Gene description for TXNDC5
Gene name thioredoxin domain containing 5 (endoplasmic reticulum)
Gene symbol TXNDC5
Other names/aliases ENDOPDI
ERP46
HCC-2
PDIA15
STRF8
UNQ364
Species Homo sapiens
 Database cross references - TXNDC5
ExoCarta ExoCarta_81567
Entrez Gene 81567
HGNC 21073
UniProt Q8NBS9  
 TXNDC5 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Saliva 19199708    
 Gene ontology annotations for TXNDC5
Molecular Function
    protein disulfide isomerase activity GO:0003756 IBA
    protein binding GO:0005515 IPI
Biological Process
    post-Golgi vesicle-mediated transport GO:0006892 TAS
    cell redox homeostasis GO:0045454 IEA
    membrane organization GO:0061024 TAS
    response to endoplasmic reticulum stress GO:0034976 IBA
    protein folding GO:0006457 IBA
    apoptotic cell clearance GO:0043277 IBA
    negative regulation of apoptotic process GO:0043066 TAS
Subcellular Localization
    lysosomal lumen GO:0043202 TAS
    extracellular exosome GO:0070062 IDA
    endoplasmic reticulum lumen GO:0005788 IEA
    endoplasmic reticulum GO:0005783 TAS
 Experiment description of studies that identified TXNDC5 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for TXNDC5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TXNDC5 is involved
PathwayEvidenceSource
Golgi Associated Vesicle Biogenesis TAS Reactome
Lysosome Vesicle Biogenesis TAS Reactome





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