Gene description for POLRMT
Gene name polymerase (RNA) mitochondrial (DNA directed)
Gene symbol POLRMT
Other names/aliases APOLMT
MTRNAP
MTRPOL
h-mtRPOL
Species Homo sapiens
 Database cross references - POLRMT
ExoCarta ExoCarta_5442
Entrez Gene 5442
HGNC 9200
MIM 601778
UniProt O00411  
 POLRMT identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for POLRMT
Molecular Function
    DNA binding GO:0003677 IEA
    DNA-directed RNA polymerase activity GO:0003899 TAS
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    transcription from mitochondrial promoter GO:0006390 TAS
    gene expression GO:0010467 TAS
    mitochondrion organization GO:0007005 TAS
    transcription initiation from mitochondrial promoter GO:0006391 TAS
    organelle organization GO:0006996 TAS
Subcellular Localization
    mitochondrial matrix GO:0005759 TAS
    mitochondrial nucleoid GO:0042645 IDA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified POLRMT in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for POLRMT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TFB1M  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which POLRMT is involved
PathwayEvidenceSource
Mitochondrial transcription initiation TAS Reactome
Transcriptional activation of mitochondrial biogenesis TAS Reactome





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