Gene description for TNKS
Gene name tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Gene symbol TNKS
Other names/aliases ARTD5
PARP-5a
PARP5A
PARPL
TIN1
TINF1
TNKS1
pART5
Species Homo sapiens
 Database cross references - TNKS
ExoCarta ExoCarta_8658
Vesiclepedia VP_8658
Entrez Gene 8658
HGNC 11941
MIM 603303
UniProt O95271  
 TNKS identified in sEVs derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for TNKS
Molecular Function
    NAD+-protein poly-ADP-ribosyltransferase activity GO:0003950 IBA
    NAD+-protein poly-ADP-ribosyltransferase activity GO:0003950 IDA
    NAD+-protein poly-ADP-ribosyltransferase activity GO:0003950 TAS
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IDA
    nucleotidyltransferase activity GO:0016779 IEA
    histone binding GO:0042393 IPI
    NAD+-protein-aspartate ADP-ribosyltransferase activity GO:0140806 IEA
    NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity GO:0140822 IEA
    NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity GO:0140844 IEA
    NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity GO:0140867 IEA
    NAD+-protein ADP-ribosyltransferase activity GO:1990404 IDA
Biological Process
    protein polyubiquitination GO:0000209 IDA
    mitotic spindle organization GO:0007052 TAS
    protein transport GO:0015031 IEA
    Wnt signaling pathway GO:0016055 IEA
    peptidyl-serine phosphorylation GO:0018105 IDA
    peptidyl-threonine phosphorylation GO:0018107 IDA
    regulation of telomere maintenance via telomerase GO:0032210 TAS
    positive regulation of telomere maintenance via telomerase GO:0032212 IDA
    positive regulation of telomere maintenance via telomerase GO:0032212 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    mRNA transport GO:0051028 IEA
    spindle assembly GO:0051225 TAS
    cell division GO:0051301 IEA
    protein localization to chromosome, telomeric region GO:0070198 IBA
    protein localization to chromosome, telomeric region GO:0070198 IMP
    protein poly-ADP-ribosylation GO:0070212 IDA
    protein poly-ADP-ribosylation GO:0070212 IMP
    protein auto-ADP-ribosylation GO:0070213 IDA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IBA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IMP
    positive regulation of canonical Wnt signaling pathway GO:0090263 TAS
    positive regulation of telomere capping GO:1904355 IBA
    positive regulation of telomere capping GO:1904355 IMP
    negative regulation of telomere maintenance via telomere lengthening GO:1904357 IMP
    positive regulation of telomere maintenance via telomere lengthening GO:1904358 IDA
    negative regulation of telomeric DNA binding GO:1904743 IDA
    negative regulation of telomeric DNA binding GO:1904743 IMP
    negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric GO:1904908 IMP
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    pericentriolar material GO:0000242 TAS
    chromosome, telomeric region GO:0000781 IDA
    nucleus GO:0005634 IBA
    nuclear pore GO:0005643 TAS
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 TAS
    nuclear body GO:0016604 IDA
    nuclear membrane GO:0031965 IDA
    nuclear membrane GO:0031965 TAS
    mitotic spindle pole GO:0097431 IDA
 Experiment description of studies that identified TNKS in sEVs
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for TNKS
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PAGE4  
Affinity Capture-MS Homo sapiens
2 PPP1R12B 4660
Affinity Capture-MS Homo sapiens
3 FTL 2512
Affinity Capture-MS Homo sapiens
4 PEX14 5195
Proximity Label-MS Homo sapiens
5 PPL 5493
Affinity Capture-MS Homo sapiens
6 DISC1 27185
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
7 NUMA1 4926
Reconstituted Complex Homo sapiens
8 TMEM44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 UIMC1  
Co-localization Homo sapiens
10 SDCBP 6386
Two-hybrid Homo sapiens
11 TERF2  
Affinity Capture-MS Homo sapiens
12 CCDC85A  
Affinity Capture-MS Homo sapiens
13 FANCD2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
14 RTN2 6253
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 POT1  
Affinity Capture-Western Homo sapiens
16 RNF166  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 AP2M1 1173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 XPO1 7514
Affinity Capture-MS Homo sapiens
19 TNKS 8658
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
20 PCDH9  
Affinity Capture-MS Homo sapiens
21 CEP170 9859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 MCL1 4170
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
23 MID1IP1  
Affinity Capture-MS Homo sapiens
24 SOST  
Affinity Capture-MS Homo sapiens
25 BLZF1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 ANKS3  
Affinity Capture-MS Homo sapiens
27 SLC35A5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 LRP1 4035
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 GAREM  
Affinity Capture-MS Homo sapiens
30 GMDS 2762
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
31 PTEN 5728
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
32 SH3BP5L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
33 TCL1A  
Two-hybrid Homo sapiens
34 EIF4A1 1973
Reconstituted Complex Homo sapiens
35 LNPEP 4012
Reconstituted Complex Homo sapiens
36 KLRG2 346689
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 STRN3 29966
Affinity Capture-MS Homo sapiens
38 ADPRHL2 54936
Two-hybrid Homo sapiens
39 MDC1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
40 CELF5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 MPDZ  
Affinity Capture-MS Homo sapiens
42 OARD1 221443
Two-hybrid Homo sapiens
43 Cct2 12461
Affinity Capture-MS Mus musculus
44 TNKS1BP1 85456
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
45 HIF1AN 55662
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 BABAM1 29086
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
47 RNF146  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
48 KIF20A 10112
Affinity Capture-MS Homo sapiens
49 PPP4R1L  
Affinity Capture-MS Homo sapiens
50 CHD1L 9557
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 TERF1 7013
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
52 UBASH3B 84959
Two-hybrid Homo sapiens
53 SH3BP5 9467
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
54 RAPGEF2 9693
Affinity Capture-MS Homo sapiens
55 SH3BP2  
Affinity Capture-Western Homo sapiens
56 AMOTL2 51421
Affinity Capture-Luminescence Homo sapiens
57 CGREF1 10669
Affinity Capture-MS Homo sapiens
58 EPN3 55040
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 EPM2AIP1 9852
Two-hybrid Homo sapiens
60 SSSCA1 10534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 MAPK8IP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 STK11 6794
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
63 AMOTL1 154810
Affinity Capture-Luminescence Homo sapiens
64 UPF3A  
Affinity Capture-MS Homo sapiens
65 AMOT 154796
Affinity Capture-Luminescence Homo sapiens
66 SLC9A8 23315
Affinity Capture-MS Homo sapiens
67 TNIK 23043
Two-hybrid Homo sapiens
68 FNBP1 23048
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
69 Tnks2  
Affinity Capture-MS Mus musculus
70 HOXB2  
Affinity Capture-MS Homo sapiens
71 NELFE 7936
Reconstituted Complex Homo sapiens
72 AXIN1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
73 TINF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 APC  
Affinity Capture-Western Homo sapiens
75 FAM117B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 CEP170P1  
Affinity Capture-MS Homo sapiens
77 WIBG 84305
Affinity Capture-MS Homo sapiens
78 ARHGEF40 55701
Affinity Capture-MS Homo sapiens
79 Blzf1 66352
Affinity Capture-MS Mus musculus
80 BRCA1 672
Co-localization Homo sapiens
81 USP25  
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
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