Gene description for CYTH2
Gene name cytohesin 2
Gene symbol CYTH2
Other names/aliases ARNO
CTS18
CTS18.1
PSCD2
PSCD2L
SEC7L
Sec7p-L
Sec7p-like
Species Homo sapiens
 Database cross references - CYTH2
ExoCarta ExoCarta_9266
Entrez Gene 9266
HGNC 9502
MIM 602488
UniProt Q99418  
 CYTH2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for CYTH2
Molecular Function
    lipid binding GO:0008289 IEA
    protein binding GO:0005515 IPI
    inositol 1,4,5 trisphosphate binding GO:0070679 ISS
    ARF guanyl-nucleotide exchange factor activity GO:0005086 ISS
Biological Process
    endocytosis GO:0006897 TAS
    positive regulation of GTPase activity GO:0043547 TAS
    actin cytoskeleton organization GO:0030036 TAS
    regulation of cell adhesion GO:0030155 IBA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 TAS
    trans-Golgi network GO:0005802 IBA
 Experiment description of studies that identified CYTH2 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CYTH2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IPCEF1 26034
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 SFN 2810
Affinity Capture-MS Homo sapiens
3 JM11  
Two-hybrid Homo sapiens
4 ARF3  
Biochemical Activity 4932
5 TRIM23 373
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
6 ARRB1 408
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 ARF6 382
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
8 ARRB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
9 ARF1 375
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which CYTH2 is involved
No pathways found





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