Gene description for MOB4
Gene name MOB family member 4, phocein
Gene symbol MOB4
Other names/aliases 2C4D
CGI-95
MOB1
MOB3
MOBKL3
PHOCN
PREI3
Species Homo sapiens
 Database cross references - MOB4
ExoCarta ExoCarta_25843
Vesiclepedia VP_25843
Entrez Gene 25843
HGNC 17261
MIM 609361
UniProt Q9Y3A3  
 MOB4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MOB4
Molecular Function
    protein binding GO:0005515 IPI
    protein-macromolecule adaptor activity GO:0030674 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of hippo signaling GO:0035331 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
    Golgi apparatus GO:0005794 IDA
    Golgi cisterna membrane GO:0032580 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    FAR/SIN/STRIPAK complex GO:0090443 IDA
 Experiment description of studies that identified MOB4 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MOB4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAF3IP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 STK25 10494
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CCT3 7203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SNX24  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 PAXIP1  
Affinity Capture-MS Homo sapiens
6 CCT5 22948
Affinity Capture-MS Homo sapiens
7 SIKE1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 Strip1  
Affinity Capture-MS Mus musculus
9 RABEP2 79874
Affinity Capture-MS Homo sapiens
10 RIT1 6016
Negative Genetic Homo sapiens
11 S100A6 6277
Affinity Capture-MS Homo sapiens
12 RPA2 6118
Proximity Label-MS Homo sapiens
13 PAICS 10606
Two-hybrid Homo sapiens
14 STRN3 29966
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
15 AGA 175
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 VHL  
Affinity Capture-MS Homo sapiens
17 PLEKHM1  
Two-hybrid Homo sapiens
18 SETDB1  
Two-hybrid Homo sapiens
19 CAB39 51719
Affinity Capture-MS Homo sapiens
20 PDCD10 11235
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 PPP2R1B 5519
Affinity Capture-MS Homo sapiens
22 STRN 6801
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
23 MCM2 4171
Two-hybrid Homo sapiens
24 SF3B1 23451
Co-fractionation Homo sapiens
25 DYNLL1 8655
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CRMP1 1400
Two-hybrid Homo sapiens
27 ATG16L1 55054
Affinity Capture-MS Homo sapiens
28 STRIP1 85369
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 LATS1  
Reconstituted Complex Homo sapiens
30 PKN3 29941
Affinity Capture-MS Homo sapiens
31 CTTNBP2NL  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 ARHGEF15  
Two-hybrid Homo sapiens
33 MYL6 4637
Two-hybrid Homo sapiens
34 CCT2 10576
Affinity Capture-MS Homo sapiens
35 UBR4 23352
Co-fractionation Homo sapiens
36 TCP1 6950
Affinity Capture-MS Homo sapiens
37 MCC 4163
Affinity Capture-MS Homo sapiens
38 RB1CC1 9821
Affinity Capture-MS Homo sapiens
39 GOLGA8G  
Affinity Capture-MS Homo sapiens
40 LRIF1  
Two-hybrid Homo sapiens
41 Arrb2  
Affinity Capture-MS Mus musculus
42 Ppp2ca 19052
Affinity Capture-MS Mus musculus
43 BARD1 580
Affinity Capture-MS Homo sapiens
44 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 DYNLL2 140735
Affinity Capture-MS Homo sapiens
46 MED31  
Two-hybrid Homo sapiens
47 DDX39B 7919
Co-fractionation Homo sapiens
48 PTPRS 5802
Two-hybrid Homo sapiens
49 GDF9 2661
Two-hybrid Homo sapiens
50 CTTNBP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 RMDN3 55177
Proximity Label-MS Homo sapiens
52 SNAP29 9342
Affinity Capture-MS Homo sapiens
53 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
54 CCDC59  
Affinity Capture-MS Homo sapiens
55 MINK1 50488
Affinity Capture-MS Homo sapiens
56 STK3 6788
Biochemical Activity Homo sapiens
Proximity Label-MS Homo sapiens
57 Strn3  
Affinity Capture-MS Mus musculus
58 PIP 5304
Affinity Capture-MS Homo sapiens
59 CCT6A 908
Affinity Capture-MS Homo sapiens
60 TNFRSF1A 7132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 EGFR 1956
PCA Homo sapiens
62 SPTBN1 6711
Co-fractionation Homo sapiens
63 MED10  
Two-hybrid Homo sapiens
64 RAPGEF2 9693
Two-hybrid Homo sapiens
65 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 CCDC85B  
Two-hybrid Homo sapiens
67 HSPA1A 3303
Affinity Capture-MS Homo sapiens
68 PSMC5 5705
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 Dynll1 56455
Affinity Capture-MS Mus musculus
70 KIAA0368 23392
Co-fractionation Homo sapiens
71 STK4 6789
Proximity Label-MS Homo sapiens
72 SCMH1  
Two-hybrid Homo sapiens
73 KIDINS220 57498
Two-hybrid Homo sapiens
74 PPP2CB 5516
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 ZRANB1 54764
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 RASSF3 283349
Affinity Capture-MS Homo sapiens
77 FADD 8772
Two-hybrid Homo sapiens
78 STK24 8428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 GIPC1 10755
Proximity Label-MS Homo sapiens
80 CCT8 10694
Affinity Capture-MS Homo sapiens
81 SLMAP 7871
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 PRDM14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 STRIP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 ISCA2 122961
Affinity Capture-MS Homo sapiens
85 SPINK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 LATS2 26524
Reconstituted Complex Homo sapiens
87 STK26 51765
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 FILIP1  
Affinity Capture-MS Homo sapiens
89 CCT7 10574
Affinity Capture-MS Homo sapiens
90 DDX39A 10212
Co-fractionation Homo sapiens
91 STRN4 29888
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
92 PSMA5 5686
Affinity Capture-MS Homo sapiens
93 FGFR1OP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 KRAS 3845
Negative Genetic Homo sapiens
95 UBE2V2 7336
Two-hybrid Homo sapiens
96 TIMM13 26517
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MOB4 is involved
No pathways found





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