Gene description for CDK11B
Gene name cyclin-dependent kinase 11B
Gene symbol CDK11B
Other names/aliases CDC2L1
CDK11
CDK11-p110
CDK11-p46
CDK11-p58
CLK-1
PITSLREA
PK58
p58
p58CDC2L1
p58CLK-1
Species Homo sapiens
 Database cross references - CDK11B
ExoCarta ExoCarta_984
Vesiclepedia VP_984
Entrez Gene 984
HGNC 1729
MIM 176873
UniProt P21127  
 CDK11B identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for CDK11B
Molecular Function
    RNA binding GO:0003723 HDA
    protein kinase activity GO:0004672 TAS
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    cyclin-dependent protein serine/threonine kinase activity GO:0004693 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    protein serine kinase activity GO:0106310 IEA
Biological Process
    mitotic cell cycle GO:0000278 NAS
    regulation of cell growth GO:0001558 IEP
    regulation of DNA-templated transcription GO:0006355 NAS
    protein phosphorylation GO:0006468 IDA
    apoptotic process GO:0006915 NAS
    regulation of apoptotic process GO:0042981 NAS
    regulation of RNA splicing GO:0043484 ISS
    regulation of centrosome cycle GO:0046605 NAS
    regulation of mRNA processing GO:0050684 IDA
    regulation of cell cycle GO:0051726 IBA
    regulation of cell cycle GO:0051726 NAS
Subcellular Localization
    cyclin-dependent protein kinase holoenzyme complex GO:0000307 ISS
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified CDK11B in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CDK11B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNL2 29889
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 YWHAE 7531
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
4 ANAPC15  
Affinity Capture-MS Homo sapiens
5 NOP56 10528
Proximity Label-MS Homo sapiens
6 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
7 RSBN1  
Affinity Capture-MS Homo sapiens
8 ANKRD50 57182
Affinity Capture-MS Homo sapiens
9 KAT7  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
10 RNPS1 10921
Affinity Capture-MS Homo sapiens
11 CDK11B 984
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
12 RFXANK  
Affinity Capture-MS Homo sapiens
13 YWHAG 7532
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
14 MECP2 4204
Affinity Capture-MS Homo sapiens
15 VDR  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
16 NPAS1  
Affinity Capture-MS Homo sapiens
17 CSNK2B 1460
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 HSPA8 3312
Affinity Capture-MS Homo sapiens
19 YWHAB 7529
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
20 Bcas2  
Affinity Capture-MS Mus musculus
21 RPL27 6155
Co-fractionation Homo sapiens
22 FAM96A  
Affinity Capture-MS Homo sapiens
23 JMJD6 23210
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 TMEM14B  
Affinity Capture-MS Homo sapiens
25 RTF1 23168
Co-fractionation Homo sapiens
26 TGM2 7052
Affinity Capture-MS Homo sapiens
27 MEPCE 56257
Affinity Capture-MS Homo sapiens
28 PNKP 11284
Affinity Capture-MS Homo sapiens
29 SRSF6 6431
Affinity Capture-MS Homo sapiens
30 TPPP 11076
Two-hybrid Homo sapiens
31 NTRK1 4914
Affinity Capture-MS Homo sapiens
32 FGF8  
Affinity Capture-MS Homo sapiens
33 CCNL1  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
34 IFI16 3428
Affinity Capture-MS Homo sapiens
35 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
36 RAD18  
Affinity Capture-MS Homo sapiens
37 RAP1A 5906
Co-fractionation Homo sapiens
38 NSRP1  
Affinity Capture-MS Homo sapiens
39 YWHAQ 10971
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
40 ZRSR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 MAGEB2 4113
Affinity Capture-MS Homo sapiens
42 LRRTM4  
Affinity Capture-MS Homo sapiens
43 MRPS33  
Co-fractionation Homo sapiens
44 UBXN6 80700
Affinity Capture-MS Homo sapiens
45 CCNT1  
Affinity Capture-MS Homo sapiens
46 C1orf189  
Affinity Capture-MS Homo sapiens
47 BCLAF1 9774
Co-fractionation Homo sapiens
48 TPX2  
Affinity Capture-MS Homo sapiens
49 ZBTB2 57621
Affinity Capture-MS Homo sapiens
50 BTNL9  
Affinity Capture-MS Homo sapiens
51 PSENEN  
Affinity Capture-MS Homo sapiens
52 Kifc1  
Affinity Capture-MS Mus musculus
53 KMT2E  
Affinity Capture-MS Homo sapiens
54 SAP30BP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 YWHAZ 7534
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
56 RPS27A 6233
Two-hybrid Homo sapiens
57 METTL21B  
Affinity Capture-MS Homo sapiens
58 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
59 AP2M1 1173
Two-hybrid Homo sapiens
60 RANBP9 10048
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
61 FKBP5 2289
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 C12orf74  
Affinity Capture-MS Homo sapiens
63 MFAP1  
Affinity Capture-MS Homo sapiens
64 DNAI2  
Affinity Capture-MS Homo sapiens
65 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 HSPA4 3308
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
67 HIST1H1A 3024
Biochemical Activity Homo sapiens
68 DDRGK1 65992
Affinity Capture-MS Homo sapiens
69 MSN 4478
Two-hybrid Homo sapiens
70 MALL  
Affinity Capture-MS Homo sapiens
71 NKAP 79576
Co-fractionation Homo sapiens
72 MAPKAPK2 9261
Affinity Capture-MS Homo sapiens
73 EIF3F 8665
Biochemical Activity Homo sapiens
74 SIRT6  
Affinity Capture-MS Homo sapiens
75 PDE4B  
Protein-RNA Homo sapiens
76 ZRANB2 9406
Co-fractionation Homo sapiens
77 ZNF221  
Affinity Capture-MS Homo sapiens
78 RBM25 58517
Co-fractionation Homo sapiens
79 PIN1 5300
Reconstituted Complex Homo sapiens
80 EHHADH 1962
Affinity Capture-MS Homo sapiens
81 CDC37 11140
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
82 EPHX1 2052
Co-fractionation Homo sapiens
83 PNISR  
Co-fractionation Homo sapiens
84 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 EZH1  
Affinity Capture-MS Homo sapiens
86 POU2F1 5451
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
87 ESR1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
88 C20orf197  
Affinity Capture-MS Homo sapiens
89 HDGFRP2 84717
Co-fractionation Homo sapiens
90 IK 3550
Co-fractionation Homo sapiens
91 CCNT2  
Affinity Capture-MS Homo sapiens
92 CYCS 54205
Affinity Capture-MS Homo sapiens
93 PAF1 54623
Co-fractionation Homo sapiens
94 AP3D1 8943
Co-fractionation Homo sapiens
95 CCT8L2  
Affinity Capture-MS Homo sapiens
96 RPA3 6119
Proximity Label-MS Homo sapiens
97 UQCR11  
Affinity Capture-MS Homo sapiens
98 CDK11A 728642
Affinity Capture-MS Homo sapiens
99 CCND3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
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