Gene description for PTPRS
Gene name protein tyrosine phosphatase, receptor type, S
Gene symbol PTPRS
Other names/aliases PTPSIGMA
Species Homo sapiens
 Database cross references - PTPRS
ExoCarta ExoCarta_5802
Vesiclepedia VP_5802
Entrez Gene 5802
HGNC 9681
MIM 601576
UniProt Q13332  
 PTPRS identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for PTPRS
Molecular Function
    phosphoprotein phosphatase activity GO:0004721 IDA
    protein tyrosine phosphatase activity GO:0004725 IBA
    protein tyrosine phosphatase activity GO:0004725 ISS
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 ISS
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    chondroitin sulfate binding GO:0035374 ISS
    heparan sulfate proteoglycan binding GO:0043395 ISS
    histone H2AXY142 phosphatase activity GO:0140793 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    protein dephosphorylation GO:0006470 IDA
    signal transduction GO:0007165 IBA
    negative regulation of neuron projection development GO:0010977 ISS
    spinal cord development GO:0021510 IEA
    cerebellum development GO:0021549 IEA
    hippocampus development GO:0021766 IEA
    cerebral cortex development GO:0021987 IEA
    corpus callosum development GO:0022038 IEA
    negative regulation of axon extension GO:0030517 ISS
    negative regulation of interferon-alpha production GO:0032687 IMP
    negative regulation of interferon-beta production GO:0032688 IMP
    negative regulation of toll-like receptor 9 signaling pathway GO:0034164 IMP
    peptidyl-tyrosine dephosphorylation GO:0035335 ISS
    negative regulation of collateral sprouting GO:0048671 ISS
    negative regulation of axon regeneration GO:0048681 ISS
    modulation of chemical synaptic transmission GO:0050804 IEA
    negative regulation of dendritic spine development GO:0061000 ISS
    establishment of endothelial intestinal barrier GO:0090557 IEA
    regulation of postsynaptic density assembly GO:0099151 IEA
    trans-synaptic signaling GO:0099537 IEA
    synaptic membrane adhesion GO:0099560 IBA
    synaptic membrane adhesion GO:0099560 IDA
    synaptic membrane adhesion GO:0099560 IMP
Subcellular Localization
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    axon GO:0030424 ISS
    growth cone GO:0030426 IEA
    synaptic vesicle membrane GO:0030672 ISS
    presynaptic membrane GO:0042734 IEA
    perikaryon GO:0043204 IEA
    extracellular exosome GO:0070062 HDA
    Schaffer collateral - CA1 synapse GO:0098685 IEA
    postsynaptic density membrane GO:0098839 ISS
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified PTPRS in exosomes
1
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
3
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PTPRS
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 PTPRF 5792
Proximity Label-MS Homo sapiens
3 RYK 6259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SGCA  
Affinity Capture-MS Homo sapiens
5 CSTL1  
Affinity Capture-MS Homo sapiens
6 LRRIQ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 CEACAM8 1088
Affinity Capture-MS Homo sapiens
8 CCL3  
Affinity Capture-MS Homo sapiens
9 EEF1G 1937
Two-hybrid Homo sapiens
10 NRSN1  
Affinity Capture-MS Homo sapiens
11 GPC2  
Reconstituted Complex Homo sapiens
12 IL20RB  
Affinity Capture-MS Homo sapiens
13 CSNK1G2 1455
Affinity Capture-MS Homo sapiens
14 PCDH12 51294
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 SEZ6L  
Affinity Capture-MS Homo sapiens
16 Gpc4 317322
Reconstituted Complex Rattus norvegicus
17 SETDB1  
Two-hybrid Homo sapiens
18 STX11 8676
Affinity Capture-MS Homo sapiens
19 PTPRB 5787
Affinity Capture-MS Homo sapiens
20 HEPACAM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 DLL1  
Affinity Capture-MS Homo sapiens
22 CTLA4  
Affinity Capture-MS Homo sapiens
23 MMP3 4314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 GINM1 116254
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SPANXN4  
Affinity Capture-MS Homo sapiens
26 CDH16  
Affinity Capture-MS Homo sapiens
27 GPRC5B 51704
Affinity Capture-MS Homo sapiens
28 ST14 6768
Affinity Capture-MS Homo sapiens
29 TMEM231 79583
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 GPC6 10082
Reconstituted Complex Homo sapiens
31 EDAR  
Affinity Capture-MS Homo sapiens
32 PFN2 5217
Two-hybrid Homo sapiens
33 IL13RA2 3598
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 CHD3 1107
Two-hybrid Homo sapiens
35 TMEM59 9528
Affinity Capture-MS Homo sapiens
36 PRPH2 5961
Affinity Capture-MS Homo sapiens
37 TNF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 PPFIA2 8499
Two-hybrid Homo sapiens
39 MANSC1 54682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 UTP14A 10813
Two-hybrid Homo sapiens
41 MOB4 25843
Two-hybrid Homo sapiens
42 CEACAM21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 CLU 1191
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 SMIM5  
Affinity Capture-MS Homo sapiens
45 MCAM 4162
Proximity Label-MS Homo sapiens
46 NTRK3 4916
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
47 C16orf58 64755
Affinity Capture-MS Homo sapiens
48 CGREF1 10669
Affinity Capture-MS Homo sapiens
49 NTRK1 4914
Affinity Capture-MS Homo sapiens
50 CRP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 ARRDC3 57561
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 UNC119 9094
Two-hybrid Homo sapiens
53 MRAP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 LIPG 9388
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 LRRTM4  
Affinity Capture-Western Homo sapiens
56 TMPRSS13  
Affinity Capture-MS Homo sapiens
57 SYT11 23208
Affinity Capture-MS Homo sapiens
58 EIF4A2 1974
Affinity Capture-MS Homo sapiens
59 PTN  
Two-hybrid Homo sapiens
60 PCDHGB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 GPC4 2239
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
62 IL31  
Affinity Capture-MS Homo sapiens
63 MARCH1  
Affinity Capture-MS Homo sapiens
64 ARRDC4  
Affinity Capture-MS Homo sapiens
65 TNFSF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 PTCH2  
Affinity Capture-MS Homo sapiens
67 ASPM 259266
Negative Genetic Homo sapiens
68 TRIO 7204
Proximity Label-MS Homo sapiens
69 FBXO6 26270
Affinity Capture-MS Homo sapiens
70 PDGFRB 5159
Affinity Capture-MS Homo sapiens
71 KCNE3  
Affinity Capture-MS Homo sapiens
72 UBR1 197131
Two-hybrid Homo sapiens
73 OPTC  
Affinity Capture-MS Homo sapiens
74 IFNAR1  
Affinity Capture-MS Homo sapiens
75 CRLF1 9244
Affinity Capture-MS Homo sapiens
76 FBXO2 26232
Affinity Capture-MS Homo sapiens
77 KLRG2 346689
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 SCGB2A2  
Affinity Capture-MS Homo sapiens
79 KAT5  
Two-hybrid Homo sapiens
80 EPO 2056
Affinity Capture-MS Homo sapiens
81 OMG  
Reconstituted Complex Homo sapiens
82 PPFIA1 8500
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
83 CASKIN2  
Proximity Label-MS Homo sapiens
84 TUBB2A 7280
Two-hybrid Homo sapiens
85 FEZ1  
Two-hybrid Homo sapiens
86 Sars 20226
Affinity Capture-MS Mus musculus
87 TGFBR2 7048
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 PTPRD 5789
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
89 FCGRT 2217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 TMEM30B 161291
Affinity Capture-MS Homo sapiens
91 FKBP9 11328
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 KIAA1377  
Two-hybrid Homo sapiens
93 HLA-DPA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 UGT1A7 54577
Affinity Capture-MS Homo sapiens
95 SLC39A5 283375
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 GPC3 2719
Reconstituted Complex Homo sapiens
97 PCDHGA7 56108
Affinity Capture-MS Homo sapiens
98 KCNE4  
Affinity Capture-MS Homo sapiens
99 DSG2 1829
Cross-Linking-MS (XL-MS) Homo sapiens
100 PPFIA3 8541
Two-hybrid Homo sapiens
View the network image/svg+xml



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