Gene description for FXR2
Gene name fragile X mental retardation, autosomal homolog 2
Gene symbol FXR2
Other names/aliases FMR1L2
FXR2P
Species Homo sapiens
 Database cross references - FXR2
ExoCarta ExoCarta_9513
Vesiclepedia VP_9513
Entrez Gene 9513
HGNC 4024
MIM 605339
UniProt P51116  
 FXR2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for FXR2
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    RNA binding GO:0003723 TAS
    poly(A) RNA binding GO:0044822 IDA
    mRNA binding GO:0003729 IBA
Biological Process
    negative regulation of translation GO:0017148 IBA
    positive regulation of defense response to virus by host GO:0002230 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    polysome GO:0005844 IBA
    extracellular exosome GO:0070062 IDA
    cytosolic large ribosomal subunit GO:0022625 TAS
    membrane GO:0016020 IDA
    nucleus GO:0005634 IBA
 Experiment description of studies that identified FXR2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70|FLOT1
EV Enriched markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70|FLOT1
EV Enriched markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ EV Biophysical techniques
✔
TSG101|HSP70|FLOT1
EV Enriched markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FXR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CBS 875
Two-hybrid Homo sapiens
2 MCRS1  
Two-hybrid Homo sapiens
3 RALYL 138046
Two-hybrid Homo sapiens
4 HNRNPC 3183
Two-hybrid Homo sapiens
5 C10orf62  
Two-hybrid Homo sapiens
6 TRAF2 7186
Two-hybrid Homo sapiens
7 NDP52  
Two-hybrid Homo sapiens
8 RBPMS 11030
Two-hybrid Homo sapiens
9 SNAP23 8773
Two-hybrid Homo sapiens
10 KCNRG  
Two-hybrid Homo sapiens
11 EFCBP2  
Two-hybrid Homo sapiens
12 RTN3 10313
Two-hybrid Homo sapiens
13 PSME3 10197
Two-hybrid Homo sapiens
14 RBMX 27316
Two-hybrid Homo sapiens
15 FMR1 2332
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
16 CRSP9  
Affinity Capture-MS Homo sapiens
17 KIAA1217 56243
Two-hybrid Homo sapiens
18 MBIP  
Two-hybrid Homo sapiens
19 PAICS 10606
Two-hybrid Homo sapiens
20 AP1M1 8907
Two-hybrid Homo sapiens
21 KCTD4  
Two-hybrid Homo sapiens
22 KXD1 79036
Two-hybrid Homo sapiens
23 ZBTB8  
Two-hybrid Homo sapiens
24 ARL6IP1 23204
Two-hybrid Homo sapiens
25 FTH1 2495
Two-hybrid Homo sapiens
26 CYFIP2 26999
Affinity Capture-MS Homo sapiens
27 CCDC33 80125
Two-hybrid Homo sapiens
28 NONO 4841
Two-hybrid Homo sapiens
29 NCK2 8440
Two-hybrid Homo sapiens
30 THAP1  
Two-hybrid Homo sapiens
31 AP2M1 1173
Two-hybrid Homo sapiens
32 NT5C2 22978
Two-hybrid Homo sapiens
33 DIPA  
Two-hybrid Homo sapiens
34 DPPA2  
Two-hybrid Homo sapiens
35 TRIM37  
Two-hybrid Homo sapiens
36 FXR1 8087
Invivo Homo sapiens
Invitro Homo sapiens
Co-purification Homo sapiens
37 TSC22D4 81628
Two-hybrid Homo sapiens
38 LCMT1 51451
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
39 RABAC1 10567
Two-hybrid Homo sapiens
40 AMOTL2 51421
Two-hybrid Homo sapiens
41 FXR2 9513
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
42 FBP1 2203
Two-hybrid Homo sapiens
43 SSSCA1 10534
Two-hybrid Homo sapiens
44 FLJ11730  
Two-hybrid Homo sapiens
45 PCBD1 5092
Two-hybrid Homo sapiens
46 LDOC1  
Two-hybrid Homo sapiens
47 GKAP1  
Two-hybrid Homo sapiens
48 KRT20 54474
Two-hybrid Homo sapiens
49 CYFIP1 23191
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
50 TRIM29 23650
Two-hybrid Homo sapiens
51 ZNF451 26036
Two-hybrid Homo sapiens
52 RTN4 57142
Two-hybrid Homo sapiens
53 RPIA 22934
Two-hybrid Homo sapiens
54 RBBP8  
Two-hybrid Homo sapiens
55 TNNT1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which FXR2 is involved
No pathways found





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