Gene description for MOB4
Gene name MOB family member 4, phocein
Gene symbol MOB4
Other names/aliases 2C4D
CGI-95
MOB1
MOB3
MOBKL3
PHOCN
PREI3
Species Homo sapiens
 Database cross references - MOB4
ExoCarta ExoCarta_25843
Vesiclepedia VP_25843
Entrez Gene 25843
HGNC 17261
MIM 609361
UniProt Q9Y3A3  
 MOB4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MOB4
Molecular Function
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    kinase binding GO:0019900 IEA
Biological Process
    transport GO:0006810 IEA
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 IEA
    neuronal cell body GO:0043025 IEA
    cytoplasm GO:0005737 ISS
    dendritic spine GO:0043197 IEA
    cytosol GO:0005829 IEA
    Golgi apparatus GO:0005794 IDA
    Golgi cisterna membrane GO:0032580 IEA
 Experiment description of studies that identified MOB4 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MOB4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STRIP1 85369
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 PAICS 10606
Two-hybrid Homo sapiens
3 CCT7 10574
Affinity Capture-MS Homo sapiens
4 FADD 8772
Two-hybrid Homo sapiens
5 STK24 8428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 STK25 10494
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 MYL6 4637
Two-hybrid Homo sapiens
8 ARHGEF15  
Two-hybrid Homo sapiens
9 TRG20  
Two-hybrid Homo sapiens
10 FLJ21168  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CCT2 10576
Affinity Capture-MS Homo sapiens
12 RIF1  
Two-hybrid Homo sapiens
13 STRN4 29888
Affinity Capture-MS Homo sapiens
14 T3JAM  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
15 GDF9 2661
Two-hybrid Homo sapiens
16 TCP1 6950
Affinity Capture-MS Homo sapiens
17 STRN3 29966
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 CCT3 7203
Affinity Capture-MS Homo sapiens
19 VHL  
Affinity Capture-MS Homo sapiens
20 RB1CC1 9821
Affinity Capture-MS Homo sapiens
21 STK26 51765
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 PLEKHM1  
Two-hybrid Homo sapiens
23 FGFR1OP2  
Affinity Capture-MS Homo sapiens
24 SETDB1  
Two-hybrid Homo sapiens
25 CAB39 51719
Affinity Capture-MS Homo sapiens
26 CCT5 22948
Affinity Capture-MS Homo sapiens
27 PDCD10 11235
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 CCT6A 908
Affinity Capture-MS Homo sapiens
29 PPP2R1B 5519
Affinity Capture-MS Homo sapiens
30 DKFZp547A023  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
31 STRN 6801
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
32 PTPRS 5802
Two-hybrid Homo sapiens
33 CTTNBP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 MCM2 4171
Two-hybrid Homo sapiens
35 CCT8 10694
Affinity Capture-MS Homo sapiens
36 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 DIPA  
Two-hybrid Homo sapiens
38 HSPC128  
Affinity Capture-MS Homo sapiens
39 FAM40B  
Affinity Capture-MS Homo sapiens
40 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
41 SCMH1  
Two-hybrid Homo sapiens
42 KIDINS220 57498
Two-hybrid Homo sapiens
43 MED31  
Two-hybrid Homo sapiens
44 SLMAP 7871
Affinity Capture-MS Homo sapiens
45 UBE2V2 7336
Two-hybrid Homo sapiens
46 PPP2CB 5516
Affinity Capture-MS Homo sapiens
47 TIMM13 26517
Affinity Capture-MS Homo sapiens
48 CRMP1 1400
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MOB4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here