Gene description for TAX1BP3
Gene name Tax1 (human T-cell leukemia virus type I) binding protein 3
Gene symbol TAX1BP3
Other names/aliases TIP-1
Species Homo sapiens
 Database cross references - TAX1BP3
ExoCarta ExoCarta_30851
Entrez Gene 30851
HGNC 30684
UniProt O14907  
 TAX1BP3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Urine 19056867    
 Gene ontology annotations for TAX1BP3
Molecular Function
    protein binding GO:0005515 IPI
    protein C-terminus binding GO:0008022 IPI
    beta-catenin binding GO:0008013 IEA
Biological Process
    small GTPase mediated signal transduction GO:0007264 TAS
    negative regulation of Wnt signaling pathway GO:0030178 ISS
    Rho protein signal transduction GO:0007266 IDA
    negative regulation of cell proliferation GO:0008285 IEA
    negative regulation of protein localization to cell surface GO:2000009 IDA
    Wnt signaling pathway GO:0016055 IEA
    activation of GTPase activity GO:0090630 IDA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    actin cytoskeleton GO:0015629 IDA
    cytosol GO:0005829 TAS
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 NAS
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified TAX1BP3 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
3
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for TAX1BP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ctnnb1  
Reconstituted Complex Mus musculus
2 TCEA2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TAX1BP3 is involved
PathwayEvidenceSource
RHO GTPases Activate Rhotekin and Rhophilins TAS Reactome





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