Gene description for FADD
Gene name	Fas (TNFRSF6)-associated via death domain
Gene symbol	FADD
Other names/aliases	GIG3 MORT1
Species	Homo sapiens
Database cross references - FADD
ExoCarta	ExoCarta_8772
Entrez Gene	8772
HGNC	3573
MIM	602457
UniProt	Q13158
FADD identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for FADD

Molecular Function     protein binding GO:0005515 IPI     tumor necrosis factor receptor binding GO:0005164 IEA     identical protein binding GO:0042802 IPI     tumor necrosis factor receptor superfamily binding GO:0032813 IPI     protein complex binding GO:0032403 IEA     protease binding GO:0002020 IPI     death effector domain binding GO:0035877 IPI     death receptor binding GO:0005123 IEA Biological Process     cell surface receptor signaling pathway GO:0007166 TAS     positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 IEA     negative regulation of necroptotic process GO:0060546 IEA     regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 TAS     positive regulation of proteolysis GO:0045862 IDA     T cell homeostasis GO:0043029 ISS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     positive regulation of tumor necrosis factor production GO:0032760 IDA     cellular response to mechanical stimulus GO:0071260 IEP     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 TAS     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     apoptotic process GO:0006915 TAS     positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEP     programmed necrotic cell death GO:0097300 TAS     activation of cysteine-type endopeptidase activity GO:0097202 IDA     toll-like receptor 3 signaling pathway GO:0034138 TAS     protein heterooligomerization GO:0051291 IEA     necroptotic signaling pathway GO:0097527 IMP     thymus development GO:0048538 ISS     lymph node development GO:0048535 ISS     apoptotic signaling pathway GO:0097190 TAS     viral process GO:0016032 IEA     spleen development GO:0048536 ISS     defense response to virus GO:0051607 IMP     positive regulation of T cell mediated cytotoxicity GO:0001916 ISS     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     positive regulation of type I interferon-mediated signaling pathway GO:0060340 IMP     death-inducing signaling complex assembly GO:0071550 TAS     extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 IEA     necroptotic process GO:0070266 TAS     negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 TAS     programmed cell death GO:0012501 TAS     activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 TAS     tumor necrosis factor-mediated signaling pathway GO:0033209 TAS     positive regulation of interleukin-8 production GO:0032757 IDA     toll-like receptor signaling pathway GO:0002224 TAS     positive regulation of adaptive immune response GO:0002821 ISS     activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 TAS     extrinsic apoptotic signaling pathway GO:0097191 TAS     TRAIL-activated apoptotic signaling pathway GO:0036462 IDA     positive regulation of activated T cell proliferation GO:0042104 ISS     positive regulation of macrophage differentiation GO:0045651 IMP     innate immune response GO:0045087 TAS     positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IMP     regulation of necrotic cell death GO:0010939 TAS     negative regulation of activation-induced cell death of T cells GO:0070236 ISS     T cell differentiation in thymus GO:0033077 ISS     positive regulation of interferon-gamma production GO:0032729 ISS     positive regulation of apoptotic process GO:0043065 IMP     toll-like receptor 4 signaling pathway GO:0034142 TAS     motor neuron apoptotic process GO:0097049 IEA     positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation GO:2000454 ISS Subcellular Localization     cytosol GO:0005829 TAS     membrane raft GO:0045121 IEA     neuron projection GO:0043005 IEA     death-inducing signaling complex GO:0031264 TAS     ripoptosome GO:0097342 IDA     cell body GO:0044297 IEA     CD95 death-inducing signaling complex GO:0031265 IDA