Gene description for AHR
Gene name aryl hydrocarbon receptor
Gene symbol AHR
Other names/aliases bHLHe76
Species Homo sapiens
 Database cross references - AHR
ExoCarta ExoCarta_196
Entrez Gene 196
HGNC 348
MIM 600253
UniProt P35869  
 AHR identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for AHR
Molecular Function
    ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0004879 IDA
    enhancer binding GO:0035326 IDA
    protein binding GO:0005515 IPI
    E-box binding GO:0070888 ISS
    signal transducer activity GO:0004871 IEA
    sequence-specific DNA binding GO:0043565 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    protein heterodimerization activity GO:0046982 TAS
    DNA binding GO:0003677 TAS
    protein dimerization activity GO:0046983 TAS
    transcription factor binding GO:0008134 IPI
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity GO:0003705 IEA
    Hsp90 protein binding GO:0051879 IDA
    transcription regulatory region DNA binding GO:0044212 IDA
Biological Process
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    regulation of transcription from RNA polymerase II promoter GO:0006357 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IBA
    response to toxic substance GO:0009636 IDA
    negative regulation of transcription, DNA-templated GO:0045892 ISS
    regulation of transcription, DNA-templated GO:0006355 IDA
    positive regulation of transcription, DNA-templated GO:0045893 ISS
    response to xenobiotic stimulus GO:0009410 IDA
    apoptotic process GO:0006915 TAS
    transcription from RNA polymerase II promoter GO:0006366 IDA
    regulation of B cell proliferation GO:0030888 IDA
    prostate gland development GO:0030850 IEA
    blood vessel development GO:0001568 NAS
    circadian regulation of gene expression GO:0032922 ISS
    regulation of gene expression GO:0010468 IDA
    intracellular receptor signaling pathway GO:0030522 IDA
    cell cycle GO:0007049 IEA
    positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 IEA
    xenobiotic metabolic process GO:0006805 TAS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
    nuclear aryl hydrocarbon receptor complex GO:0034753 IBA
    nucleoplasm GO:0005654 IDA
    cytosolic aryl hydrocarbon receptor complex GO:0034752 TAS
    transcription factor complex GO:0005667 TAS
 Experiment description of studies that identified AHR in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for AHR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARNTL  
Invivo Homo sapiens
Two-hybrid Homo sapiens
2 RB1 5925
Invivo Homo sapiens
Invitro Homo sapiens
3 GTF2F2  
Reconstituted Complex Homo sapiens
4 SP1  
Reconstituted Complex Homo sapiens
5 ESR1  
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
6 PTGES3 10728
Invitro Homo sapiens
Invivo Homo sapiens
7 SRC 6714
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
8 NR2F1  
Invitro Homo sapiens
9 SMARCA4 6597
Reconstituted Complex Homo sapiens
10 NCOA2 10499
Affinity Capture-Western Homo sapiens
11 CCNT1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
12 DAP3  
Reconstituted Complex Homo sapiens
13 RELA  
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
14 NRIP1 8204
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
15 AIP  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
16 GTF2F1 2962
Reconstituted Complex Homo sapiens
17 HSP90AA1 3320
Invivo Homo sapiens
18 NEDD8 4738
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
19 XPO1 7514
Invivo Homo sapiens
Invitro Homo sapiens
20 ARNT 405
Invitro Homo sapiens
Two-hybrid Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
21 TBP  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which AHR is involved
No pathways found





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