Gene description for CYTH1
Gene name cytohesin 1
Gene symbol CYTH1
Other names/aliases B2-1
CYTOHESIN-1
D17S811E
PSCD1
SEC7
Species Homo sapiens
 Database cross references - CYTH1
ExoCarta ExoCarta_9267
Vesiclepedia VP_9267
Entrez Gene 9267
HGNC 9501
MIM 182115
UniProt Q15438  
 CYTH1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CYTH1
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IDA
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IEA
Biological Process
    vesicle-mediated transport GO:0016192 TAS
    regulation of cell adhesion GO:0030155 IDA
    regulation of ARF protein signal transduction GO:0032012 IEA
    establishment of epithelial cell polarity GO:0090162 ISS
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 ISS
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    adherens junction GO:0005912 IEA
    bicellular tight junction GO:0005923 ISS
    cytoplasmic side of plasma membrane GO:0009898 ISS
 Experiment description of studies that identified CYTH1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CYTH1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 FRMD4A  
Affinity Capture-MS Homo sapiens
3 MECP2 4204
Affinity Capture-MS Homo sapiens
4 ARRB2 409
Affinity Capture-Western Homo sapiens
5 CNKSR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
6 Zbtb7a  
Affinity Capture-MS Mus musculus
7 ITSN1 6453
Two-hybrid Homo sapiens
8 BACH1 571
Affinity Capture-MS Homo sapiens
9 KIF14 9928
Affinity Capture-MS Homo sapiens
10 UBA5 79876
Affinity Capture-MS Homo sapiens
11 SYCE1  
Affinity Capture-MS Homo sapiens
12 POTEI 653269
Affinity Capture-MS Homo sapiens
13 Dennd6a  
Affinity Capture-MS Mus musculus
14 C1orf106  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 GPS2  
Affinity Capture-MS Homo sapiens
16 CCDC120  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
17 UBA52 7311
Affinity Capture-MS Homo sapiens
18 JUN 3725
Affinity Capture-MS Homo sapiens
19 JUND 3727
Affinity Capture-MS Homo sapiens
20 GNAQ 2776
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
21 CALCOCO1 57658
Affinity Capture-MS Homo sapiens
22 CYTH2 9266
Affinity Capture-MS Homo sapiens
23 ARF6 382
Reconstituted Complex Homo sapiens
24 CYTH3 9265
Affinity Capture-MS Homo sapiens
25 SOX2  
Affinity Capture-MS Homo sapiens
26 IPCEF1 26034
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 PRPS2 5634
Affinity Capture-MS Homo sapiens
28 Nup214  
Affinity Capture-MS Mus musculus
29 APEX1 328
Affinity Capture-RNA Homo sapiens
30 ARFRP1 10139
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
31 KCNE3  
Affinity Capture-MS Homo sapiens
32 TAX1BP3 30851
Affinity Capture-MS Homo sapiens
33 TRIM23 373
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
34 ARRB1 408
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
35 SSSCA1 10534
Affinity Capture-MS Homo sapiens
36 OFD1 8481
Affinity Capture-MS Homo sapiens
37 PYCRL 65263
Affinity Capture-MS Homo sapiens
38 FRMD4B 23150
Affinity Capture-MS Homo sapiens
39 YWHAG 7532
Affinity Capture-MS Homo sapiens
40 SNAPC5  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
41 CCDC40  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ITGB2 3689
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
43 CYTIP  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
44 BACH2 60468
Affinity Capture-MS Homo sapiens
45 Mark2 13728
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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