Gene description for RTF1
Gene name Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Gene symbol RTF1
Other names/aliases GTL7
KIAA0252
Species Homo sapiens
 Database cross references - RTF1
ExoCarta ExoCarta_23168
Vesiclepedia VP_23168
Entrez Gene 23168
HGNC 28996
MIM 611633
UniProt Q92541  
 RTF1 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for RTF1
Molecular Function
    single-stranded DNA binding GO:0003697 IDA
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    positive regulation of histone H3-K4 methylation GO:0051571 IEA
    Wnt signaling pathway GO:0016055 IEA
    DNA-templated transcription, initiation GO:0006352 IEA
    histone H3-K4 trimethylation GO:0080182 IEA
    stem cell maintenance GO:0019827 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS
    positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968 IDA
    endodermal cell fate commitment GO:0001711 ISS
Subcellular Localization
    Cdc73/Paf1 complex GO:0016593 IDA
    nucleolus GO:0005730 IEA
 Experiment description of studies that identified RTF1 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for RTF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARRB1 408
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RTF1 is involved
No pathways found





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