Gene description for KRT38
Gene name keratin 38, type I
Gene symbol KRT38
Other names/aliases HA8
KRTHA8
hHa8
Species Homo sapiens
 Database cross references - KRT38
ExoCarta ExoCarta_8687
Vesiclepedia VP_8687
Entrez Gene 8687
HGNC 6456
MIM 604542
UniProt O76015  
 KRT38 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for KRT38
Molecular Function
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
Biological Process
    epithelial cell differentiation GO:0030855 IBA
    intermediate filament organization GO:0045109 IBA
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IBA
    intermediate filament GO:0005882 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified KRT38 in exosomes
1
Experiment ID 207
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
MISEV standards
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KRT38
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRT76 51350
Two-hybrid Homo sapiens
2 KRT4 3851
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 ATF7IP 55729
Affinity Capture-MS Homo sapiens
4 GNG10 2790
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 NUF2  
Affinity Capture-MS Homo sapiens
6 HOOK1  
Affinity Capture-MS Homo sapiens
7 ODF2L  
Affinity Capture-MS Homo sapiens
8 KRT6B 3854
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 KRT1 3848
Two-hybrid Homo sapiens
10 ATG5 9474
Affinity Capture-MS Homo sapiens
11 ALMS1  
Affinity Capture-MS Homo sapiens
12 KIFC3 3801
Two-hybrid Homo sapiens
13 KRT6A 3853
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
14 MCC 4163
Affinity Capture-MS Homo sapiens
15 APC  
Affinity Capture-MS Homo sapiens
16 EPS15 2060
Affinity Capture-MS Homo sapiens
17 TRIM33 51592
Affinity Capture-MS Homo sapiens
18 MAPKBP1  
Two-hybrid Homo sapiens
19 MYO5C 55930
Affinity Capture-MS Homo sapiens
20 TRIM62  
Affinity Capture-MS Homo sapiens
21 KIF7 374654
Affinity Capture-MS Homo sapiens
22 HDAC4  
Two-hybrid Homo sapiens
23 CEP97 79598
Affinity Capture-MS Homo sapiens
24 RNF40 9810
Affinity Capture-MS Homo sapiens
25 PCNT  
Affinity Capture-MS Homo sapiens
26 CNOT10 25904
Affinity Capture-MS Homo sapiens
27 CEP57L1  
Two-hybrid Homo sapiens
28 NAV1 89796
Affinity Capture-MS Homo sapiens
29 RAI14 26064
Affinity Capture-MS Homo sapiens
30 HGS 9146
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
31 ERC1 23085
Affinity Capture-MS Homo sapiens
32 ZYG11A  
Affinity Capture-MS Homo sapiens
33 KRT5 3852
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
34 HAUS6  
Affinity Capture-MS Homo sapiens
35 RAD51  
Affinity Capture-MS Homo sapiens
36 BEND3  
Affinity Capture-MS Homo sapiens
37 ZNF20  
Two-hybrid Homo sapiens
38 KIF2C 11004
Affinity Capture-MS Homo sapiens
39 HMG20B  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
40 KRT72 140807
Two-hybrid Homo sapiens
41 KRT83  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
42 VPS53 55275
Affinity Capture-MS Homo sapiens
43 ZWINT  
Affinity Capture-MS Homo sapiens
44 PKN3 29941
Affinity Capture-MS Homo sapiens
45 LMO4  
Two-hybrid Homo sapiens
46 EEA1 8411
Affinity Capture-MS Homo sapiens
47 C1orf216  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
48 APPBP2  
Affinity Capture-MS Homo sapiens
49 TXLNG  
Affinity Capture-MS Homo sapiens
50 SPAG5 10615
Affinity Capture-MS Homo sapiens
51 AMOTL2 51421
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
52 CENPH  
Affinity Capture-MS Homo sapiens
53 BEX2  
Two-hybrid Homo sapiens
54 TRIML2  
Two-hybrid Homo sapiens
55 CEP55 55165
Affinity Capture-MS Homo sapiens
56 PIBF1  
Affinity Capture-MS Homo sapiens
57 FAM110A  
Two-hybrid Homo sapiens
58 ZNF195  
Affinity Capture-MS Homo sapiens
59 KRBA1  
Affinity Capture-MS Homo sapiens
60 SCNM1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
61 EXOC4 60412
Affinity Capture-MS Homo sapiens
62 TRIM24  
Affinity Capture-MS Homo sapiens
63 OFD1 8481
Affinity Capture-MS Homo sapiens
64 ATG16L1 55054
Affinity Capture-MS Homo sapiens
65 BRCA2 675
Affinity Capture-MS Homo sapiens
66 CCDC120  
Two-hybrid Homo sapiens
67 KIF5A 3798
Affinity Capture-MS Homo sapiens
68 CEP152  
Affinity Capture-MS Homo sapiens
69 EXPH5  
Affinity Capture-MS Homo sapiens
70 KRT80 144501
Two-hybrid Homo sapiens
71 ERC2 26059
Affinity Capture-MS Homo sapiens
72 CCDC85C  
Affinity Capture-MS Homo sapiens
73 DTNB 1838
Two-hybrid Homo sapiens
74 KRT75 9119
Two-hybrid Homo sapiens
75 C17orf70  
Affinity Capture-MS Homo sapiens
76 CEP164  
Affinity Capture-MS Homo sapiens
77 TRIM32 22954
Affinity Capture-MS Homo sapiens
78 CCDC22 28952
Affinity Capture-MS Homo sapiens
79 KRT2 3849
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
80 VCPIP1 80124
Affinity Capture-MS Homo sapiens
81 TSC1 7248
Affinity Capture-MS Homo sapiens
82 ATF3  
Affinity Capture-MS Homo sapiens
83 KRT79 338785
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
84 ASPM 259266
Affinity Capture-MS Homo sapiens
85 TROAP  
Affinity Capture-MS Homo sapiens
86 KRT85  
Two-hybrid Homo sapiens
87 DISC1 27185
Affinity Capture-MS Homo sapiens
88 GAN 8139
Affinity Capture-MS Homo sapiens
89 ABI3 51225
Two-hybrid Homo sapiens
90 KRT3 3850
Two-hybrid Homo sapiens
91 C19orf57  
Two-hybrid Homo sapiens
92 CEP63  
Affinity Capture-MS Homo sapiens
93 KIF20A 10112
Affinity Capture-MS Homo sapiens
94 POTEI 653269
Affinity Capture-MS Homo sapiens
95 KRT86  
Two-hybrid Homo sapiens
96 CCDC186 55088
Affinity Capture-MS Homo sapiens
97 MAGEB4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
98 KLHL38  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
99 TXLNB  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
100 ZC4H2 55906
Affinity Capture-MS Homo sapiens
101 CSRP2BP  
Affinity Capture-MS Homo sapiens
102 CCP110  
Affinity Capture-MS Homo sapiens
103 CEBPG  
Affinity Capture-MS Homo sapiens
104 FAM90A1  
Two-hybrid Homo sapiens
105 MTFR1  
Affinity Capture-MS Homo sapiens
106 HOXA1 3198
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
107 TRAF3 7187
Affinity Capture-MS Homo sapiens
108 GNG13  
Two-hybrid Homo sapiens
109 CDK5RAP2 55755
Affinity Capture-MS Homo sapiens
110 HAUS5 23354
Affinity Capture-MS Homo sapiens
111 KRT81  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
112 NEFM 4741
Affinity Capture-MS Homo sapiens
113 SSNA1 8636
Affinity Capture-MS Homo sapiens
114 CCDC85B  
Affinity Capture-MS Homo sapiens
115 C14orf80  
Affinity Capture-MS Homo sapiens
116 ZFYVE21  
Two-hybrid Homo sapiens
117 PSMC5 5705
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
118 MYO9A 4649
Affinity Capture-MS Homo sapiens
119 ZNF587  
Two-hybrid Homo sapiens
120 RFWD3  
Affinity Capture-MS Homo sapiens
121 USHBP1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
122 TXNDC5 81567
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
123 PCM1 5108
Affinity Capture-MS Homo sapiens
124 LMNA 4000
Affinity Capture-MS Homo sapiens
125 PRR14L 253143
Affinity Capture-MS Homo sapiens
126 ZNF417  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
127 WAC  
Affinity Capture-MS Homo sapiens
128 HAUS4  
Affinity Capture-MS Homo sapiens
129 CD300A 11314
Two-hybrid Homo sapiens
130 ANKRD36BP1  
Two-hybrid Homo sapiens
131 HAUS1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
132 HSF4  
Two-hybrid Homo sapiens
133 TBC1D21 161514
Two-hybrid Homo sapiens
134 CCDC102A 92922
Affinity Capture-MS Homo sapiens
135 TXLNA 200081
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
136 CCDC146  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
137 PIN1 5300
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
138 IQGAP3 128239
Affinity Capture-MS Homo sapiens
139 CCHCR1  
Affinity Capture-MS Homo sapiens
140 RHPN1-AS1  
Two-hybrid Homo sapiens
141 TNFAIP8L2-SCNM1  
Two-hybrid Homo sapiens
142 SEPT10 151011
Affinity Capture-MS Homo sapiens
143 UTP23  
Two-hybrid Homo sapiens
144 FYCO1 79443
Affinity Capture-MS Homo sapiens
145 THAP11 57215
Affinity Capture-MS Homo sapiens
146 KRT71 112802
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
147 CREB1  
Affinity Capture-MS Homo sapiens
148 PTGER3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
149 CCDC93 54520
Affinity Capture-MS Homo sapiens
150 PSMA1 5682
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
151 VPS18 57617
Affinity Capture-MS Homo sapiens
152 KRT6C 286887
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
153 TRIM37  
Affinity Capture-MS Homo sapiens
154 KDM1A 23028
Two-hybrid Homo sapiens
155 KRT74 121391
Two-hybrid Homo sapiens
156 KRT8 3856
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
157 POU4F2  
Two-hybrid Homo sapiens
158 KXD1 79036
Affinity Capture-MS Homo sapiens
159 GLRX3 10539
Two-hybrid Homo sapiens
160 PIK3R2 5296
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
161 CCDC40  
Affinity Capture-MS Homo sapiens
162 ZNF318 24149
Affinity Capture-MS Homo sapiens
163 NIN 51199
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KRT38 is involved
PathwayEvidenceSource
Developmental Biology TAS Reactome
Formation of the cornified envelope TAS Reactome
Keratinization TAS Reactome





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