Gene description for CNTNAP1
Gene name contactin associated protein 1
Gene symbol CNTNAP1
Other names/aliases CASPR
CNTNAP
NRXN4
P190
Species Homo sapiens
 Database cross references - CNTNAP1
ExoCarta ExoCarta_8506
Vesiclepedia VP_8506
Entrez Gene 8506
HGNC 8011
MIM 602346
UniProt P78357  
 CNTNAP1 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CNTNAP1
Molecular Function
    protein binding GO:0005515 IPI
    SH3 domain binding GO:0017124 ISS
    signaling receptor activity GO:0038023 TAS
Biological Process
    protein localization to paranode region of axon GO:0002175 ISS
    mitochondrion organization GO:0007005 IEA
    cytoskeleton organization GO:0007010 ISS
    cell adhesion GO:0007155 IEA
    signal transduction GO:0007165 TAS
    axonogenesis GO:0007409 IEA
    neuronal action potential propagation GO:0019227 ISS
    central nervous system myelination GO:0022010 IMP
    myelination in peripheral nervous system GO:0022011 IMP
    paranodal junction assembly GO:0030913 IMP
    paranodal junction assembly GO:0030913 ISS
    neuron projection morphogenesis GO:0048812 IMP
    neuron projection morphogenesis GO:0048812 ISS
    neuromuscular process controlling posture GO:0050884 IEA
    neuromuscular process controlling balance GO:0050885 IEA
    protein localization to juxtaparanode region of axon GO:0071205 ISS
    regulation of synapse maturation GO:0090128 IEA
    postsynaptic density organization GO:0097106 IEA
    neuromuscular junction development, skeletal muscle fiber GO:0098529 IEA
    paranodal junction maintenance GO:1990227 IEA
Subcellular Localization
    membrane GO:0016020 IEA
    paranodal junction GO:0033010 IEA
    paranode region of axon GO:0033270 ISS
    presynaptic active zone GO:0048786 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified CNTNAP1 in exosomes
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CNTNAP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 CCL3  
Affinity Capture-MS Homo sapiens
3 C7orf34  
Affinity Capture-MS Homo sapiens
4 KCNA1  
Affinity Capture-Western Homo sapiens
5 BTNL2  
Affinity Capture-MS Homo sapiens
6 TMEM106A  
Affinity Capture-MS Homo sapiens
7 KCNA2  
Affinity Capture-Western Homo sapiens
8 CLGN 1047
Affinity Capture-MS Homo sapiens
9 CANX 821
Affinity Capture-MS Homo sapiens
10 NDP  
Affinity Capture-MS Homo sapiens
11 LDLRAD1  
Affinity Capture-MS Homo sapiens
12 SDF2 6388
Affinity Capture-MS Homo sapiens
13 CCR4 1233
Two-hybrid Homo sapiens
14 HAVCR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 FAM19A4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 LMAN2L 81562
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 SIL1 64374
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SEMA4A  
Affinity Capture-MS Homo sapiens
19 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 KLRG2 346689
Affinity Capture-MS Homo sapiens
21 SLURP1  
Affinity Capture-MS Homo sapiens
22 NCR3  
Affinity Capture-MS Homo sapiens
23 RTN4 57142
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 INSL5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SYCN  
Affinity Capture-MS Homo sapiens
26 SFTPC  
Affinity Capture-MS Homo sapiens
27 SDF2L1 23753
Affinity Capture-MS Homo sapiens
28 FBXO2 26232
Affinity Capture-MS Homo sapiens
29 C1orf54  
Affinity Capture-MS Homo sapiens
30 CLEC4M  
Affinity Capture-MS Homo sapiens
31 CRP  
Affinity Capture-MS Homo sapiens
32 GLIPR1L2  
Affinity Capture-MS Homo sapiens
33 EVA1B 55194
Affinity Capture-MS Homo sapiens
34 EDN3  
Affinity Capture-MS Homo sapiens
35 NXPH3  
Affinity Capture-MS Homo sapiens
36 CHST8 64377
Affinity Capture-MS Homo sapiens
37 FAM19A2 338811
Affinity Capture-MS Homo sapiens
38 S1PR4  
Affinity Capture-MS Homo sapiens
39 CFC1  
Affinity Capture-MS Homo sapiens
40 SPINT2 10653
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 EDDM3B  
Affinity Capture-MS Homo sapiens
42 CD93  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 IGFL3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here