Gene description for KIAA1598
Gene name KIAA1598
Gene symbol KIAA1598
Other names/aliases -
Species Homo sapiens
 Database cross references - KIAA1598
ExoCarta ExoCarta_57698
Vesiclepedia VP_57698
Entrez Gene 57698
HGNC 29319
MIM 611171
UniProt A0MZ66  
 KIAA1598 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for KIAA1598
Molecular Function
    protein binding GO:0005515 IPI
    kinesin binding GO:0019894 IEA
    identical protein binding GO:0042802 IPI
    cadherin binding GO:0045296 HDA
    actin filament binding GO:0051015 ISS
Biological Process
    substrate-dependent cell migration, cell extension GO:0006930 ISS
    Ras protein signal transduction GO:0007265 ISS
    axonogenesis GO:0007409 ISS
    Cdc42 protein signal transduction GO:0032488 ISS
    netrin-activated signaling pathway GO:0038007 ISS
    positive regulation of axon extension GO:0045773 ISS
    neuron projection morphogenesis GO:0048812 IBA
    neuron projection morphogenesis GO:0048812 ISS
    cytoplasmic actin-based contraction involved in cell motility GO:0060327 ISS
    endoplasmic reticulum polarization GO:0061163 ISS
    actin filament bundle retrograde transport GO:0061573 ISS
    regulation of establishment of cell polarity GO:2000114 ISS
    positive regulation of neuron migration GO:2001224 IBA
    positive regulation of neuron migration GO:2001224 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    microtubule GO:0005874 IDA
    microtubule associated complex GO:0005875 ISS
    microtubule cytoskeleton GO:0015630 ISS
    lamellipodium GO:0030027 ISS
    filopodium GO:0030175 ISS
    axon GO:0030424 ISS
    growth cone GO:0030426 ISS
    cell leading edge GO:0031252 IBA
    cell leading edge GO:0031252 ISS
    perikaryon GO:0043204 ISS
    axonal growth cone GO:0044295 IBA
    axonal growth cone GO:0044295 ISS
    perinuclear region of cytoplasm GO:0048471 ISS
 Experiment description of studies that identified KIAA1598 in exosomes
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KIAA1598
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 FABP3 2170
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 TNIP1 10318
Two-hybrid Homo sapiens
4 RAB1A 5861
Co-fractionation Homo sapiens
5 FAM167A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 YWHAE 7531
Affinity Capture-MS Homo sapiens
7 CAP1 10487
Co-fractionation Homo sapiens
8 ACTC1 70
Proximity Label-MS Homo sapiens
9 C9orf78 51759
Affinity Capture-MS Homo sapiens
10 TRMT6 51605
Co-fractionation Homo sapiens
11 ESRRG  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
12 MRPL49 740
Affinity Capture-MS Homo sapiens
13 VPS29 51699
Co-fractionation Homo sapiens
14 KIAA1598 57698
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 CAPZB 832
Co-fractionation Homo sapiens
16 NME7 29922
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
17 TSNAX 7257
Co-fractionation Homo sapiens
18 ABCC12  
Affinity Capture-MS Homo sapiens
19 ANKRD49  
Affinity Capture-MS Homo sapiens
20 IMPDH2 3615
Co-fractionation Homo sapiens
21 BBOX1 8424
Two-hybrid Homo sapiens
22 FBL 2091
Affinity Capture-MS Homo sapiens
23 HSP90B1 7184
Co-fractionation Homo sapiens
24 TFCP2 7024
Two-hybrid Homo sapiens
25 NEDD4 4734
Reconstituted Complex Homo sapiens
26 YWHAB 7529
Affinity Capture-MS Homo sapiens
27 GTF2I 2969
Co-fractionation Homo sapiens
28 CAV3 859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 PFN1 5216
Proximity Label-MS Homo sapiens
30 MAPK8IP3  
Affinity Capture-MS Homo sapiens
31 RNF41  
Affinity Capture-MS Homo sapiens
32 CAPZA1 829
Co-fractionation Homo sapiens
33 PSME1 5720
Co-fractionation Homo sapiens
34 SRSF3 6428
Co-fractionation Homo sapiens
35 LURAP1L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 NT5DC2 64943
Co-fractionation Homo sapiens
37 ZCCHC17  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
38 CDH1 999
Proximity Label-MS Homo sapiens
39 IGL 3535
Two-hybrid Homo sapiens
40 BBS1 582
Affinity Capture-MS Homo sapiens
41 OR4E2  
Affinity Capture-MS Homo sapiens
42 RRM1 6240
Co-fractionation Homo sapiens
43 NTRK1 4914
Affinity Capture-MS Homo sapiens
44 FAM24B  
Affinity Capture-MS Homo sapiens
45 BCHE 590
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 TEX30  
Affinity Capture-MS Homo sapiens
47 EXOC6B 23233
Two-hybrid Homo sapiens
48 ACTB 60
Proximity Label-MS Homo sapiens
49 SMS 6611
Co-fractionation Homo sapiens
50 Kif20b  
Affinity Capture-MS Mus musculus
51 SP2  
Affinity Capture-MS Homo sapiens
52 PHLPP1  
Proximity Label-MS Homo sapiens
53 NUMA1 4926
Co-fractionation Homo sapiens
54 HSPA5 3309
Co-fractionation Homo sapiens
55 ZBTB2 57621
Affinity Capture-MS Homo sapiens
56 AHCYL1 10768
Co-fractionation Homo sapiens
57 KCTD12 115207
Co-fractionation Homo sapiens
58 DOK4 55715
Affinity Capture-MS Homo sapiens
59 HDDC3  
Affinity Capture-MS Homo sapiens
60 YWHAZ 7534
Affinity Capture-MS Homo sapiens
61 SEC24A 10802
Co-fractionation Homo sapiens
62 FASN 2194
Co-fractionation Homo sapiens
63 TPM1 7168
Co-fractionation Homo sapiens
64 UBA2 10054
Co-fractionation Homo sapiens
65 AHR 196
Affinity Capture-MS Homo sapiens
66 HSPA1A 3303
Affinity Capture-MS Homo sapiens
67 CSDE1 7812
Co-fractionation Homo sapiens
68 TPM4 7171
Co-fractionation Homo sapiens
69 UBXN1 51035
Co-fractionation Homo sapiens
70 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
71 TP53BP2  
Two-hybrid Homo sapiens
72 PSAT1 29968
Co-fractionation Homo sapiens
73 IKBKG 8517
Reconstituted Complex Homo sapiens
74 RNF20 56254
Co-fractionation Homo sapiens
75 OTUB1 55611
Co-fractionation Homo sapiens
76 SIRT1  
Co-fractionation Homo sapiens
77 UNK  
Co-fractionation Homo sapiens
78 PCNA 5111
Co-fractionation Homo sapiens
79 TXN 7295
Co-fractionation Homo sapiens
80 OGFR 11054
Co-fractionation Homo sapiens
81 PSMA5 5686
Co-fractionation Homo sapiens
82 NDEL1 81565
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 COLGALT1 79709
Co-fractionation Homo sapiens
84 ARHGAP35 2909
Co-fractionation Homo sapiens
85 PSMC4 5704
Affinity Capture-MS Homo sapiens
86 LNX1  
Reconstituted Complex Homo sapiens
87 CNDP2 55748
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which KIAA1598 is involved
PathwayEvidenceSource
Axon guidance IEA Reactome
Developmental Biology IEA Reactome
L1CAM interactions IEA Reactome
Nervous system development IEA Reactome
Recycling pathway of L1 IEA Reactome





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