IDA
    cell migration GO:0016477 IBA
    cell migration GO:0016477 IMP
    actin cytoskeleton organization GO:0030036 IDA
    actin cytoskeleton organization GO:0030036 IMP
    actin cytoskeleton organization GO:0030036 IMP
    positive regulation of cell migration GO:0030335 IDA
    positive regulation of microtubule polymerization GO:0031116 IMP
    regulation of actin cytoskeleton organization GO:0032956 IBA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA
    positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 IDA
    intracellular signal transduction GO:0035556 IBA
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    wound healing GO:0042060 IMP
    regulation of MAPK cascade GO:0043408 IBA
    positive regulation of JUN kinase activity GO:0043507 IMP
    protein autophosphorylation GO:0046777 IDA
    hepatocyte growth factor receptor signaling pathway GO:0048012 IMP
    ephrin receptor signaling pathway GO:0048013 TAS
    branching morphogenesis of an epithelial tube GO:0048754 IMP
    neuron projection morphogenesis GO:0048812 ISS
    regulation of axonogenesis GO:0050770 IBA
    positive regulation of stress fiber assembly GO:0051496 IMP
    negative regulation of cell proliferation involved in contact inhibition GO:0060244 IMP
    positive regulation of microtubule nucleation GO:0090063 IMP
    protein localization to cytoplasmic stress granule GO:1903608 IDA
Subcellular Localization
    ruffle GO:0001726 IDA
    nucleoplasm GO:0005654 IDA
    chromosome GO:0005694 IEA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    centrosome GO:0005813 IEA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    actin filament GO:0005884 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    cell-cell junction GO:0005911 IDA
    focal adhesion GO:0005925 IEA
    intercalated disc GO:0014704 ISS
    Z disc GO:0030018 ISS
    lamellipodium GO:0030027 IEA
    axon GO:0030424 ISS
    dendrite GO:0030425 ISS
    nuclear membrane GO:0031965 ISS
    ruffle membrane GO:0032587 IEA
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified PAK1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PAK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HDAC4  
Affinity Capture-MS Homo sapiens
2 ARHGEF2 9181
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
3 ZC3H7A  
Two-hybrid Homo sapiens
4 GIT2 9815
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
5 PAK2 5062
Affinity Capture-MS Homo sapiens
6 BRSK1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 SETX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CRIPAK  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
9 PPAT 5471
Co-fractionation Homo sapiens
10 SOX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 APP 351
Reconstituted Complex Homo sapiens
12 ARHGDIA 396
Affinity Capture-Western Homo sapiens
13 TGFBR1 7046
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
14 TAX1BP3 30851
Affinity Capture-MS Homo sapiens
15 YWHAZ 7534
Two-hybrid Homo sapiens
16 HSPA2 3306
Affinity Capture-MS Homo sapiens
17 SCRIB 23513
Affinity Capture-MS Homo sapiens
18 HGS 9146
Reconstituted Complex Homo sapiens
19 FBXO28  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 YWHAG 7532
Two-hybrid Homo sapiens
21 OR2K2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 PLCG1 5335
Reconstituted Complex Homo sapiens
23 ACVR2B  
Affinity Capture-MS Homo sapiens
24 ZBTB18  
Two-hybrid Homo sapiens
25 PAK1IP1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
26 DYNLL1 8655
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
27 PPM1A 5494
Biochemical Activity Homo sapiens
28 CHORDC1 26973
Two-hybrid Homo sapiens
29 POU3F1  
Affinity Capture-MS Homo sapiens
30 LIMK1 3984
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
31 PAQR3  
Affinity Capture-MS Homo sapiens
32 MAPK14 1432
Affinity Capture-Western Homo sapiens
33 SNX27 81609
Affinity Capture-MS Homo sapiens
34 ZNF418  
Two-hybrid Homo sapiens
35 MAPK4  
Affinity Capture-MS Homo sapiens
36 NCK1 4690
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
37 DYRK1B  
Two-hybrid Homo sapiens
38 TPT1 7178
Co-fractionation Homo sapiens
39 PAK1 5058
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
40 PAK3  
Affinity Capture-MS Homo sapiens
41 PPP1CA 5499
Biochemical Activity Homo sapiens
42 HIST1H4A 8359
Biochemical Activity Homo sapiens
43 TGM2 7052
Two-hybrid Homo sapiens
44 CDK5 1020
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
45 ZNF83  
Two-hybrid Homo sapiens
46 MYNN 55892
Two-hybrid Homo sapiens
47 GIT1 28964
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
48 C5orf42  
Two-hybrid Homo sapiens
49 PPP2CA 5515
Biochemical Activity Homo sapiens
50 ARHGEF6 9459
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 DYNLL2 140735
Two-hybrid Homo sapiens
52 BMX  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
53 RHOJ 57381
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 NANOS1 340719
Affinity Capture-MS Homo sapiens
55 RYBP  
Affinity Capture-MS Homo sapiens
56 PARP3 10039
Affinity Capture-MS Homo sapiens
57 ABI3 51225
Reconstituted Complex Homo sapiens
58 PKLR 5313
Affinity Capture-Western Homo sapiens
59 RHOU 58480
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
60 ICAM1 3383
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 ARPC1B 10095
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
62 ILKAP 80895
Co-fractionation Homo sapiens
63 RELA 5970
Affinity Capture-Western Homo sapiens
64 SLC9A3R2 9351
Affinity Capture-MS Homo sapiens
65 EGFR 1956
Two-hybrid Homo sapiens
PCA Homo sapiens
66 MAP3K1 4214
Biochemical Activity Homo sapiens
67 SLC25A41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 CDC42 998
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
69 ZNF823  
Two-hybrid Homo sapiens
70 MYO6 4646
Biochemical Activity Homo sapiens
71 ERBB2 2064
Affinity Capture-Western Homo sapiens
72 RAF1 5894
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
73 WDR26 80232
Affinity Capture-Western Homo sapiens
74 AKT1 207
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
75 BAIAP2 10458
Reconstituted Complex Homo sapiens
76 H2AFX 3014
Affinity Capture-MS Homo sapiens
77 ARHGEF7 8874
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
78 BAD  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
79 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
80 MYLK 4638
Biochemical Activity Homo sapiens
81 TGFBR2 7048
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
82 TAS2R41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 PYCARD 29108
Affinity Capture-Western Homo sapiens
84 FGB 2244
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 FSD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 HSP90AA1 3320
Two-hybrid Homo sapiens
87 GNB1 2782
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
88 LPXN 9404
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 NCK2 8440
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
90 ESR1  
Affinity Capture-Western Homo sapiens
91 ELF3 1999
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
92 PXN 5829
Co-fractionation Homo sapiens
93 SNW1 22938
Affinity Capture-MS Homo sapiens
94 SH3KBP1 30011
Affinity Capture-Western Homo sapiens
95 RAC1 5879
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
96 CDK11A 728642
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PAK1 is involved
PathwayEvidenceSource
Activation of RAC1 IEA Reactome
Adaptive Immune System TAS Reactome
Axon guidance TAS Reactome
Axon guidance IEA Reactome
C-type lectin receptors (CLRs) TAS Reactome
CD209 (DC-SIGN) signaling TAS Reactome
CD28 co-stimulation TAS Reactome
CD28 dependent Vav1 pathway TAS Reactome
CDC42 GTPase cycle TAS Reactome
Costimulation by the CD28 family TAS Reactome
Developmental Biology TAS Reactome
Developmental Biology IEA Reactome
EPH-Ephrin signaling TAS Reactome
EPHB-mediated forward signaling TAS Reactome
Ephrin signaling TAS Reactome
Fc epsilon receptor (FCERI) signaling IEA Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
FCERI mediated MAPK activation IEA Reactome
FCERI mediated MAPK activation TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis TAS Reactome
G beta:gamma signalling through CDC42 TAS Reactome
G-protein beta:gamma signalling TAS Reactome
Generation of second messenger molecules TAS Reactome
GPCR downstream signalling TAS Reactome
Immune System IEA Reactome
Immune System TAS Reactome
Innate Immune System IEA Reactome
Innate Immune System TAS Reactome
L1CAM interactions TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK6/MAPK4 signaling TAS Reactome
Muscle contraction TAS Reactome
Nervous system development TAS Reactome
Nervous system development IEA Reactome
RAC1 GTPase cycle TAS Reactome
RAC2 GTPase cycle TAS Reactome
RAC3 GTPase cycle TAS Reactome
Regulation of actin dynamics for phagocytic cup formation TAS Reactome
RHO GTPase cycle TAS Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases activate PAKs TAS Reactome
RHO GTPases activate PAKs IEA Reactome
RHO GTPases activate PKNs IEA Reactome
RHO GTPases Activate ROCKs IEA Reactome
RHOH GTPase cycle TAS Reactome
RHOJ GTPase cycle TAS Reactome
RHOQ GTPase cycle TAS Reactome
RHOU GTPase cycle TAS Reactome
RHOV GTPase cycle TAS Reactome
Sema3A PAK dependent Axon repulsion TAS Reactome
Semaphorin interactions TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signal transduction by L1 TAS Reactome
Signaling by GPCR TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Signaling by ROBO receptors IEA Reactome
Signaling by VEGF TAS Reactome
Smooth Muscle Contraction TAS Reactome
TCR signaling TAS Reactome
VEGFA-VEGFR2 Pathway TAS Reactome
VEGFR2 mediated vascular permeability TAS Reactome





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