Gene description for HOXA1
Gene name homeobox A1
Gene symbol HOXA1
Other names/aliases BSAS
HOX1
HOX1F
Species Homo sapiens
 Database cross references - HOXA1
ExoCarta ExoCarta_3198
Vesiclepedia VP_3198
Entrez Gene 3198
HGNC 5099
MIM 142955
UniProt P49639  
 HOXA1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for HOXA1
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    sequence-specific DNA binding GO:0043565 IDA
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    sensory perception of sound GO:0007605 IDA
    optokinetic behavior GO:0007634 IDA
    anatomical structure morphogenesis GO:0009653 IMP
    abducens nerve formation GO:0021599 IMP
    outer ear morphogenesis GO:0042473 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    embryonic neurocranium morphogenesis GO:0048702 IMP
    inner ear development GO:0048839 IMP
    artery morphogenesis GO:0048844 IMP
    regulation of behavior GO:0050795 IDA
    cognition GO:0050890 IDA
    neuromuscular process GO:0050905 IDA
    artery development GO:0060840 IMP
    semicircular canal formation GO:0060876 IMP
    cochlea development GO:0090102 IMP
    cochlea morphogenesis GO:0090103 IMP
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
 Experiment description of studies that identified HOXA1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HOXA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GATA1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
2 BAHD1  
Two-hybrid Homo sapiens
3 KRT37 8688
Two-hybrid Homo sapiens
4 KRTAP12-3  
Two-hybrid Homo sapiens
5 PBX2  
Two-hybrid Homo sapiens
6 ZMAT1  
Two-hybrid Homo sapiens
7 INO80B 83444
Two-hybrid Homo sapiens
8 QARS 5859
Two-hybrid Homo sapiens
9 RBPMS 11030
Two-hybrid Homo sapiens
10 AGXT  
Two-hybrid Homo sapiens
11 LCE1B  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
12 KRTAP15-1  
Two-hybrid Homo sapiens
13 KRTAP2-3  
Two-hybrid Homo sapiens
14 RBP3  
Two-hybrid Homo sapiens
15 KRTAP9-8  
Two-hybrid Homo sapiens
16 AES 166
Two-hybrid Homo sapiens
17 MYO15B 80022
Two-hybrid Homo sapiens
18 ZNF703  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 KRTAP5-4  
Two-hybrid Homo sapiens
20 FHL3 2275
Two-hybrid Homo sapiens
21 MGAT5B  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 PLSCR4  
Two-hybrid Homo sapiens
23 BSCL2  
Two-hybrid Homo sapiens
24 IRX6  
Two-hybrid Homo sapiens
25 PRMT6  
Two-hybrid Homo sapiens
26 LMX1B  
Two-hybrid Homo sapiens
27 ENKD1  
Two-hybrid Homo sapiens
28 GAS8  
Two-hybrid Homo sapiens
29 OIT3 170392
Two-hybrid Homo sapiens
30 KRTAP5-9  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
31 TRIM55  
Two-hybrid Homo sapiens
32 GNE 10020
Two-hybrid Homo sapiens
33 STX11 8676
Two-hybrid Homo sapiens
34 SLPI 6590
Two-hybrid Homo sapiens
35 ARMC7  
Two-hybrid Homo sapiens
36 KRTAP2-4  
Two-hybrid Homo sapiens
37 HOXB9  
Two-hybrid Homo sapiens
38 KRTAP4-7  
Two-hybrid Homo sapiens
39 KRTAP4-12  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
40 LCE2A  
Two-hybrid Homo sapiens
41 SSC4D  
Two-hybrid Homo sapiens
42 ZNF843  
Two-hybrid Homo sapiens
43 LCE3C  
Two-hybrid Homo sapiens
44 TGFB1 7040
Two-hybrid Homo sapiens
45 WISP1 8840
Two-hybrid Homo sapiens
46 HR  
Two-hybrid Homo sapiens
47 WDR83  
Two-hybrid Homo sapiens
48 FAM221A  
Two-hybrid Homo sapiens
49 KRTAP10-10  
Two-hybrid Homo sapiens
50 INCA1  
Two-hybrid Homo sapiens
51 KRT40  
Two-hybrid Homo sapiens
52 COL8A1 1295
Two-hybrid Homo sapiens
53 SUV39H1  
Two-hybrid Homo sapiens
54 SNRPC 6631
Two-hybrid Homo sapiens
55 YIPF3 25844
Two-hybrid Homo sapiens
56 KRTAP4-2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
57 LGALS4 3960
Two-hybrid Homo sapiens
58 KRTAP10-11  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
59 KRT31 3881
Two-hybrid Homo sapiens
60 EFEMP1 2202
Two-hybrid Homo sapiens
61 RGS20 8601
Two-hybrid Homo sapiens
62 KRTAP4-11  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
63 KPRP 448834
Two-hybrid Homo sapiens
64 CATSPER1  
Two-hybrid Homo sapiens
65 KRTAP10-1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
66 IGFN1  
Two-hybrid Homo sapiens
67 ATG9B  
Two-hybrid Homo sapiens
68 ARID5A  
Two-hybrid Homo sapiens
69 PKNOX1  
Reconstituted Complex Homo sapiens
70 GUCD1  
Two-hybrid Homo sapiens
71 CREB5 9586
Two-hybrid Homo sapiens
72 SDCBP 6386
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
73 BUD31 8896
Two-hybrid Homo sapiens
74 PCYOX1 51449
Two-hybrid Homo sapiens
75 BATF2  
Two-hybrid Homo sapiens
76 KRTAP5-2  
Two-hybrid Homo sapiens
77 RALGDS  
Two-hybrid Homo sapiens
78 PRNP 5621
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
79 TRIM8  
Two-hybrid Homo sapiens
80 KRTAP4-1  
Two-hybrid Homo sapiens
81 FRS3 10817
Two-hybrid Homo sapiens
82 KRTAP5-6  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
83 ADAM12 8038
Two-hybrid Homo sapiens
84 ADAMTSL4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
85 LCE2C  
Two-hybrid Homo sapiens
86 NEDD9 4739
Two-hybrid Homo sapiens
87 LONRF1  
Two-hybrid Homo sapiens
88 RGS17  
Two-hybrid Homo sapiens
89 KRT34  
Two-hybrid Homo sapiens
90 SPRY3  
Two-hybrid Homo sapiens
91 FHL5 9457
Two-hybrid Homo sapiens
92 TEKT5  
Two-hybrid Homo sapiens
93 AMMECR1  
Two-hybrid Homo sapiens
94 ZIM2  
Two-hybrid Homo sapiens
95 PLSCR1 5359
Two-hybrid Homo sapiens
96 SPATA18  
Two-hybrid Homo sapiens
97 TRAPPC6A  
Two-hybrid Homo sapiens
98 HOXB1  
Affinity Capture-MS Homo sapiens
99 ZBTB16  
Two-hybrid Homo sapiens
100 NOV 4856
Two-hybrid Homo sapiens
101 KRTAP12-1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
102 CCDC33 80125
Two-hybrid Homo sapiens
103 TRIM42  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
104 GDF15 9518
Two-hybrid Homo sapiens
105 KRTAP19-7  
Two-hybrid Homo sapiens
106 HEY2  
Two-hybrid Homo sapiens
107 CFP  
Two-hybrid Homo sapiens
108 BAG4  
Two-hybrid Homo sapiens
109 CNNM3 26505
Two-hybrid Homo sapiens
110 CCDC120  
Two-hybrid Homo sapiens
111 LGALS13  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
112 KRTAP6-2  
Two-hybrid Homo sapiens
113 CD164 8763
Two-hybrid Homo sapiens
114 SPRY4 81848
Two-hybrid Homo sapiens
115 CYSRT1 375791
Two-hybrid Homo sapiens
116 KRTAP11-1  
Two-hybrid Homo sapiens
117 C11orf1  
Two-hybrid Homo sapiens
118 KDM5B  
Affinity Capture-MS Homo sapiens
119 ZNF837  
Two-hybrid Homo sapiens
120 PLEKHN1  
Two-hybrid Homo sapiens
121 LCE3E  
Two-hybrid Homo sapiens
122 TEKT4  
Two-hybrid Homo sapiens
123 KRTAP26-1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
124 SSUH2  
Two-hybrid Homo sapiens
125 PITX2  
Two-hybrid Homo sapiens
126 P2RY6  
Two-hybrid Homo sapiens
127 PIK3R1 5295
Two-hybrid Homo sapiens
128 SLC15A3  
Two-hybrid Homo sapiens
129 ID3  
Two-hybrid Homo sapiens
130 SIVA1  
Two-hybrid Homo sapiens
131 LCE1C  
Two-hybrid Homo sapiens
132 TRIM63  
Two-hybrid Homo sapiens
133 CERCAM 51148
Two-hybrid Homo sapiens
134 TGM7  
Two-hybrid Homo sapiens
135 GPS2  
Two-hybrid Homo sapiens
136 ZNF688  
Two-hybrid Homo sapiens
137 KRTAP10-7  
Two-hybrid Homo sapiens
138 DUSP22  
Two-hybrid Homo sapiens
139 NOTCH2NL 388677
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
140 FOXH1  
Two-hybrid Homo sapiens
141 LCE5A  
Two-hybrid Homo sapiens
142 KRT83  
Two-hybrid Homo sapiens
143 KRTAP1-5  
Two-hybrid Homo sapiens
144 KRTAP1-3  
Two-hybrid Homo sapiens
145 MDFI  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
146 DOK3 79930
Two-hybrid Homo sapiens
147 KRT33B 3884
Two-hybrid Homo sapiens
148 NXF1 10482
Two-hybrid Homo sapiens
149 KCTD9  
Two-hybrid Homo sapiens
150 CDPF1  
Two-hybrid Homo sapiens
151 KRT35 3886
Two-hybrid Homo sapiens
152 SNRPB 6628
Two-hybrid Homo sapiens
153 MYPOP  
Two-hybrid Homo sapiens
154 KRTAP10-8  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
155 ALG13 79868
Two-hybrid Homo sapiens
156 MAPKBP1  
Two-hybrid Homo sapiens
157 NFKBID  
Two-hybrid Homo sapiens
158 KRTAP9-3  
Two-hybrid Homo sapiens
159 IGFL1 374918
Two-hybrid Homo sapiens
160 XRCC6BP1  
Two-hybrid Homo sapiens
161 EGFL7 51162
Two-hybrid Homo sapiens
162 KRTAP10-3  
Two-hybrid Homo sapiens
163 HOXA1 3198
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
Two-hybrid Homo sapiens
164 VWC2  
Two-hybrid Homo sapiens
165 KRT82 3888
Two-hybrid Homo sapiens
166 PLLP  
Two-hybrid Homo sapiens
167 RSPO2  
Two-hybrid Homo sapiens
168 Hoxa1  
Two-hybrid Mus musculus
PCA Mus musculus
169 KRTAP10-4  
Two-hybrid Homo sapiens
170 KRTAP23-1  
Two-hybrid Homo sapiens
171 CNFN  
Two-hybrid Homo sapiens
172 KRTAP12-4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
173 KRTAP5-11  
Two-hybrid Homo sapiens
174 ESM1 11082
Two-hybrid Homo sapiens
175 TMEM57  
Two-hybrid Homo sapiens
176 NELL2  
Two-hybrid Homo sapiens
177 CHRD  
Two-hybrid Homo sapiens
178 LCE1A  
Two-hybrid Homo sapiens
179 SPRY1 10252
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
180 PROP1  
Two-hybrid Homo sapiens
181 KRTAP13-2  
Two-hybrid Homo sapiens
182 N4BP2L2 10443
Two-hybrid Homo sapiens
183 TNS2 23371
Two-hybrid Homo sapiens
184 LCE2D  
Two-hybrid Homo sapiens
185 ZNF587  
Two-hybrid Homo sapiens
186 KRTAP9-2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
187 PPP1R32  
Two-hybrid Homo sapiens
188 LCE4A  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
189 CXorf58  
Affinity Capture-MS Homo sapiens
190 KRTAP6-1  
Two-hybrid Homo sapiens
191 GCM2  
Two-hybrid Homo sapiens
192 AMOT  
Two-hybrid Homo sapiens
193 FAM219B 57184
Two-hybrid Homo sapiens
194 KRTAP3-2  
Two-hybrid Homo sapiens
195 DUSP10 11221
Two-hybrid Homo sapiens
196 ITGB4 3691
Two-hybrid Homo sapiens
197 ZNF417  
Two-hybrid Homo sapiens
198 KRTAP6-3  
Two-hybrid Homo sapiens
199 KRTAP10-5  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
200 UBL5 59286
Two-hybrid Homo sapiens
201 SLIT1 6585
Two-hybrid Homo sapiens
202 VWC2L  
Two-hybrid Homo sapiens
203 C17orf70  
Two-hybrid Homo sapiens
204 KRTAP3-3  
Two-hybrid Homo sapiens
205 TRIP6 7205
Two-hybrid Homo sapiens
206 KRTAP13-3  
Two-hybrid Homo sapiens
207 PVRL2 5819
Two-hybrid Homo sapiens
208 GRN 2896
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
209 TRAF2 7186
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Two-hybrid Homo sapiens
210 DOCK2 1794
Two-hybrid Homo sapiens
211 SPRY2 10253
Two-hybrid Homo sapiens
212 CUTA 51596
Two-hybrid Homo sapiens
213 GP9 2815
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
214 BHLHB9 80823
Two-hybrid Homo sapiens
215 NEK6 10783
Two-hybrid Homo sapiens
216 KRTAP4-4  
Two-hybrid Homo sapiens
217 WWOX 51741
Two-hybrid Homo sapiens
218 RGS19 10287
Two-hybrid Homo sapiens
219 PIN1 5300
Two-hybrid Homo sapiens
220 KRTAP19-6  
Two-hybrid Homo sapiens
221 BLZF1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
222 KRTAP9-4  
Two-hybrid Homo sapiens
223 NBPF19  
Two-hybrid Homo sapiens
224 TLE1 7088
Affinity Capture-MS Homo sapiens
225 MKRN3  
Two-hybrid Homo sapiens
226 KRTAP1-1  
Two-hybrid Homo sapiens
227 FAM109A