Gene description for USP19
Gene name ubiquitin specific peptidase 19
Gene symbol USP19
Other names/aliases ZMYND9
Species Homo sapiens
 Database cross references - USP19
ExoCarta ExoCarta_10869
Vesiclepedia VP_10869
Entrez Gene 10869
HGNC 12617
MIM 614471
UniProt O94966  
 USP19 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for USP19
Molecular Function
    cysteine-type deubiquitinase activity GO:0004843 IDA
    cysteine-type deubiquitinase activity GO:0004843 IMP
    cysteine-type deubiquitinase activity GO:0004843 TAS
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    Hsp90 protein binding GO:0051879 IDA
Biological Process
    protein deubiquitination GO:0016579 IMP
    protein deubiquitination GO:0016579 ISS
    protein deubiquitination GO:0016579 TAS
    regulation of protein stability GO:0031647 IBA
    regulation of protein stability GO:0031647 ISS
    response to endoplasmic reticulum stress GO:0034976 IEP
    ERAD pathway GO:0036503 IBA
    ERAD pathway GO:0036503 IDA
    negative regulation of skeletal muscle tissue development GO:0048642 ISS
    protein stabilization GO:0050821 IMP
    positive regulation of cell cycle process GO:0090068 ISS
    regulation of cellular response to hypoxia GO:1900037 IMP
    regulation of ERAD pathway GO:1904292 IMP
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified USP19 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for USP19
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
2 ATAD1 84896
Affinity Capture-MS Homo sapiens
3 PDHA1 5160
Affinity Capture-MS Homo sapiens
4 PAH 5053
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
5 XIAP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 HDAC2 3066
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
7 SEC61A2 55176
Affinity Capture-MS Homo sapiens
8 SIAH2 6478
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
9 SRPRB 58477
Affinity Capture-MS Homo sapiens
10 CRYL1 51084
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 UBC 7316
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
12 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
13 XRN2 22803
Co-fractionation Homo sapiens
14 SYVN1 84447
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 PARK7 11315
Affinity Capture-MS Homo sapiens
16 GCN1L1 10985
Affinity Capture-MS Homo sapiens
17 NUP160 23279
Affinity Capture-MS Homo sapiens
18 FAM83F 113828
Affinity Capture-MS Homo sapiens
19 LRPPRC 10128
Affinity Capture-MS Homo sapiens
20 MAP1LC3B 81631
Affinity Capture-Western Homo sapiens
21 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
22 RFXANK  
Affinity Capture-MS Homo sapiens
23 TLN1 7094
Co-fractionation Homo sapiens
24 SEL1L 6400
Affinity Capture-Western Homo sapiens
25 EWSR1 2130
Affinity Capture-Western Homo sapiens
26 PPP2R5B 5526
Affinity Capture-MS Homo sapiens
27 HERC2 8924
Affinity Capture-MS Homo sapiens
28 ATG7 10533
Affinity Capture-MS Homo sapiens
29 BIRC3 330
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
30 DNAJC7 7266
Affinity Capture-MS Homo sapiens
31 MAVS 57506
Affinity Capture-Western Homo sapiens
32 KPTN  
Affinity Capture-MS Homo sapiens
33 USP7 7874
Affinity Capture-MS Homo sapiens
34 FAF2 23197
Affinity Capture-Western Homo sapiens
35 FKBPL  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
36 HSPA8 3312
Affinity Capture-Western Homo sapiens
37 PIK3C3 5289
Affinity Capture-Western Homo sapiens
38 UNC45A 55898
Affinity Capture-MS Homo sapiens
39 CYP2W1  
Affinity Capture-MS Homo sapiens
40 SLC1A5 6510
Affinity Capture-MS Homo sapiens
41 RORC 6097
Affinity Capture-Western Homo sapiens
42 FKBP6  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 B4GALT2  
Affinity Capture-MS Homo sapiens
44 TRIM21 6737
Affinity Capture-MS Homo sapiens
45 NTRK1 4914
Affinity Capture-MS Homo sapiens
46 TNPO3 23534
Affinity Capture-MS Homo sapiens
47 ULK1  
Affinity Capture-Western Homo sapiens
48 TTC9C 283237
Affinity Capture-MS Homo sapiens
49 AIP 9049
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
50 IARS 3376
Affinity Capture-MS Homo sapiens
51 TMEM33 55161
Affinity Capture-MS Homo sapiens
52 MLF2 8079
Co-fractionation Homo sapiens
53 CACYBP 27101
Co-fractionation Homo sapiens
54 NMNAT2  
Affinity Capture-MS Homo sapiens
55 NEURL4  
Affinity Capture-MS Homo sapiens
56 BIRC2  
Affinity Capture-Western Homo sapiens
57 LAT 27040
Affinity Capture-MS Homo sapiens
58 DCTN3 11258
Affinity Capture-MS Homo sapiens
59 USP4 7375
Affinity Capture-Western Homo sapiens
60 CUL3 8452
Affinity Capture-MS Homo sapiens
61 DOCK7 85440
Affinity Capture-MS Homo sapiens
62 CD2BP2 10421
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
63 HMOX2 3163
Affinity Capture-MS Homo sapiens
64 DDX60 55601
Affinity Capture-MS Homo sapiens
65 TRA  
Affinity Capture-Western Homo sapiens
66 SKP2  
Affinity Capture-MS Homo sapiens
67 CSE1L 1434
Affinity Capture-MS Homo sapiens
68 FKBP8 23770
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 NXNL2  
Affinity Capture-MS Homo sapiens
70 ACADSB 36
Affinity Capture-MS Homo sapiens
71 SAAL1 113174
Affinity Capture-MS Homo sapiens
72 SOHLH1  
Affinity Capture-MS Homo sapiens
73 RPAP3 79657
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
74 HSPA4 3308
Affinity Capture-Western Homo sapiens
75 SF3B3 23450
Affinity Capture-MS Homo sapiens
76 LAMP2 3920
Affinity Capture-Western Homo sapiens
77 CAMK2G 818
Affinity Capture-MS Homo sapiens
78 IRF3 3661
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 HIF1A 3091
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
80 STUB1 10273
Affinity Capture-Western Homo sapiens
81 MRPL42  
Affinity Capture-MS Homo sapiens
82 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
83 FASN 2194
Negative Genetic Homo sapiens
84 NSUN5P1  
Affinity Capture-MS Homo sapiens
85 DOCK5 80005
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 PYGL 5836
Affinity Capture-MS Homo sapiens
87 SUCLG2 8801
Affinity Capture-MS Homo sapiens
88 APEX1 328
Affinity Capture-RNA Homo sapiens
89 CDC37 11140
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
90 AURKC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 CCDC117  
Affinity Capture-MS Homo sapiens
92 SQSTM1 8878
Affinity Capture-Western Homo sapiens
93 G3BP1 10146
Affinity Capture-MS Homo sapiens
94 DMWD  
Affinity Capture-MS Homo sapiens
95 FKBP4 2288
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
96 HDAC1 3065
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
97 G3BP2 9908
Affinity Capture-MS Homo sapiens
98 MAT2B 27430
Co-fractionation Homo sapiens
99 DDX58 23586
Affinity Capture-RNA Homo sapiens
100 CDK1 983
Affinity Capture-MS Homo sapiens
101 TBK1 29110
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
102 FERD3L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 BECN1 8678
Affinity Capture-Western Homo sapiens
104 ME1 4199
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
105 CDC37L1  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
106 SERBP1 26135
Affinity Capture-MS Homo sapiens
107 CFTR 1080
Affinity Capture-Western Homo sapiens
108 DERL1 79139
Affinity Capture-Western Homo sapiens
109 MGMT 4255
Affinity Capture-MS Homo sapiens
110 SEC61A1 29927
Affinity Capture-MS Homo sapiens
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