Gene description for FNBP1L
Gene name formin binding protein 1-like
Gene symbol FNBP1L
Other names/aliases C1orf39
TOCA1
Species Homo sapiens
 Database cross references - FNBP1L
ExoCarta ExoCarta_54874
Entrez Gene 54874
HGNC 20851
MIM 608848
UniProt Q5T0N5  
 FNBP1L identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for FNBP1L
Molecular Function
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IEA
Biological Process
    vesicle transport along actin filament GO:0030050 IDA
    positive regulation of filopodium assembly GO:0051491 IDA
    membrane invagination GO:0010324 IDA
    membrane tubulation GO:0097320 IDA
    clathrin-mediated endocytosis GO:0072583 IDA
    membrane budding GO:0006900 IDA
    cilium assembly GO:0042384 IMP
    autophagy GO:0006914 IEA
    vesicle organization GO:0016050 IDA
Subcellular Localization
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IEA
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IDA
    cell cortex GO:0005938 IEA
    cytoplasmic membrane-bounded vesicle GO:0016023 IDA
 Experiment description of studies that identified FNBP1L in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FNBP1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 USP13  
Two-hybrid Homo sapiens
2 RUTBC1  
Two-hybrid Homo sapiens
3 CDC42 998
Affinity Capture-Western Homo sapiens
4 ACP1 52
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which FNBP1L is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here