Gene description for SIL1
Gene name SIL1 nucleotide exchange factor
Gene symbol SIL1
Other names/aliases BAP
MSS
ULG5
Species Homo sapiens
 Database cross references - SIL1
ExoCarta ExoCarta_64374
Vesiclepedia VP_64374
Entrez Gene 64374
HGNC 24624
MIM 608005
UniProt Q9H173  
 SIL1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SIL1
Molecular Function
    adenyl-nucleotide exchange factor activity GO:0000774 IBA
    adenyl-nucleotide exchange factor activity GO:0000774 IDA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    unfolded protein binding GO:0051082 NAS
Biological Process
    protein folding GO:0006457 NAS
    cotranslational protein targeting to membrane GO:0006613 ISS
    intracellular protein transport GO:0006886 NAS
Subcellular Localization
    extracellular space GO:0005615 HDA
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum GO:0005783 NAS
    endoplasmic reticulum lumen GO:0005788 IEA
 Experiment description of studies that identified SIL1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SIL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBR2 23304
Affinity Capture-MS Homo sapiens
2 COL14A1 7373
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 KNDC1  
Affinity Capture-MS Homo sapiens
4 SGTB  
Two-hybrid Homo sapiens
5 PRTN3 5657
Affinity Capture-MS Homo sapiens
6 FCGR3B  
Affinity Capture-MS Homo sapiens
7 HSPA5 3309
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 NAAA  
Affinity Capture-MS Homo sapiens
9 ADAMTS4  
Affinity Capture-MS Homo sapiens
10 C1QTNF9B  
Affinity Capture-MS Homo sapiens
11 FOXA1  
Affinity Capture-MS Homo sapiens
12 FAM20C 56975
Affinity Capture-MS Homo sapiens
13 LCN6  
Affinity Capture-MS Homo sapiens
14 CALR3  
Proximity Label-MS Homo sapiens
15 IDS  
Affinity Capture-MS Homo sapiens
16 HHIPL1 84439
Affinity Capture-MS Homo sapiens
17 PDIA4 9601
Proximity Label-MS Homo sapiens
18 TMEM25  
Affinity Capture-MS Homo sapiens
19 LRRC59 55379
Proximity Label-MS Homo sapiens
20 PSMD8 5714
Co-fractionation Homo sapiens
21 PON2 5445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 DPEP2  
Affinity Capture-MS Homo sapiens
23 FEM1C  
Protein-peptide Homo sapiens
Protein-peptide Homo sapiens
24 NME2P1 283458
Affinity Capture-MS Homo sapiens
25 MGARP  
Co-fractionation Homo sapiens
26 AGA 175
Affinity Capture-MS Homo sapiens
27 CBLN4  
Affinity Capture-MS Homo sapiens
28 FAM109A  
Affinity Capture-MS Homo sapiens
29 B3GALT4  
Affinity Capture-MS Homo sapiens
30 FBXO6 26270
Affinity Capture-MS Homo sapiens
31 OMA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 WNT10B 7480
Affinity Capture-MS Homo sapiens
33 C1QTNF7  
Affinity Capture-MS Homo sapiens
34 SERPINB11  
Affinity Capture-MS Homo sapiens
35 GLB1L3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 Kat8  
Affinity Capture-MS Mus musculus
37 POC1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 ERGIC2 51290
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 C12orf49  
Positive Genetic Homo sapiens
40 UBR1 197131
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 SIRPD  
Affinity Capture-MS Homo sapiens
42 BRICD5  
Affinity Capture-MS Homo sapiens
43 PDGFRL 5157
Affinity Capture-MS Homo sapiens
44 SMAD9  
Two-hybrid Homo sapiens
45 LCN9  
Affinity Capture-MS Homo sapiens
46 SCGB2A2  
Affinity Capture-MS Homo sapiens
47 C1orf54  
Affinity Capture-MS Homo sapiens
48 CNTNAP1 8506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
50 FIGF 2277
Affinity Capture-MS Homo sapiens
51 CEP192 55125
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 PFDN4 5203
Co-fractionation Homo sapiens
53 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
54 TDGF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 POC1B 282809
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 ST8SIA5  
Affinity Capture-MS Homo sapiens
57 ADAM18  
Affinity Capture-MS Homo sapiens
58 PRELP 5549
Affinity Capture-MS Homo sapiens
59 PTCH1  
Affinity Capture-MS Homo sapiens
60 UBQLN1 29979
Two-hybrid Homo sapiens
61 PTPRO 5800
Affinity Capture-MS Homo sapiens
62 ISLR 3671
Affinity Capture-MS Homo sapiens
63 SEC61B 10952
Proximity Label-MS Homo sapiens
64 EDRF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 CCND3  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SIL1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here