Gene description for INO80B
Gene name INO80 complex subunit B
Gene symbol INO80B
Other names/aliases HMGA1L4
HMGIYL4
IES2
PAP-1BP
PAPA-1
ZNHIT4
hIes2
Species Homo sapiens
 Database cross references - INO80B
ExoCarta ExoCarta_83444
Vesiclepedia VP_83444
Entrez Gene 83444
HGNC 13324
UniProt Q9C086  
 INO80B identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for INO80B
Molecular Function
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    telomere maintenance GO:0000723 ISO
    regulation of DNA replication GO:0006275 IMP
    DNA repair GO:0006281 IEA
    regulation of DNA repair GO:0006282 ISO
    DNA recombination GO:0006310 IEA
    chromatin remodeling GO:0006338 IDA
    regulation of chromosome organization GO:0033044 IMP
    positive regulation of DNA repair GO:0045739 ISO
    positive regulation of DNA-templated transcription GO:0045893 IMP
    regulation of embryonic development GO:0045995 ISO
    regulation of cell cycle GO:0051726 IMP
    regulation of DNA strand elongation GO:0060382 IMP
    positive regulation of telomere maintenance in response to DNA damage GO:1904507 ISO
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    nuclear body GO:0016604 IDA
    Ino80 complex GO:0031011 IBA
    Ino80 complex GO:0031011 IDA
 Experiment description of studies that identified INO80B in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for INO80B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNL2 29889
Affinity Capture-MS Homo sapiens
2 POLR2B 5431
Affinity Capture-MS Homo sapiens
3 MORN3  
Two-hybrid Homo sapiens
4 MCRS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 USH1G  
Two-hybrid Homo sapiens
6 Ruvbl1 56505
Affinity Capture-MS Mus musculus
7 KRTAP19-1  
Two-hybrid Homo sapiens
8 ZNF552  
Two-hybrid Homo sapiens
9 RPL30 6156
Affinity Capture-MS Homo sapiens
10 SRPK2 6733
Affinity Capture-MS Homo sapiens
11 NOTCH2NL 388677
Two-hybrid Homo sapiens
12 AES 166
Two-hybrid Homo sapiens
13 CARD9 64170
Two-hybrid Homo sapiens
14 DDX17 10521
Affinity Capture-MS Homo sapiens
15 LIMS1 3987
Two-hybrid Homo sapiens
16 BRD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 DVL3 1857
Two-hybrid Homo sapiens
18 RPS3 6188
Affinity Capture-MS Homo sapiens
19 KCTD7 154881
Two-hybrid Homo sapiens
20 DPPA4  
Two-hybrid Homo sapiens
21 ZNF526  
Two-hybrid Homo sapiens
22 RUVBL1 8607
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 FBXO3  
Affinity Capture-MS Homo sapiens
24 CEP70  
Two-hybrid Homo sapiens
25 KIF23 9493
Affinity Capture-MS Homo sapiens
26 PRPF38B 55119
Affinity Capture-MS Homo sapiens
27 RRP12 23223
Affinity Capture-MS Homo sapiens
28 RPL24 6152
Affinity Capture-MS Homo sapiens
29 KRT40  
Two-hybrid Homo sapiens
30 NPM1 4869
Affinity Capture-MS Homo sapiens
31 PIP4K2B 8396
Two-hybrid Homo sapiens
32 MTUS2 23281
Two-hybrid Homo sapiens
33 INO80E  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 BRD4 23476
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 UCHL5 51377
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 ZNF768 79724
Affinity Capture-MS Homo sapiens
37 RPS3A 6189
Affinity Capture-MS Homo sapiens
38 LHX4  
Two-hybrid Homo sapiens
39 MYCN  
Affinity Capture-MS Homo sapiens
40 WDR5 11091
Affinity Capture-MS Homo sapiens
41 CSNK2B 1460
Two-hybrid Homo sapiens
42 TNFRSF1B  
Affinity Capture-MS Homo sapiens
43 SREK1 140890
Affinity Capture-MS Homo sapiens
44 RPL19 6143
Affinity Capture-MS Homo sapiens
45 RBM14 10432
Affinity Capture-MS Homo sapiens
46 CHD1 1105
Affinity Capture-MS Homo sapiens
47 GOLGA6L9  
Two-hybrid Homo sapiens
48 RPL27 6155
Affinity Capture-MS Homo sapiens
49 KRT34  
Two-hybrid Homo sapiens
50 SCAF1  
Affinity Capture-MS Homo sapiens
51 DDX21 9188
Affinity Capture-MS Homo sapiens
52 NFRKB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 RPL4 6124
Affinity Capture-MS Homo sapiens
54 RIMBP3C  
Two-hybrid Homo sapiens
55 CDR2L  
Two-hybrid Homo sapiens
56 RPL18A 6142
Affinity Capture-MS Homo sapiens
57 KRTAP6-2  
Two-hybrid Homo sapiens
58 BCL7C  
Affinity Capture-MS Homo sapiens
59 DDX5 1655
Affinity Capture-MS Homo sapiens
60 RPL31 6160
Affinity Capture-MS Homo sapiens
61 ACTL6A 86
Affinity Capture-MS Homo sapiens
62 U2AF2 11338
Affinity Capture-MS Homo sapiens
63 PNMA2  
Two-hybrid Homo sapiens
64 LUC7L2 51631
Affinity Capture-MS Homo sapiens
65 RPL27A 6157
Affinity Capture-MS Homo sapiens
66 ACTB 60
Affinity Capture-MS Homo sapiens
67 PTRF 284119
Two-hybrid Homo sapiens
68 DHX9 1660
Affinity Capture-MS Homo sapiens
69 BOLL  
Two-hybrid Homo sapiens
70 RPLP0 6175
Affinity Capture-MS Homo sapiens
71 DICER1  
Affinity Capture-MS Homo sapiens
72 SRPK1 6732
Affinity Capture-MS Homo sapiens
73 SSX2IP  
Two-hybrid Homo sapiens
74 RPL11 6135
Affinity Capture-MS Homo sapiens
75 RSL1D1 26156
Affinity Capture-MS Homo sapiens
76 CYSRT1 375791
Two-hybrid Homo sapiens
77 SRSF11 9295
Affinity Capture-MS Homo sapiens
78 RBM39 9584
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
79 RPLP2 6181
Affinity Capture-MS Homo sapiens
80 INO80D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 RPS2 6187
Affinity Capture-MS Homo sapiens
82 CIAO1 9391
Affinity Capture-MS Homo sapiens
83 STAC3  
Two-hybrid Homo sapiens
84 TSPYL2  
Two-hybrid Homo sapiens
85 KRTAP10-8  
Two-hybrid Homo sapiens
86 RPL36A 6173
Affinity Capture-MS Homo sapiens
87 RPL21 6144
Affinity Capture-MS Homo sapiens
88 RPL3 6122
Affinity Capture-MS Homo sapiens
89 YY1 7528
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
90 TFPT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 DHX30 22907
Affinity Capture-MS Homo sapiens
92 HMBOX1  
Two-hybrid Homo sapiens
93 HOXA1 3198
Two-hybrid Homo sapiens
94 Ncaph  
Affinity Capture-MS Mus musculus
95 RPL7 6129
Affinity Capture-MS Homo sapiens
96 POLR2A 5430
Affinity Capture-MS Homo sapiens
97 THAP1  
Two-hybrid Homo sapiens
98 LZTS2 84445
Two-hybrid Homo sapiens
99 MAP7D1 55700
Affinity Capture-MS Homo sapiens
100 CD81 975
Two-hybrid Homo sapiens
101 ACTR5 79913
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 PRPF19 27339
Affinity Capture-MS Homo sapiens
103 INO80B 83444
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 CCDC85B  
Two-hybrid Homo sapiens
105 INO80  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 TRIM27  
Two-hybrid Homo sapiens
107 RPL12 6136
Affinity Capture-MS Homo sapiens
108 TNS2 23371
Two-hybrid Homo sapiens
109 ACTR8 93973
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 RPL18 6141
Affinity Capture-MS Homo sapiens
111 SBF1 6305
Affinity Capture-MS Homo sapiens
112 CACTIN  
Affinity Capture-MS Homo sapiens
113 TSR1 55720
Affinity Capture-MS Homo sapiens
114 BRD3 8019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 FTSJ3 117246
Affinity Capture-MS Homo sapiens
116 GNL3 26354
Affinity Capture-MS Homo sapiens
117 RPS16 6217
Affinity Capture-MS Homo sapiens
118 BANP  
Two-hybrid Homo sapiens
119 DDX46 9879
Affinity Capture-MS Homo sapiens
120 RPL13 6137
Affinity Capture-MS Homo sapiens
121 DHX15 1665
Affinity Capture-MS Homo sapiens
122 DDX50 79009
Affinity Capture-MS Homo sapiens
123 Ruvbl2 20174
Affinity Capture-MS Mus musculus
124 TRAF2 7186
Two-hybrid Homo sapiens
125 RPL6 6128
Affinity Capture-MS Homo sapiens
126 HOMEZ  
Two-hybrid Homo sapiens
127 PLAGL2  
Two-hybrid Homo sapiens
128 RUVBL2 10856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 BHLHB9 80823
Two-hybrid Homo sapiens
130 SCAF8 22828
Affinity Capture-MS Homo sapiens
131 NBPF19  
Two-hybrid Homo sapiens
132 SQSTM1 8878
Affinity Capture-MS Homo sapiens
133 MKRN3  
Two-hybrid Homo sapiens
134 PNMA1 9240
Two-hybrid Homo sapiens
135 PUF60 22827
Affinity Capture-MS Homo sapiens
136 CDC42BPA 8476
Affinity Capture-MS Homo sapiens
137 INO80C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 ABI2 10152
Two-hybrid Homo sapiens
139 ALYREF 10189
Affinity Capture-MS Homo sapiens
140 KRTAP12-2  
Two-hybrid Homo sapiens
141 YBX3 8531
Affinity Capture-MS Homo sapiens
142 RPL7A 6130
Affinity Capture-MS Homo sapiens
143 RPS8 6202
Affinity Capture-MS Homo sapiens
144 RPL8 6132
Affinity Capture-MS Homo sapiens
145 TRIB3  
Two-hybrid Homo sapiens
146 RPL28 6158
Affinity Capture-MS Homo sapiens
147 SERBP1 26135
Affinity Capture-MS Homo sapiens
148 SOX13  
Two-hybrid Homo sapiens
149 RPL23A 6147
Affinity Capture-MS Homo sapiens
150 KIF1C 10749
Affinity Capture-MS Homo sapiens
151 HSF2BP  
Two-hybrid Homo sapiens
152 ALS2CR12  
Two-hybrid Homo sapiens
153 LUC7L 55692
Affinity Capture-MS Homo sapiens
154 RPL17 6139
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here