Gene description for LCMT1
Gene name leucine carboxyl methyltransferase 1
Gene symbol LCMT1
Other names/aliases CGI-68
Species Homo sapiens
 Database cross references - LCMT1
ExoCarta ExoCarta_51451
Entrez Gene 51451
HGNC 17557
MIM 610286
UniProt Q9UIC8  
 LCMT1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for LCMT1
Molecular Function
    S-adenosylmethionine-dependent methyltransferase activity GO:0008757 TAS
    protein binding GO:0005515 IPI
    protein C-terminal carboxyl O-methyltransferase activity GO:0003880 IDA
Biological Process
    protein methylation GO:0006479 IMP
    regulation of glucose metabolic process GO:0010906 IEA
    regulation of apoptotic process GO:0042981 IMP
    C-terminal protein methylation GO:0006481 IDA
    regulation of mitotic cell cycle spindle assembly checkpoint GO:0090266 IMP
    negative regulation of protein complex assembly GO:0031333 IMP
    cellular protein modification process GO:0006464 TAS
Subcellular Localization
    cytosol GO:0005829 IEA
 Experiment description of studies that identified LCMT1 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LCMT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FXR2 9513
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which LCMT1 is involved
No pathways found

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