Gene description for TPPP
Gene name tubulin polymerization promoting protein
Gene symbol TPPP
Other names/aliases TPPP/p25
TPPP1
p24
p25
p25alpha
Species Homo sapiens
 Database cross references - TPPP
ExoCarta ExoCarta_11076
Entrez Gene 11076
HGNC 24164
MIM 608773
UniProt O94811  
 TPPP identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for TPPP
Molecular Function
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 ISS
    tubulin binding GO:0015631 ISS
Biological Process
    microtubule polymerization GO:0046785 ISS
    positive regulation of protein polymerization GO:0032273 IDA
    microtubule bundle formation GO:0001578 ISS
    positive regulation of protein complex assembly GO:0031334 ISS
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 IDA
    cytoplasm GO:0005737 IDA
    microtubule GO:0005874 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified TPPP in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for TPPP
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TPPP is involved
No pathways found





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