Gene description for OFD1
Gene name oral-facial-digital syndrome 1
Gene symbol OFD1
Other names/aliases 71-7A
Species Homo sapiens
 Database cross references - OFD1
ExoCarta ExoCarta_8481
Entrez Gene 8481
HGNC 2567
MIM 300170
UniProt O75665  
 OFD1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for OFD1
Molecular Function
    alpha-tubulin binding GO:0043014 ISS
    gamma-tubulin binding GO:0043015 ISS
    protein binding GO:0005515 IPI
Biological Process
    G2/M transition of mitotic cell cycle GO:0000086 TAS
    axoneme assembly GO:0035082 IEA
    mitotic cell cycle GO:0000278 TAS
    embryonic body morphogenesis GO:0010172 IEA
    cilium morphogenesis GO:0060271 ISS
    mitotic spindle assembly GO:0090307 ISS
    mitotic nuclear division GO:0007067 ISS
    epithelial cilium movement involved in determination of left/right asymmetry GO:0060287 ISS
    organelle organization GO:0006996 TAS
    negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation GO:2000314 IEA
    centriole replication GO:0007099 ISS
Subcellular Localization
    cilium GO:0005929 IDA
    cytosol GO:0005829 TAS
    ciliary basal body GO:0036064 IDA
    centriole GO:0005814 IDA
    nucleus GO:0005634 IEA
    centriolar satellite GO:0034451 ISS
    microtubule cytoskeleton GO:0015630 IDA
    centrosome GO:0005813 IDA
    membrane GO:0016020 IDA
 Experiment description of studies that identified OFD1 in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for OFD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
Two-hybrid Homo sapiens
2 KIAA1377  
Two-hybrid Homo sapiens
3 LUC7L2  
Two-hybrid Homo sapiens
4 EIF6 3692
Two-hybrid Homo sapiens
5 KIAA1128  
Two-hybrid Homo sapiens
View the network image/svg+xml

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