Gene description for HHIPL1
Gene name HHIP-like 1
Gene symbol HHIPL1
Other names/aliases KIAA1822
UNQ9245
Species Homo sapiens
 Database cross references - HHIPL1
ExoCarta ExoCarta_84439
Entrez Gene 84439
HGNC 19710
UniProt Q96JK4  
 HHIPL1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for HHIPL1
Molecular Function
    scavenger receptor activity GO:0005044 IEA
    quinone binding GO:0048038 IEA
    molecular_function GO:0003674 ND
    oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor GO:0016901 IEA
Biological Process
    receptor-mediated endocytosis GO:0006898 IEA
    oxidation-reduction process GO:0055114 IEA
    carbohydrate metabolic process GO:0005975 IEA
    biological_process GO:0008150 ND
Subcellular Localization
    membrane GO:0016020 IEA
    extracellular region GO:0005576 IEA
    cellular_component GO:0005575 ND
 Experiment description of studies that identified HHIPL1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for HHIPL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HHIPL1 is involved
No pathways found





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