Gene description for TNKS
Gene name	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Gene symbol	TNKS
Other names/aliases	ARTD5 PARP-5a PARP5A PARPL TIN1 TINF1 TNKS1 pART5
Species	Homo sapiens
Database cross references - TNKS
ExoCarta	ExoCarta_8658
Vesiclepedia	VP_8658
Entrez Gene	8658
HGNC	11941
MIM	603303
UniProt	O95271
TNKS identified in sEVs derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for TNKS

Molecular Function     NAD+-protein poly-ADP-ribosyltransferase activity GO:0003950 IBA     NAD+-protein poly-ADP-ribosyltransferase activity GO:0003950 IDA     NAD+-protein poly-ADP-ribosyltransferase activity GO:0003950 TAS     protein binding GO:0005515 IPI     zinc ion binding GO:0008270 IDA     nucleotidyltransferase activity GO:0016779 IEA     histone binding GO:0042393 IPI     NAD+-protein-aspartate ADP-ribosyltransferase activity GO:0140806 IEA     NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity GO:0140822 IEA     NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity GO:0140844 IEA     NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity GO:0140867 IEA     NAD+-protein ADP-ribosyltransferase activity GO:1990404 IDA Biological Process     protein polyubiquitination GO:0000209 IDA     mitotic spindle organization GO:0007052 TAS     protein transport GO:0015031 IEA     Wnt signaling pathway GO:0016055 IEA     peptidyl-serine phosphorylation GO:0018105 IDA     peptidyl-threonine phosphorylation GO:0018107 IDA     regulation of telomere maintenance via telomerase GO:0032210 TAS     positive regulation of telomere maintenance via telomerase GO:0032212 IDA     positive regulation of telomere maintenance via telomerase GO:0032212 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     mRNA transport GO:0051028 IEA     spindle assembly GO:0051225 TAS     cell division GO:0051301 IEA     protein localization to chromosome, telomeric region GO:0070198 IBA     protein localization to chromosome, telomeric region GO:0070198 IMP     protein poly-ADP-ribosylation GO:0070212 IDA     protein poly-ADP-ribosylation GO:0070212 IMP     protein auto-ADP-ribosylation GO:0070213 IDA     positive regulation of canonical Wnt signaling pathway GO:0090263 IBA     positive regulation of canonical Wnt signaling pathway GO:0090263 IMP     positive regulation of canonical Wnt signaling pathway GO:0090263 TAS     positive regulation of telomere capping GO:1904355 IBA     positive regulation of telomere capping GO:1904355 IMP     negative regulation of telomere maintenance via telomere lengthening GO:1904357 IMP     positive regulation of telomere maintenance via telomere lengthening GO:1904358 IDA     negative regulation of telomeric DNA binding GO:1904743 IDA     negative regulation of telomeric DNA binding GO:1904743 IMP     negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric GO:1904908 IMP Subcellular Localization     Golgi membrane GO:0000139 IEA     pericentriolar material GO:0000242 TAS     chromosome, telomeric region GO:0000781 IDA     nucleus GO:0005634 IBA     nuclear pore GO:0005643 TAS     nucleoplasm GO:0005654 IDA     cytoplasm GO:0005737 IBA     Golgi apparatus GO:0005794 IDA     cytosol GO:0005829 TAS     nuclear body GO:0016604 IDA     nuclear membrane GO:0031965 IDA     nuclear membrane GO:0031965 TAS     mitotic spindle pole GO:0097431 IDA