Gene description for CCR4
Gene name chemokine (C-C motif) receptor 4
Gene symbol CCR4
Other names/aliases CC-CKR-4
CD194
CKR4
CMKBR4
ChemR13
HGCN:14099
K5-5
Species Homo sapiens
 Database cross references - CCR4
ExoCarta ExoCarta_1233
Entrez Gene 1233
HGNC 1605
MIM 604836
UniProt P51679  
 CCR4 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CCR4
Molecular Function
    chemokine receptor activity GO:0004950 TAS
    C-C chemokine receptor activity GO:0016493 IEA
Biological Process
    inflammatory response GO:0006954 IEA
    neuron migration GO:0001764 IEA
    response to antibiotic GO:0046677 IEA
    response to radiation GO:0009314 IEA
    positive regulation of cytosolic calcium ion concentration GO:0007204 TAS
    immune response GO:0006955 IEA
    positive regulation of positive chemotaxis GO:0050927 IEA
    response to bacterium GO:0009617 IEA
    chemokine-mediated signaling pathway GO:0070098 TAS
    G-protein coupled receptor signaling pathway GO:0007186 IEA
    chemotaxis GO:0006935 IEA
    tolerance induction GO:0002507 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    neuronal cell body GO:0043025 IEA
    external side of plasma membrane GO:0009897 IEA
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 TAS
 Experiment description of studies that identified CCR4 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CCR4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ADRBK1 156
Affinity Capture-Western Homo sapiens
2 CCL3  
Invitro Homo sapiens
3 CCL22 6367
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
4 CCL17  
Invivo Homo sapiens
Invitro Homo sapiens
5 ADRBK2  
Affinity Capture-Western Homo sapiens
6 CCL5  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which CCR4 is involved
PathwayEvidenceSource
Chemokine receptors bind chemokines TAS Reactome
G alpha (i) signalling events TAS Reactome





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