Gene description for CHD1
Gene name chromodomain helicase DNA binding protein 1
Gene symbol CHD1
Other names/aliases -
Species Homo sapiens
 Database cross references - CHD1
ExoCarta ExoCarta_1105
Entrez Gene 1105
HGNC 1915
MIM 602118
UniProt O14646  
 CHD1 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for CHD1
Molecular Function
    ATP binding GO:0005524 IEA
    DNA binding GO:0003677 IEA
    ATP-dependent DNA helicase activity GO:0004003 TAS
    methylated histone binding GO:0035064 IDA
    protein binding GO:0005515 IPI
Biological Process
    DNA duplex unwinding GO:0032508 TAS
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    positive regulation by host of viral transcription GO:0043923 IMP
    transcription, DNA-templated GO:0006351 IEA
    chromatin remodeling GO:0006338 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified CHD1 in exosomes
Experiment ID 226
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for CHD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARRB1 408
Affinity Capture-MS Homo sapiens
2 NCOR1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
3 SSRP1 6749
Co-purification Homo sapiens
4 BCLAF1  
Two-hybrid Homo sapiens
5 HDAC1 3065
Affinity Capture-Western Homo sapiens
6 SAFB  
Two-hybrid Homo sapiens
7 SRSF3 6428
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CHD1 is involved
No pathways found

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