Gene description for FNBP1
Gene name formin binding protein 1
Gene symbol FNBP1
Other names/aliases FBP17
Species Homo sapiens
 Database cross references - FNBP1
ExoCarta ExoCarta_23048
Entrez Gene 23048
HGNC 17069
MIM 606191
UniProt Q96RU3  
 FNBP1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for FNBP1
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    lipid binding GO:0008289 IEA
Biological Process
    endocytosis GO:0006897 IEA
Subcellular Localization
    coated pit GO:0005905 IEA
    cell cortex GO:0005938 IEA
    lysosome GO:0005764 IEA
    plasma membrane GO:0005886 IEA
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified FNBP1 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FNBP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EGF 1950
Co-localization Homo sapiens
2 ARHGAP17 55114
Reconstituted Complex Homo sapiens
3 SNX2 6643
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
4 FNBP1 23048
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 DNM1 1759
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 FASLG 356
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 TF 7018
Co-localization Homo sapiens
8 AKAP9 10142
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 TNKS 8658
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
10 CTBS  
Co-localization Homo sapiens
View the network image/svg+xml
 Pathways in which FNBP1 is involved
No pathways found

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