Gene description for FXR2
Gene name fragile X mental retardation, autosomal homolog 2
Gene symbol FXR2
Other names/aliases FMR1L2
FXR2P
Species Homo sapiens
 Database cross references - FXR2
ExoCarta ExoCarta_9513
Vesiclepedia VP_9513
Entrez Gene 9513
HGNC 4024
MIM 605339
UniProt P51116  
 FXR2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for FXR2
Molecular Function
    RNA binding GO:0003723 HDA
    mRNA 3'-UTR binding GO:0003730 IBA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
    translation regulator activity GO:0045182 IBA
    protein heterodimerization activity GO:0046982 IDA
Biological Process
    dentate gyrus development GO:0021542 ISS
    regulation of mRNA stability GO:0043488 IBA
    positive regulation of translation GO:0045727 IBA
    positive regulation of long-term neuronal synaptic plasticity GO:0048170 IBA
    animal organ development GO:0048513 IBA
    mRNA transport GO:0051028 IBA
    mRNA destabilization GO:0061157 ISS
    regulation of translation at presynapse, modulating synaptic transmission GO:0099577 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytoplasmic stress granule GO:0010494 IBA
    cytoplasmic stress granule GO:0010494 IDA
    membrane GO:0016020 HDA
    neuron projection GO:0043005 IBA
    presynapse GO:0098793 IEA
    postsynapse GO:0098794 IEA
 Experiment description of studies that identified FXR2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FXR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CBS 875
Two-hybrid Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 Mtx1  
Affinity Capture-MS Mus musculus
4 RALYL 138046
Two-hybrid Homo sapiens
5 HNRNPC 3183
Two-hybrid Homo sapiens
6 LDOC1  
Two-hybrid Homo sapiens
7 NECAB2  
Two-hybrid Homo sapiens
8 SPRTN  
Affinity Capture-MS Homo sapiens
9 RBPMS 11030
Two-hybrid Homo sapiens
10 COIL  
Two-hybrid Homo sapiens
11 KCTD4  
Two-hybrid Homo sapiens
12 SNAP23 8773
Two-hybrid Homo sapiens
13 ZBTB22  
Two-hybrid Homo sapiens
14 KCNRG  
Two-hybrid Homo sapiens
15 SNX1 6642
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 BAZ2B  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
17 PPIE 10450
Affinity Capture-MS Homo sapiens
18 SRPK2 6733
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
19 FMR1 2332
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 CCR4 1233
Two-hybrid Homo sapiens
21 DDX17 10521
Two-hybrid Homo sapiens
22 USP39 10713
Two-hybrid Homo sapiens
23 BRCA1 672
Two-hybrid Homo sapiens
24 BYSL 705
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
25 PRKAA1 5562
Affinity Capture-MS Homo sapiens
26 GKAP1  
Two-hybrid Homo sapiens
27 CAND1 55832
Affinity Capture-MS Homo sapiens
28 ARL6IP1 23204
Two-hybrid Homo sapiens
29 LCMT1 51451
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
30 RTN4 57142
Two-hybrid Homo sapiens
31 GSK3A 2931
Affinity Capture-MS Homo sapiens
32 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 PCBD1 5092
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
34 KIF20A 10112
Affinity Capture-MS Homo sapiens
35 TOP2A 7153
Affinity Capture-MS Homo sapiens
36 RPS20 6224
Proximity Label-MS Homo sapiens
37 MBIP  
Two-hybrid Homo sapiens
38 ZBTB3  
Affinity Capture-MS Homo sapiens
39 TSC22D4 81628
Two-hybrid Homo sapiens
40 MEAF6  
Two-hybrid Homo sapiens
41 SYT6  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
42 LASP1 3927
Two-hybrid Homo sapiens
43 RABAC1 10567
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
44 TGFB1 7040
Affinity Capture-MS Homo sapiens
45 KIF23 9493
Affinity Capture-MS Homo sapiens
46 TSNAX 7257
Affinity Capture-MS Homo sapiens
47 Zbtb48  
Affinity Capture-MS Mus musculus
48 YES1 7525
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
49 MORF4L1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
50 PRC1 9055
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
51 CPSF7 79869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 NPM1 4869
Affinity Capture-MS Homo sapiens
53 FBL 2091
Proximity Label-MS Homo sapiens
54 CALCOCO2  
Two-hybrid Homo sapiens
55 OBSL1 23363
Affinity Capture-MS Homo sapiens
56 EWSR1 2130
Two-hybrid Homo sapiens
57 ZNF451 26036
Two-hybrid Homo sapiens
58 DCTD 1635
Affinity Capture-MS Homo sapiens
59 RPIA 22934
Two-hybrid Homo sapiens
60 RC3H1 149041
Affinity Capture-MS Homo sapiens
61 SRP68 6730
Affinity Capture-MS Homo sapiens
62 YWHAH 7533
Affinity Capture-MS Homo sapiens
63 RRP8  
Affinity Capture-MS Homo sapiens
64 IGFN1  
Two-hybrid Homo sapiens
65 Fxr1 14359
Two-hybrid Mus musculus
66 GTSE1 51512
Two-hybrid Homo sapiens
67 SYTL4 94121
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
68 MECP2 4204
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 MYCN  
Affinity Capture-MS Homo sapiens
70 RBM42  
Affinity Capture-MS Homo sapiens
71 NIF3L1 60491
Two-hybrid Homo sapiens
72 RBM14 10432
Two-hybrid Homo sapiens
73 DYNLT1 6993
Two-hybrid Homo sapiens
74 KIF14 9928
Affinity Capture-MS Homo sapiens
75 DMRTB1  
Two-hybrid Homo sapiens
76 PSME3 10197
Two-hybrid Homo sapiens
77 RBMX 27316
Two-hybrid Homo sapiens
78 AMOTL2 51421
Two-hybrid Homo sapiens
79 KIAA1217 56243
Two-hybrid Homo sapiens
80 PRPF6 24148
Two-hybrid Homo sapiens
81 MED7  
Affinity Capture-MS Homo sapiens
82 EIF4G1 1981
Two-hybrid Homo sapiens
83 CEP55 55165
Two-hybrid Homo sapiens
84 SCEL 8796
Two-hybrid Homo sapiens
85 CDKL3  
Two-hybrid Homo sapiens
86 PARK2  
Affinity Capture-MS Homo sapiens
87 CCDC33 80125
Two-hybrid Homo sapiens
88 NONO 4841
Two-hybrid Homo sapiens
89 UBAP2L 9898
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
90 DPPA2  
Two-hybrid Homo sapiens
91 ZCCHC17  
Affinity Capture-MS Homo sapiens
92 CHMP4B 128866
Affinity Capture-MS Homo sapiens
93 BTF3 689
Affinity Capture-MS Homo sapiens
94 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 NTRK1 4914
Affinity Capture-MS Homo sapiens
96 CECR2  
Affinity Capture-MS Homo sapiens
97 IFI16 3428
Affinity Capture-MS Homo sapiens
98 MIA3 375056
Two-hybrid Homo sapiens
99 CBX6  
Affinity Capture-MS Homo sapiens
100 BICD2 23299
Proximity Label-MS Homo sapiens
101 RPA4  
Proximity Label-MS Homo sapiens
102 HECTD1 25831
Affinity Capture-MS Homo sapiens
103 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 RPLP0 6175
Affinity Capture-MS Homo sapiens
105 RPS16 6217
Affinity Capture-MS Homo sapiens
106 PAICS 10606
Two-hybrid Homo sapiens
107 ANLN 54443
Affinity Capture-MS Homo sapiens
108 ZBTB2 57621
Affinity Capture-MS Homo sapiens
109 MAP7 9053
Affinity Capture-MS Homo sapiens
110 RPS2 6187
Two-hybrid Homo sapiens
111 TBKBP1  
Affinity Capture-MS Homo sapiens
112 RC3H2  
Affinity Capture-MS Homo sapiens
113 ECT2 1894
Affinity Capture-MS Homo sapiens
114 SIRT7  
Affinity Capture-MS Homo sapiens
115 PITHD1 57095
Affinity Capture-MS Homo sapiens
116 TBC1D22B  
Two-hybrid Homo sapiens
117 AKAP9 10142
Two-hybrid Homo sapiens
118 ZSCAN1  
Two-hybrid Homo sapiens
119 CD6 923
Affinity Capture-MS Homo sapiens
120 AP1M1 8907
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
121 CUL3 8452
Affinity Capture-MS Homo sapiens
122 NR3C1 2908
Proximity Label-MS Homo sapiens
123 POM121  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
124 INPP5J  
Two-hybrid Homo sapiens
125 FAM90A1  
Two-hybrid Homo sapiens
126 TDRD3  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
127 HMBOX1  
Two-hybrid Homo sapiens
128 FTH1 2495
Two-hybrid Homo sapiens
129 MYC  
Affinity Capture-MS Homo sapiens
130 NEXN 91624
Two-hybrid Homo sapiens
131 SUZ12  
Affinity Capture-MS Homo sapiens
132 C10orf62  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
133 THAP1  
Two-hybrid Homo sapiens
134 AP2M1 1173
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
135 BLK 640
Two-hybrid Homo sapiens
136 NT5C2 22978
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
137 MAPRE3  
Two-hybrid Homo sapiens
138 SLAIN2  
Affinity Capture-MS Homo sapiens
139 PCBP1 5093
Affinity Capture-MS Homo sapiens
140 MFAP1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
141 PSPC1 55269
Affinity Capture-MS Homo sapiens
142 RPA3 6119
Proximity Label-MS Homo sapiens
143 FXR2 9513
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
144 CCDC85B  
Two-hybrid Homo sapiens
145 Tubg1 103733
Affinity Capture-MS Mus musculus
146 SIRT6  
Affinity Capture-MS Homo sapiens
147 NUP214 8021
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 NUDT21 11051
Affinity Capture-MS Homo sapiens
149 DDRGK1 65992
Affinity Capture-MS Homo sapiens
150 RNF2  
Affinity Capture-MS Homo sapiens
151 BMI1  
Affinity Capture-MS Homo sapiens
152 PCM1 5108
Two-hybrid Homo sapiens
153 P4HA3 283208
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
154 BMP4 652
Affinity Capture-MS Homo sapiens
155 GNB2L1 10399
Affinity Capture-MS Homo sapiens
156 RBBP8  
Two-hybrid Homo sapiens
157 TNNT1  
Two-hybrid Homo sapiens
158 SNCA 6622
Affinity Capture-MS Homo sapiens
159 KIF2A 3796
Two-hybrid Homo sapiens
160 KIF1A 547
Two-hybrid Homo sapiens
161 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
162 TERF2  
Affinity Capture-MS Homo sapiens
163 TRAF2 7186
Two-hybrid Homo sapiens
164 Haus4  
Affinity Capture-MS Mus musculus
165 ILF3 3609
Affinity Capture-MS Homo sapiens
166 WDR77 79084
Affinity Capture-MS Homo sapiens
167 CPSF6 11052
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
168 THUMPD3 25917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 RTN3 10313
Two-hybrid Homo sapiens
170 ZMAT2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
171 ZBTB8A  
Two-hybrid Homo sapiens
172 FXR1 8087
Co-purification Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
173 LSM14A 26065
Affinity Capture-MS Homo sapiens
174 MRPL43 84545
Two-hybrid Homo sapiens
175 ZNF232  
Two-hybrid Homo sapiens
176 PIM1  
Two-hybrid Homo sapiens
177 G3BP1 10146
Affinity Capture-MS Homo sapiens
178 C1orf35  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
179 CAPRIN1 4076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
180 G3BP2 9908
Affinity Capture-MS Homo sapiens
181 CWF19L2  
Two-hybrid Homo sapiens
182 DDX58 23586
Affinity Capture-RNA Homo sapiens
183 MKI67  
Affinity Capture-MS Homo sapiens
184 PRAM1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
185 NCK2 8440
Two-hybrid Homo sapiens
186 CEP44  
Two-hybrid Homo sapiens
187 UFL1 23376
Affinity Capture-MS Homo sapiens
188 TBK1 29110
Affinity Capture-MS Homo sapiens
189 TRIM37  
Two-hybrid Homo sapiens
190 OTUD4  
Affinity Capture-MS Homo sapiens
191 BTBD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
192 MCRS1  
Two-hybrid Homo sapiens
Two-hybrid