Gene description for BECN1
Gene name beclin 1, autophagy related
Gene symbol BECN1
Other names/aliases ATG6
VPS30
beclin1
Species Homo sapiens
 Database cross references - BECN1
ExoCarta ExoCarta_8678
Vesiclepedia VP_8678
Entrez Gene 8678
HGNC 1034
MIM 604378
UniProt Q14457  
 BECN1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for BECN1
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol 3-kinase binding GO:0043548 IPI
Biological Process
    cellular response to glucose starvation GO:0042149 ISS
    negative regulation of cell proliferation GO:0008285 IEA
    viral process GO:0016032 IEA
    negative regulation of apoptotic process GO:0043066 TAS
    beta-amyloid metabolic process GO:0050435 IEA
    defense response to virus GO:0051607 IEA
    cellular response to nitrogen starvation GO:0006995 IBA
    positive regulation of mitochondrion degradation GO:1903599 IMP
    neuron development GO:0048666 IEA
    positive regulation of attachment of mitotic spindle microtubules to kinetochore GO:1902425 IMP
    macroautophagy GO:0016236 ISS
    response to vitamin E GO:0033197 IEA
    CVT pathway GO:0032258 IBA
    regulation of catalytic activity GO:0050790 IEA
    response to drug GO:0042493 IEA
    receptor catabolic process GO:0032801 IMP
    cellular defense response GO:0006968 TAS
    positive regulation of autophagy GO:0010508 IMP
    autophagosome assembly GO:0000045 ISS
    cytokinesis GO:0000910 IMP
    cellular response to epidermal growth factor stimulus GO:0071364 IEA
    late endosome to vacuole transport GO:0045324 IBA
    lysosome organization GO:0007040 IEA
    cellular response to aluminum ion GO:0071275 IEA
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP
    autophagy GO:0006914 IMP
    response to hypoxia GO:0001666 IEA
    mitotic metaphase plate congression GO:0007080 IMP
    nucleophagy GO:0044804 IBA
    positive regulation of macroautophagy GO:0016239 IEA
    regulation of cytokinesis GO:0032465 IMP
Subcellular Localization
    phosphatidylinositol 3-kinase complex, class III, type I GO:0034271 IBA
    phagocytic vesicle GO:0045335 IEA
    mitochondrial membrane GO:0031966 IEA
    pre-autophagosomal structure GO:0000407 IBA
    dendrite GO:0030425 IEA
    endosome GO:0005768 IDA
    cytoplasmic membrane-bounded vesicle GO:0016023 IBA
    endoplasmic reticulum membrane GO:0005789 IEA
    phosphatidylinositol 3-kinase complex, class III, type II GO:0034272 IBA
    phosphatidylinositol 3-kinase complex, class III GO:0035032 ISS
    endoplasmic reticulum GO:0005783 IDA
    extrinsic component of membrane GO:0019898 IDA
    trans-Golgi network GO:0005802 IEA
    endosome membrane GO:0010008 IEA
    nucleus GO:0005634 IEA
    mitochondrion GO:0005739 IMP
 Experiment description of studies that identified BECN1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BECN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BCL2  
Two-hybrid Homo sapiens
FRET Homo sapiens
2 GOPC 57120
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 BCL2L1 598
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which BECN1 is involved
No pathways found





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