Gene description for C8B
Gene name complement component 8, beta polypeptide
Gene symbol C8B
Other names/aliases C82
Species Homo sapiens
 Database cross references - C8B
ExoCarta ExoCarta_732
Vesiclepedia VP_732
Entrez Gene 732
HGNC 1353
MIM 120960
UniProt P07358  
 C8B identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for C8B
Molecular Function
    protein complex binding GO:0032403 IEA
Biological Process
    immune response GO:0006955 TAS
    complement activation, classical pathway GO:0006958 IEA
    cytolysis GO:0019835 IEA
    complement activation GO:0006956 TAS
    innate immune response GO:0045087 TAS
    complement activation, alternative pathway GO:0006957 IEA
    regulation of complement activation GO:0030449 TAS
Subcellular Localization
    extracellular vesicle GO:1903561 IDA
    membrane attack complex GO:0005579 IEA
    extracellular region GO:0005576 TAS
    membrane GO:0016020 TAS
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified C8B in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for C8B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CLU 1191
Reconstituted Complex Homo sapiens
2 C5 727
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which C8B is involved
PathwayEvidenceSource
Regulation of Complement cascade TAS Reactome
Terminal pathway of complement TAS Reactome





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