Gene description for CGREF1
Gene name cell growth regulator with EF-hand domain 1
Gene symbol CGREF1
Other names/aliases CGR11
Species Homo sapiens
 Database cross references - CGREF1
ExoCarta ExoCarta_10669
Vesiclepedia VP_10669
Entrez Gene 10669
HGNC 16962
MIM 606137
UniProt Q99674  
 CGREF1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CGREF1
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
Biological Process
    cell adhesion GO:0007155 IEA
    negative regulation of cell population proliferation GO:0008285 TAS
    regulation of cell cycle GO:0051726 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified CGREF1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CGREF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 HS3ST1  
Affinity Capture-MS Homo sapiens
3 TOR1A 1861
Affinity Capture-MS Homo sapiens
4 PDIA5 10954
Affinity Capture-MS Homo sapiens
5 IDUA 3425
Affinity Capture-MS Homo sapiens
6 TNKS 8658
Affinity Capture-MS Homo sapiens
7 METRN 79006
Affinity Capture-MS Homo sapiens
8 ACTA2 59
Affinity Capture-MS Homo sapiens
9 VGF  
Affinity Capture-MS Homo sapiens
10 MYO18A 399687
Affinity Capture-MS Homo sapiens
11 HSPA13 6782
Affinity Capture-MS Homo sapiens
12 LMAN1 3998
Affinity Capture-MS Homo sapiens
13 PPP1R9B 84687
Affinity Capture-MS Homo sapiens
14 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
15 TNKS2 80351
Affinity Capture-MS Homo sapiens
16 B4GALT4 8702
Affinity Capture-MS Homo sapiens
17 PTPRS 5802
Affinity Capture-MS Homo sapiens
18 GLB1L 79411
Affinity Capture-MS Homo sapiens
19 SEC22A  
Affinity Capture-MS Homo sapiens
20 OLFM2  
Affinity Capture-MS Homo sapiens
21 PEX5 5830
Affinity Capture-MS Homo sapiens
22 CTSF 8722
Affinity Capture-MS Homo sapiens
23 DAG1 1605
Affinity Capture-MS Homo sapiens
24 PLEKHG3 26030
Affinity Capture-MS Homo sapiens
25 BMP4 652
Affinity Capture-MS Homo sapiens
26 VWA1 64856
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CGREF1 is involved
No pathways found





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