Gene description for CDH3
Gene name cadherin 3, type 1, P-cadherin (placental)
Gene symbol CDH3
Other names/aliases CDHP
HJMD
PCAD
Species Homo sapiens
 Database cross references - CDH3
ExoCarta ExoCarta_1001
Entrez Gene 1001
HGNC 1762
MIM 114021
UniProt P22223  
 CDH3 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
 Gene ontology annotations for CDH3
Molecular Function
    molecular_function GO:0003674 ND
    calcium ion binding GO:0005509 IEA
Biological Process
    positive regulation of melanin biosynthetic process GO:0048023 IMP
    negative regulation of catagen GO:0051796 IMP
    single organismal cell-cell adhesion GO:0016337 IEA
    visual perception GO:0007601 IEA
    hair cycle process GO:0022405 IMP
    positive regulation of gene expression GO:0010628 IMP
    wound healing GO:0042060 IEA
    cell junction assembly GO:0034329 TAS
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    positive regulation of monophenol monooxygenase activity GO:0032773 IMP
    adherens junction organization GO:0034332 TAS
    cell-cell junction organization GO:0045216 TAS
    response to drug GO:0042493 IEA
    negative regulation of transforming growth factor beta2 production GO:0032912 IMP
    positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 IMP
    positive regulation of keratinocyte proliferation GO:0010838 IMP
    retina homeostasis GO:0001895 IMP
    cell adhesion GO:0007155 TAS
    canonical Wnt signaling pathway GO:0060070 IMP
    keratinization GO:0031424 IMP
    positive regulation of melanosome transport GO:1902910 IMP
    regulation of hair cycle by canonical Wnt signaling pathway GO:0060901 IMP
Subcellular Localization
    plasma membrane GO:0005886 TAS
    cytoplasm GO:0005737 IEA
    cell-cell adherens junction GO:0005913 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified CDH3 in exosomes
1
Experiment ID 207
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
✘ EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
5
Experiment ID 274
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for CDH3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDH3 1001
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
2 CTNNB1 1499
Invivo Homo sapiens
Invivo Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
3 CD2AP 23607
Affinity Capture-Western Homo sapiens
4 CTNNA1 1495
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
5 CDH1 999
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
6 JUP 3728
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
7 NPHS1 4868
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
8 CASP8  
Invivo Homo sapiens
Invitro Homo sapiens
9 CTNND1 1500
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CDH3 is involved
PathwayEvidenceSource
Adherens junctions interactions TAS Reactome





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