Gene description for CASP3
Gene name	caspase 3, apoptosis-related cysteine peptidase
Gene symbol	CASP3
Other names/aliases	CPP32 CPP32B SCA-1
Species	Homo sapiens
Database cross references - CASP3
ExoCarta	ExoCarta_836
Entrez Gene	836
HGNC	1504
MIM	600636
UniProt	P42574
CASP3 identified in exosomes derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113
Thymus	23844026

Gene ontology annotations for CASP3

Molecular Function     cysteine-type endopeptidase activity GO:0004197 TAS     peptidase activity GO:0008233 IDA     cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 IMP     protein binding GO:0005515 IPI     cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 IEA     cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 IMP     aspartic-type endopeptidase activity GO:0004190 EXP Biological Process     cellular response to DNA damage stimulus GO:0006974 IEA     heart development GO:0007507 IEA     extracellular matrix disassembly GO:0022617 TAS     regulation of apoptotic DNA fragmentation GO:1902510 IEA     release of cytochrome c from mitochondria GO:0001836 IEA     erythrocyte differentiation GO:0030218 TAS     T cell homeostasis GO:0043029 IEA     neuron apoptotic process GO:0051402 IEA     intrinsic apoptotic signaling pathway GO:0097193 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     apoptotic DNA fragmentation GO:0006309 TAS     cell fate commitment GO:0045165 IEA     apoptotic process GO:0006915 TAS     response to wounding GO:0009611 IEA     execution phase of apoptosis GO:0097194 IMP     platelet formation GO:0030220 TAS     proteolysis GO:0006508 IDA     response to UV GO:0009411 IEA     activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 TAS     hippo signaling GO:0035329 TAS     response to tumor necrosis factor GO:0034612 TAS     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IEA     extrinsic apoptotic signaling pathway GO:0097191 TAS     negative regulation of activated T cell proliferation GO:0046007 IEA     keratinocyte differentiation GO:0030216 IBA     neuron differentiation GO:0030182 IBA     regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 TAS     sensory perception of sound GO:0007605 IEA     negative regulation of apoptotic process GO:0043066 IGI     extracellular matrix organization GO:0030198 TAS     glial cell apoptotic process GO:0034349 IEA     apoptotic signaling pathway GO:0097190 TAS     B cell homeostasis GO:0001782 IEA     programmed cell death GO:0012501 TAS     negative regulation of B cell proliferation GO:0030889 IEA     intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 IEA     cellular component disassembly involved in execution phase of apoptosis GO:0006921 TAS     negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 IEA     positive regulation of neuron apoptotic process GO:0043525 IEA     extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 TAS Subcellular Localization     plasma membrane GO:0005886 TAS     cytoplasm GO:0005737 IBA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 TAS     cytosol GO:0005829 TAS