Gene description for SOS1
Gene name son of sevenless homolog 1 (Drosophila)
Gene symbol SOS1
Other names/aliases GF1
GGF1
GINGF
HGF
NS4
Species Homo sapiens
 Database cross references - SOS1
ExoCarta ExoCarta_6654
Vesiclepedia VP_6654
Entrez Gene 6654
HGNC 11187
MIM 182530
UniProt Q07889  
 SOS1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SOS1
Molecular Function
    GTPase activator activity GO:0005096 TAS
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IEA
    Rho guanyl-nucleotide exchange factor activity GO:0005089 IEA
    SH3 domain binding GO:0017124 IEA
    Ras guanyl-nucleotide exchange factor activity GO:0005088 TAS
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    positive regulation of small GTPase mediated signal transduction GO:0051057 IEA
    blood coagulation GO:0007596 TAS
    small GTPase mediated signal transduction GO:0007264 TAS
    leukocyte migration GO:0050900 TAS
    positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 IEA
    platelet activation GO:0030168 TAS
    positive regulation of GTPase activity GO:0043547 TAS
    axon guidance GO:0007411 TAS
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    apoptotic signaling pathway GO:0097190 TAS
    innate immune response GO:0045087 TAS
    insulin receptor signaling pathway GO:0008286 TAS
    positive regulation of apoptotic process GO:0043065 TAS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    signal transduction GO:0007165 NAS
    Ras protein signal transduction GO:0007265 TAS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    neuronal cell body GO:0043025 IEA
    cytosol GO:0005829 TAS
    postsynaptic density GO:0014069 IEA
 Experiment description of studies that identified SOS1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SOS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ABI1 10006
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 NCK1 4690
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
3 FRS2 10818
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
4 ITSN1 6453
Invivo Homo sapiens
Invitro Homo sapiens
5 GRB2 2885
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
6 SHC1 6464
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
7 RIT2  
Invivo Homo sapiens
8 NF2 4771
Affinity Capture-Western Homo sapiens
9 GRAP  
Invitro Homo sapiens
10 HRAS 3265
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
11 Grap2 17444
Reconstituted Complex Mus musculus
12 ABL1 25
Affinity Capture-Western Homo sapiens
13 EPS8 2059
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
14 EGFR 1956
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 ERBB3 2065
Invivo Homo sapiens
Invitro Homo sapiens
16 NCK2 8440
Invivo Homo sapiens
Invitro Homo sapiens
17 EPS8L2 64787
Affinity Capture-Western Homo sapiens
18 FYN 2534
Invitro Homo sapiens
19 CRKL 1399
Invivo Homo sapiens
20 CRK 1398
Invivo Homo sapiens
Invitro Homo sapiens
21 ERBB2 2064
Invivo Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
22 MUC1 4582
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
23 SH3KBP1 30011
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 EPS8L1 54869
Affinity Capture-Western Homo sapiens
25 PLCG1 5335
Invitro Homo sapiens
26 ATP6V1E1 529
Invitro Homo sapiens
Invivo Homo sapiens
27 BCR 613
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SOS1 is involved
PathwayEvidenceSource
Activation of Rac TAS Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers TAS Reactome
Constitutive Signaling by EGFRvIII TAS Reactome
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants TAS Reactome
DAP12 signaling TAS Reactome
Downstream signal transduction TAS Reactome
EGFR Transactivation by Gastrin TAS Reactome
FCERI mediated Ca+2 mobilization TAS Reactome
FCERI mediated MAPK activation TAS Reactome
FRS-mediated FGFR1 signaling TAS Reactome
FRS-mediated FGFR2 signaling TAS Reactome
FRS-mediated FGFR3 signaling TAS Reactome
FRS2-mediated FGFR4 signaling TAS Reactome
G alpha (12/13) signalling events TAS Reactome
GRB2 events in EGFR signaling TAS Reactome
GRB2 events in ERBB2 signaling TAS Reactome
GRB2:SOS provides linkage to MAPK signaling for Integrins TAS Reactome
Interleukin receptor SHC signaling TAS Reactome
Interleukin receptor SHC signaling TAS Reactome
NCAM signaling for neurite out-growth TAS Reactome
NRAGE signals death through JNK TAS Reactome
Regulation of KIT signaling TAS Reactome
Rho GTPase cycle TAS Reactome
Role of LAT2/NTAL/LAB on calcium mobilization TAS Reactome
SHC-mediated cascade:FGFR1 TAS Reactome
SHC-mediated cascade:FGFR2 TAS Reactome
SHC-mediated cascade:FGFR3 TAS Reactome
SHC-mediated cascade:FGFR4 TAS Reactome
SHC-mediated signalling TAS Reactome
SHC-mediated signalling TAS Reactome
SHC1 events in EGFR signaling TAS Reactome
SHC1 events in ERBB2 signaling TAS Reactome
SHC1 events in ERBB4 signaling TAS Reactome
Signal attenuation TAS Reactome
Signaling by FGFR1 mutants TAS Reactome
Signaling by FGFR2 mutants TAS Reactome
Signaling by FGFR3 mutants TAS Reactome
Signaling by FGFR4 mutants TAS Reactome
Signaling by SCF-KIT TAS Reactome
Signalling to RAS TAS Reactome
SOS-mediated signalling TAS Reactome
SOS-mediated signalling TAS Reactome
Tie2 Signaling TAS Reactome





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