Gene description for RNF20
Gene name ring finger protein 20, E3 ubiquitin protein ligase
Gene symbol RNF20
Other names/aliases BRE1
BRE1A
hBRE1
Species Homo sapiens
 Database cross references - RNF20
ExoCarta ExoCarta_56254
Entrez Gene 56254
HGNC 10062
MIM 607699
UniProt Q5VTR2  
 RNF20 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for RNF20
Molecular Function
    protein binding GO:0005515 IPI
    ligase activity GO:0016874 IEA
    ubiquitin-protein transferase activity GO:0004842 IDA
    chromatin binding GO:0003682 IEA
    histone binding GO:0042393 IDA
    mRNA 3'-UTR binding GO:0003730 IDA
    zinc ion binding GO:0008270 IEA
    p53 binding GO:0002039 IDA
    transcription coactivator activity GO:0003713 IDA
    ubiquitin protein ligase binding GO:0031625 IPI
Biological Process
    negative regulation of mRNA polyadenylation GO:1900364 IMP
    protein polyubiquitination GO:0000209 IDA
    regulation of transcription, DNA-templated GO:0006355 IMP
    negative regulation of cell migration GO:0030336 IDA
    ubiquitin-dependent protein catabolic process GO:0006511 IMP
    histone H2B ubiquitination GO:0033523 IDA
    positive regulation of histone methylation GO:0031062 IEA
    positive regulation of histone H2B ubiquitination GO:2001168 IMP
    positive regulation of transcription, DNA-templated GO:0045893 IMP
    histone monoubiquitination GO:0010390 IDA
    regulation of mitotic cell cycle GO:0007346 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleolus GO:0005730 IDA
    ubiquitin ligase complex GO:0000151 IDA
    HULC complex GO:0033503 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified RNF20 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RNF20
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RNF20 is involved
No pathways found





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