Gene description for CYTH1
Gene name cytohesin 1
Gene symbol CYTH1
Other names/aliases B2-1
CYTOHESIN-1
D17S811E
PSCD1
SEC7
Species Homo sapiens
 Database cross references - CYTH1
ExoCarta ExoCarta_9267
Vesiclepedia VP_9267
Entrez Gene 9267
HGNC 9501
MIM 182115
UniProt Q15438  
 CYTH1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CYTH1
Molecular Function
    lipid binding GO:0008289 IEA
    protein binding GO:0005515 IPI
    ARF guanyl-nucleotide exchange factor activity GO:0005086 IDA
Biological Process
    regulation of cell adhesion GO:0030155 IDA
    establishment of epithelial cell polarity GO:0090162 IEA
    vesicle-mediated transport GO:0016192 TAS
    positive regulation of GTPase activity GO:0043547 TAS
Subcellular Localization
    bicellular tight junction GO:0005923 IEA
    cytoplasm GO:0005737 IDA
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 ISS
    cytosol GO:0005829 ISS
    plasma membrane GO:0005886 IDA
    trans-Golgi network GO:0005802 IBA
 Experiment description of studies that identified CYTH1 in exosomes
1
Experiment ID 488
MISEV standards
EM
EV Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
CANX
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CYTH1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSCDBP  
Invitro Homo sapiens
2 IPCEF1 26034
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
3 ARFRP1 10139
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
4 ITGB2 3689
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
5 TRIM23 373
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
6 ARF1 375
Invitro Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which CYTH1 is involved
No pathways found





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