Gene description for SOS1
Gene name son of sevenless homolog 1 (Drosophila)
Gene symbol SOS1
Other names/aliases GF1
GGF1
GINGF
HGF
NS4
Species Homo sapiens
 Database cross references - SOS1
ExoCarta ExoCarta_6654
Vesiclepedia VP_6654
Entrez Gene 6654
HGNC 11187
MIM 182530
UniProt Q07889  
 SOS1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SOS1
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 EXP
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    guanyl-nucleotide exchange factor activity GO:0005085 IDA
    guanyl-nucleotide exchange factor activity GO:0005085 TAS
    GTPase activator activity GO:0005096 TAS
    epidermal growth factor receptor binding GO:0005154 IEA
    protein binding GO:0005515 IPI
    SH3 domain binding GO:0017124 IEA
    protein kinase binding GO:0019901 IEA
    protein heterodimerization activity GO:0046982 IEA
    molecular condensate scaffold activity GO:0140693 IDA
Biological Process
    B cell homeostasis GO:0001782 IEA
    hair follicle development GO:0001942 IEA
    response to ischemia GO:0002931 IEA
    cardiac atrium morphogenesis GO:0003209 IEA
    pericardium morphogenesis GO:0003344 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    signal transduction GO:0007165 NAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    Ras protein signal transduction GO:0007265 IBA
    Ras protein signal transduction GO:0007265 IDA
    vitellogenesis GO:0007296 IEA
    axon guidance GO:0007411 TAS
    insulin receptor signaling pathway GO:0008286 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 IEA
    Schwann cell development GO:0014044 IEA
    cytokine-mediated signaling pathway GO:0019221 TAS
    regulation of T cell differentiation in thymus GO:0033081 IEA
    multicellular organism growth GO:0035264 IEA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    T cell activation GO:0042110 IDA
    regulation of cell population proliferation GO:0042127 IDA
    regulation of T cell proliferation GO:0042129 IEA
    myelination GO:0042552 IEA
    positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 IEA
    insulin-like growth factor receptor signaling pathway GO:0048009 IEA
    neurotrophin TRK receptor signaling pathway GO:0048011 IEA
    blood vessel morphogenesis GO:0048514 IEA
    B cell receptor signaling pathway GO:0050853 IEA
    leukocyte migration GO:0050900 TAS
    positive regulation of small GTPase mediated signal transduction GO:0051057 IEA
    roof of mouth development GO:0060021 IEA
    eyelid development in camera-type eye GO:0061029 IEA
    heart trabecula morphogenesis GO:0061384 IEA
    midbrain morphogenesis GO:1904693 IEA
    regulation of pro-B cell differentiation GO:2000973 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    postsynaptic density GO:0014069 IEA
    neuronal cell body GO:0043025 IEA
    glutamatergic synapse GO:0098978 IEA
    GTPase complex GO:1905360 IPI
 Experiment description of studies that identified SOS1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SOS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ptk2b  
Affinity Capture-Western Rattus norvegicus
2 C12orf49  
Positive Genetic Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 Bin1  
Two-hybrid Mus musculus
5 SPTAN1 6709
Two-hybrid Homo sapiens
6 TNFRSF1A 7132
Affinity Capture-Western Homo sapiens
7 LAT 27040
Co-localization Homo sapiens
8 PTPN11 5781
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 GAB1  
Co-localization Homo sapiens
10 EFNA4  
Affinity Capture-MS Homo sapiens
11 NCK1 4690
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
12 CRKL 1399
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
13 ITSN1 6453
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
14 GRB2 2885
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
15 SHC1 6464
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
16 SRRM1 10250
Affinity Capture-MS Homo sapiens
17 LRRK1 79705
Affinity Capture-MS Homo sapiens
18 SORBS1 10580
Affinity Capture-Western Homo sapiens
19 ANXA2 302
Reconstituted Complex Homo sapiens
20 PTPN6 5777
Affinity Capture-Western Homo sapiens
21 NF2 4771
Affinity Capture-Western Homo sapiens
22 NME2 4831
Affinity Capture-MS Homo sapiens
23 SIRPA 140885
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
24 BRD8 10902
Affinity Capture-MS Homo sapiens
25 LCK 3932
Protein-peptide Homo sapiens
26 GRAP  
Co-fractionation Homo sapiens
27 HRAS 3265
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
28 CETN3  
Affinity Capture-MS Homo sapiens
29 Grap2 17444
Reconstituted Complex Mus musculus
30 ABL1 25
Affinity Capture-Western Homo sapiens
31 EPS8 2059
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
32 EGFR 1956
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
33 CAPZB 832
Affinity Capture-MS Homo sapiens
34 HCK 3055
Co-localization Homo sapiens
35 EPS15L1 58513
Affinity Capture-MS Homo sapiens
36 NCK2 8440
Affinity Capture-Western Homo sapiens
37 PSMD14 10213
Affinity Capture-MS Homo sapiens
38 CBL 867
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
39 FGFR1 2260
Co-localization Homo sapiens
40 EPS8L2 64787
Affinity Capture-Western Homo sapiens
41 ITSN2 50618
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
42 SH3BP5 9467
Two-hybrid Homo sapiens
43 C3orf18  
Affinity Capture-MS Homo sapiens
44 EPS8L1 54869
Affinity Capture-Western Homo sapiens
45 RIT2  
Affinity Capture-Western Homo sapiens
46 NTRK1 4914
Affinity Capture-MS Homo sapiens
47 FRS2 10818
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
48 CRK 1398
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
49 EFNA3  
Affinity Capture-MS Homo sapiens
50 CD2AP 23607
Affinity Capture-MS Homo sapiens
51 HDLBP 3069
Two-hybrid Homo sapiens
52 MET 4233
Affinity Capture-Western Homo sapiens
53 MUC1 4582
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
54 Arhgap18  
Affinity Capture-MS Mus musculus
55 TNIK 23043
Two-hybrid Homo sapiens
56 FYN 2534
Reconstituted Complex Homo sapiens
57 SH3KBP1 30011
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
58 TXNDC5 81567
Affinity Capture-MS Homo sapiens
59 KRAS 3845
Synthetic Lethality Homo sapiens
60 RAC1 5879
Affinity Capture-Western Homo sapiens
61 ABI1 10006
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
62 PLCG1 5335
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
63 UBASH3A 53347
Two-hybrid Homo sapiens
64 CSF1R  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
65 PIK3R1 5295
Co-localization Homo sapiens
Co-fractionation Homo sapiens
66 BIN1 274
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
67 BCR 613
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SOS1 is involved
PathwayEvidenceSource
Activated NTRK2 signals through FRS2 and FRS3 TAS Reactome
Activated NTRK2 signals through FRS2 and FRS3 IEA Reactome
Activated NTRK2 signals through RAS IEA Reactome
Activated NTRK3 signals through RAS IEA Reactome
Activation of RAC1 IEA Reactome
Adaptive Immune System TAS Reactome
Adaptive Immune System IEA Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers TAS Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IEA Reactome
Axon guidance IEA Reactome
Axon guidance TAS Reactome
Cell death signalling via NRAGE, NRIF and NADE TAS Reactome
Cell surface interactions at the vascular wall TAS Reactome
Constitutive Signaling by EGFRvIII TAS Reactome
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants TAS Reactome
Constitutive Signaling by Overexpressed ERBB2 TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
DAP12 interactions TAS Reactome
DAP12 signaling TAS Reactome
Death Receptor Signaling TAS Reactome
Developmental Biology IEA Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downstream signal transduction TAS Reactome
Downstream signaling of activated FGFR1 TAS Reactome
Downstream signaling of activated FGFR2 TAS Reactome
Downstream signaling of activated FGFR3 TAS Reactome
Downstream signaling of activated FGFR4 TAS Reactome
EGFR Transactivation by Gastrin TAS Reactome
Erythropoietin activates RAS IEA Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
Fc epsilon receptor (FCERI) signaling IEA Reactome
FCERI mediated Ca+2 mobilization IEA Reactome
FCERI mediated Ca+2 mobilization TAS Reactome
FCERI mediated MAPK activation TAS Reactome
FLT3 Signaling TAS Reactome
FLT3 signaling in disease TAS Reactome
FRS-mediated FGFR1 signaling TAS Reactome
FRS-mediated FGFR2 signaling TAS Reactome
FRS-mediated FGFR3 signaling TAS Reactome
FRS-mediated FGFR4 signaling TAS Reactome
G alpha (12/13) signalling events TAS Reactome
G alpha (q) signalling events TAS Reactome
Gastrin-CREB signalling pathway via PKC and MAPK TAS Reactome
GPCR downstream signalling TAS Reactome
GRB2 events in EGFR signaling TAS Reactome
GRB2 events in ERBB2 signaling TAS Reactome
GRB2 events in ERBB2 signaling IEA Reactome
GRB2:SOS provides linkage to MAPK signaling for Integrins TAS Reactome
Hemostasis TAS Reactome
IGF1R signaling cascade TAS Reactome
IGF1R signaling cascade IEA Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Innate Immune System IEA Reactome
Insulin receptor signalling cascade TAS Reactome
Insulin receptor signalling cascade IEA Reactome
Integrin signaling TAS Reactome
Interleukin receptor SHC signaling TAS Reactome
Interleukin-15 signaling TAS Reactome
Interleukin-2 family signaling TAS Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling TAS Reactome
IRS-mediated signalling TAS Reactome
IRS-mediated signalling IEA Reactome
IRS-related events triggered by IGF1R TAS Reactome
IRS-related events triggered by IGF1R IEA Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
MET activates RAS signaling TAS Reactome
NCAM signaling for neurite out-growth TAS Reactome
Nervous system development IEA Reactome
Nervous system development TAS Reactome
NRAGE signals death through JNK TAS Reactome
p75 NTR receptor-mediated signalling TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet Aggregation (Plug Formation) TAS Reactome
Potential therapeutics for SARS TAS Reactome
RAC1 GTPase cycle TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Regulation of KIT signaling TAS Reactome
RET signaling TAS Reactome
RHO GTPase cycle TAS Reactome
Role of LAT2/NTAL/LAB on calcium mobilization TAS Reactome
Role of LAT2/NTAL/LAB on calcium mobilization IEA Reactome
SARS-CoV Infections TAS Reactome
SHC-mediated cascade:FGFR1 TAS Reactome
SHC-mediated cascade:FGFR2 TAS Reactome
SHC-mediated cascade:FGFR3 TAS Reactome
SHC-mediated cascade:FGFR4 TAS Reactome
SHC-related events triggered by IGF1R TAS Reactome
SHC-related events triggered by IGF1R IEA Reactome
SHC1 events in EGFR signaling TAS Reactome
SHC1 events in ERBB2 signaling IEA Reactome
SHC1 events in ERBB4 signaling TAS Reactome
Signal attenuation TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by CSF1 (M-CSF) in myeloid cells IEA Reactome
Signaling by EGFR TAS Reactome
Signaling by EGFR in Cancer TAS Reactome
Signaling by EGFRvIII in Cancer TAS Reactome
Signaling by ERBB2 TAS Reactome
Signaling by ERBB2 IEA Reactome
Signaling by ERBB2 ECD mutants TAS Reactome
Signaling by ERBB2 in Cancer TAS Reactome
Signaling by ERBB2 KD Mutants TAS Reactome
Signaling by ERBB2 TMD/JMD mutants TAS Reactome
Signaling by ERBB4 TAS Reactome
Signaling by Erythropoietin IEA Reactome
Signaling by FGFR TAS Reactome
Signaling by FGFR in disease TAS Reactome
Signaling by FGFR1 TAS Reactome
Signaling by FGFR1 in disease TAS Reactome
Signaling by FGFR2 TAS Reactome
Signaling by FGFR2 in disease TAS Reactome
Signaling by FGFR3 TAS Reactome
Signaling by FGFR3 in disease TAS Reactome
Signaling by FGFR4 TAS Reactome
Signaling by FGFR4 in disease TAS Reactome
Signaling by FLT3 fusion proteins TAS Reactome
Signaling by FLT3 ITD and TKD mutants TAS Reactome
Signaling by GPCR TAS Reactome
Signaling by Insulin receptor TAS Reactome
Signaling by Insulin receptor IEA Reactome
Signaling by Interleukins TAS Reactome
Signaling by KIT in disease TAS Reactome
Signaling by Ligand-Responsive EGFR Variants in Cancer TAS Reactome
Signaling by LTK TAS Reactome
Signaling by MET TAS Reactome
Signaling by NTRK1 (TRKA) TAS Reactome
Signaling by NTRK1 (TRKA) IEA Reactome
Signaling by NTRK2 (TRKB) TAS Reactome
Signaling by NTRK2 (TRKB) IEA Reactome
Signaling by NTRK3 (TRKC) IEA Reactome
Signaling by NTRKs TAS Reactome
Signaling by NTRKs IEA Reactome
Signaling by PDGF TAS Reactome
Signaling by PDGFR in disease TAS Reactome
Signaling by PDGFRA extracellular domain mutants TAS Reactome
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants TAS Reactome
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by ROBO receptors IEA Reactome
Signaling by SCF-KIT TAS Reactome
Signaling by the B Cell Receptor (BCR) TAS Reactome
Signaling by the B Cell Receptor (BCR) IEA Reactome
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) TAS Reactome
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IEA Reactome
Signalling to ERKs TAS Reactome
Signalling to ERKs IEA Reactome
Signalling to RAS TAS Reactome
Signalling to RAS IEA Reactome
SOS-mediated signalling TAS Reactome
SOS-mediated signalling IEA Reactome
Tie2 Signaling TAS Reactome
Viral Infection Pathways TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here