Gene description for SBDS
Gene name Shwachman-Bodian-Diamond syndrome
Gene symbol SBDS
Other names/aliases CGI-97
SDS
SWDS
Species Homo sapiens
 Database cross references - SBDS
ExoCarta ExoCarta_51119
Entrez Gene 51119
HGNC 19440
MIM 607444
UniProt Q9Y3A5  
 SBDS identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SBDS
Molecular Function
    ribosome binding GO:0043022 IDA
    rRNA binding GO:0019843 IDA
    microtubule binding GO:0008017 IDA
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
Biological Process
    leukocyte chemotaxis GO:0030595 IDA
    mitotic spindle stabilization GO:0043148 IDA
    bone marrow development GO:0048539 IMP
    bone mineralization GO:0030282 IMP
    inner cell mass cell proliferation GO:0001833 IEA
    rRNA processing GO:0006364 IMP
    mature ribosome assembly GO:0042256 IDA
    cell proliferation GO:0008283 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    spindle pole GO:0000922 IDA
    nucleolus GO:0005730 IDA
 Experiment description of studies that identified SBDS in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SBDS
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SBDS is involved
No pathways found





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