Gene description for IPCEF1
Gene name interaction protein for cytohesin exchange factors 1
Gene symbol IPCEF1
Other names/aliases PIP3-E
Species Homo sapiens
 Database cross references - IPCEF1
ExoCarta ExoCarta_26034
Entrez Gene 26034
HGNC 21204
UniProt Q8WWN9  
 IPCEF1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for IPCEF1
Molecular Function
    peroxidase activity GO:0004601 ISS
    oxygen transporter activity GO:0005344 NAS
Biological Process
    oxygen transport GO:0015671 NAS
    response to oxidative stress GO:0006979 ISS
    oxidation-reduction process GO:0055114 ISS
Subcellular Localization
    plasma membrane GO:0005886 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified IPCEF1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for IPCEF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CYTH3 9265
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
2 PSCD4  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
3 CYTH2 9266
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
4 PSCD1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which IPCEF1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here