Gene description for LAT
Gene name
linker for activation of T cells
Gene symbol
LAT
Other names/aliases
LAT1 pp36
Species
Homo sapiens
Database cross references - LAT
ExoCarta
ExoCarta_27040
Entrez Gene
27040
HGNC
18874
MIM
602354
UniProt
O43561
LAT identified in exosomes derived from the following tissue/cell type
Platelets
25332113
Platelets
25332113
Platelets
25332113
Thymus
23844026
Gene ontology annotations for LAT
Experiment description of studies that identified LAT in exosomes
1
Experiment ID
231
ISEV standards
✘
EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 1
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein Lipids
Methods used in the study
Western blotting Mass spectrometry
2
Experiment ID
232
ISEV standards
✘
EV Biophysical techniques
✘
EV Cytosolic markers
✘
EV Membrane markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 2
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
3
Experiment ID
233
ISEV standards
✘
EV Biophysical techniques
✘
EV Cytosolic markers
✘
EV Membrane markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25332113
Organism
Homo sapiens
Experiment description
Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors
Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name
Transfusion
Publication year
2015
Sample
Platelets
Sample name
PL-Exs - Rep 3
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient
Flotation density
1.12-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
4
Experiment ID
217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23844026
Organism
Homo sapiens
Experiment description
Characterization of human thymic exosomes.
Authors
Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name
PLoS One
Publication year
2013
Sample
Thymus
Sample name
Normal-Thymus
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for LAT
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
PIK3R1
5295
Affinity Capture-Western
Homo sapiens
Reconstituted Complex
Homo sapiens
2
PTPRJ
5795
Invitro
Homo sapiens
3
CD4
920
Affinity Capture-MS
Homo sapiens
Invivo
Homo sapiens
4
FCGR1A
Affinity Capture-MS
Homo sapiens
Invivo
Homo sapiens
5
CD8A
925
Invivo
Homo sapiens
6
SYK
6850
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
Biochemical Activity
Homo sapiens
7
CLYBL
Affinity Capture-Western
Homo sapiens
8
PLCG1
5335
Co-fractionation
Homo sapiens
Affinity Capture-Western
Homo sapiens
Reconstituted Complex
Homo sapiens
9
GAB2
9846
Affinity Capture-Western
Homo sapiens
10
PLCG2
5336
Affinity Capture-MS
Homo sapiens
Invitro
Homo sapiens
11
SH3BP2
Reconstituted Complex
Homo sapiens
Affinity Capture-Western
Homo sapiens
12
VAV1
7409
Reconstituted Complex
Homo sapiens
13
GRB2
2885
Affinity Capture-MS
Homo sapiens
Invivo
Homo sapiens
Invitro
Homo sapiens
Invivo
Homo sapiens
Invivo
Homo sapiens
Affinity Capture-Western
Homo sapiens
14
FCGR2A
2212
Affinity Capture-MS
Homo sapiens
Invivo
Homo sapiens
15
ITK
3702
Invitro
Homo sapiens
Affinity Capture-Western
Homo sapiens
16
SLA
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
17
GRAP2
9402
Invivo
Homo sapiens
Affinity Capture-MS
Homo sapiens
18
LCP2
3937
Affinity Capture-MS
Homo sapiens
Invivo
Homo sapiens
19
SHB
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
20
ZAP70
7535
Biochemical Activity
Homo sapiens
View the network
image/svg+xml
Pathways in which LAT is involved