ExoCarta: Gene summary

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Gene description for MRPS23
Gene name	mitochondrial ribosomal protein S23
Gene symbol	MRPS23
Other names/aliases	CGI-138 HSPC329 MRP-S23
Species	Homo sapiens
Database cross references - MRPS23
ExoCarta	ExoCarta_51649
Vesiclepedia	VP_51649
Entrez Gene	51649
HGNC	14509
MIM	611985
UniProt	Q9Y3D9
MRPS23 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942

Gene ontology annotations for MRPS23

Molecular Function
	RNA binding	GO:0003723	HDA
	structural constituent of ribosome	GO:0003735	IEA
	protein binding	GO:0005515	IPI
Biological Process
	mitochondrial translation	GO:0032543	NAS
Subcellular Localization
	mitochondrion	GO:0005739	HTP
	mitochondrion	GO:0005739	IBA
	mitochondrion	GO:0005739	IDA
	mitochondrial inner membrane	GO:0005743	NAS
	mitochondrial inner membrane	GO:0005743	TAS
	mitochondrial small ribosomal subunit	GO:0005763	NAS
	nuclear membrane	GO:0031965	IDA

Experiment description of studies that identified MRPS23 in exosomes

Experiment ID

489

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Protein-protein interactions for MRPS23

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

GNL2

29889

Affinity Capture-MS

Homo sapiens

RBM42

Affinity Capture-MS

Homo sapiens

CDC14B

8555

Affinity Capture-MS

Homo sapiens

PDHA1

5160

Proximity Label-MS

Homo sapiens

MRPS27

23107

Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens

CPSF6

11052

Affinity Capture-MS

Homo sapiens

UBE2H

7328

Affinity Capture-MS

Homo sapiens

SLIRP

81892

Proximity Label-MS

Homo sapiens

QARS

5859

Co-fractionation

Homo sapiens

CTPS2

56474

Affinity Capture-MS

Homo sapiens

ZNF324B

Affinity Capture-MS

Homo sapiens

LHX2

Proximity Label-MS

Homo sapiens

TRUB2

Proximity Label-MS

Homo sapiens

MTG2

Proximity Label-MS

Homo sapiens

NGRN

Proximity Label-MS

Homo sapiens

CHCHD1

Proximity Label-MS

Homo sapiens

KLF12

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HSPB1

3315

Two-hybrid

Homo sapiens

CAND1

55832

Affinity Capture-MS

Homo sapiens

RPUSD4

84881

Proximity Label-MS

Homo sapiens

DNAJC15

Proximity Label-MS

Homo sapiens

MTRF1

Proximity Label-MS

Homo sapiens

GFM2

84340

Proximity Label-MS

Homo sapiens

SUPV3L1

6832

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CCDC90B

Proximity Label-MS

Homo sapiens

AMOTL1

154810

Affinity Capture-MS

Homo sapiens

LRPPRC

10128

Proximity Label-MS

Homo sapiens

KIAA1429

25962

Affinity Capture-MS

Homo sapiens

CAPZB

832

Affinity Capture-MS

Homo sapiens

IGF2BP3

10643

Affinity Capture-MS

Homo sapiens

OTC

5009

Proximity Label-MS

Homo sapiens

MCU

90550

Proximity Label-MS

Homo sapiens

CRYZ

1429

Proximity Label-MS

Homo sapiens

TFAM

7019

Proximity Label-MS

Homo sapiens

PMPCA

23203

Proximity Label-MS

Homo sapiens

C8orf82

Proximity Label-MS

Homo sapiens

CYB5R1

51706

Co-fractionation

Homo sapiens

MRPS5

64969

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HINT2

84681

Proximity Label-MS

Homo sapiens

MRPS24

64951

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

NPM1

4869

Affinity Capture-MS

Homo sapiens

SRRM2

23524

Affinity Capture-MS

Homo sapiens

DDRGK1

65992

Affinity Capture-MS

Homo sapiens

KLF15

Affinity Capture-MS

Homo sapiens

ARMC8

25852

Affinity Capture-MS

Homo sapiens

RPS9

6203

Affinity Capture-MS

Homo sapiens

MRPS26

64949

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SURF1

Proximity Label-MS

Homo sapiens

SRSF3

6428

Affinity Capture-MS

Homo sapiens

DYNLL1

8655

Affinity Capture-MS

Homo sapiens

EXD2

Proximity Label-MS

Homo sapiens

TULP3

7289

Affinity Capture-MS

Homo sapiens

ITGA4

3676

Affinity Capture-MS

Homo sapiens

KLF4

Affinity Capture-MS

Homo sapiens

VCAM1

7412

Affinity Capture-MS

Homo sapiens

CEP57

Affinity Capture-MS

Homo sapiens

MRPS7

51081

Affinity Capture-MS

Homo sapiens

MECP2

4204

Affinity Capture-MS

Homo sapiens

TLX3

Proximity Label-MS

Homo sapiens

CUL1

8454

Affinity Capture-MS

Homo sapiens

KLF16

Affinity Capture-MS

Homo sapiens

PMPCB

9512

Proximity Label-MS

Homo sapiens

TACO1

Proximity Label-MS

Homo sapiens

FASTKD2

Proximity Label-MS

Homo sapiens

MTIF2

4528

Proximity Label-MS

Homo sapiens

AMOT

Affinity Capture-MS

Homo sapiens

ARHGEF15

Affinity Capture-MS

Homo sapiens

FAM120A

23196

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MTERF3

Proximity Label-MS

Homo sapiens

HSPA8

3312

Co-fractionation

Homo sapiens

MDH2

4191

Proximity Label-MS

Homo sapiens

TFB1M

Affinity Capture-MS

Homo sapiens

SOX6

Affinity Capture-MS

Homo sapiens

MRPS25

64432

Affinity Capture-MS

Homo sapiens

CDKN2AIP

Affinity Capture-MS

Homo sapiens

POLD1

5424

Affinity Capture-MS

Homo sapiens

C6orf203

Proximity Label-MS

Homo sapiens

ZNF133

Affinity Capture-MS

Homo sapiens

COX15

1355

Proximity Label-MS

Homo sapiens

FASTKD5

Proximity Label-MS

Homo sapiens

RPL26

6154

Affinity Capture-MS

Homo sapiens

PARK2

Affinity Capture-MS

Homo sapiens

MRPS34

65993

Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

ERBB3

2065

Affinity Capture-MS

Homo sapiens

ZBTB47

Affinity Capture-MS

Homo sapiens

SNRPA

6626

Affinity Capture-MS

Homo sapiens

TRA2A

29896

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

POLRMT

5442

Affinity Capture-MS

Homo sapiens

TUBGCP4

27229

Affinity Capture-MS

Homo sapiens

TUFM

7284

Proximity Label-MS

Homo sapiens

TPD52

7163

Affinity Capture-MS

Homo sapiens

PTCD3

55037

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HSCB

150274

Proximity Label-MS

Homo sapiens

VCP

7415

Affinity Capture-MS

Homo sapiens

COPS5

10987

Affinity Capture-MS

Homo sapiens

MRPS6

Affinity Capture-MS

Homo sapiens

CCDC109B

55013

Proximity Label-MS

Homo sapiens

RAD18

Affinity Capture-MS

Homo sapiens

DNAJA1

3301

Co-fractionation

Homo sapiens

100

MOV10

4343

Affinity Capture-RNA

Homo sapiens

101

NOA1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

102

MTFMT

Proximity Label-MS

Homo sapiens

103

ZFC3H1

196441

Affinity Capture-MS

Homo sapiens

104

CEP76

Affinity Capture-MS

Homo sapiens

105

AGPS

8540

Co-fractionation

Homo sapiens

106

HSD17B8

Affinity Capture-MS

Homo sapiens

107

MRPS33

Affinity Capture-MS

Homo sapiens

108

NPM3

10360

Affinity Capture-MS

Homo sapiens

109

HIST1H1E

3008

Co-fractionation

Homo sapiens

110

ATG16L1

55054

Affinity Capture-MS

Homo sapiens

111

TLX2

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

112

YBX3

8531

Affinity Capture-MS

Homo sapiens

113

E4F1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

114

RBM39

9584

Affinity Capture-MS

Homo sapiens

115

DNAJC21

Affinity Capture-MS

Homo sapiens

116

MRRF

Proximity Label-MS

Homo sapiens

117

ABT1

29777

Affinity Capture-MS

Homo sapiens

118

MRPS12

Proximity Label-MS

Homo sapiens

119

SRSF7

6432

Affinity Capture-MS

Homo sapiens

120

DAP3

7818

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

121

TLX1

Affinity Capture-MS

Homo sapiens

122

MRPS35

60488

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

123

RC3H2

Affinity Capture-MS

Homo sapiens

124

MRPS11

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

125

MTIF3

Proximity Label-MS

Homo sapiens

126

RPL35

11224

Affinity Capture-MS

Homo sapiens

127

MRPS14

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

128

1431

Proximity Label-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

129

CUL3

8452

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

130

ERAL1

Affinity Capture-MS

Homo sapiens

131

RMND1

55005

Proximity Label-MS

Homo sapiens

132

B4galt1

Affinity Capture-MS

Mus musculus

133

HNRNPA1

3178

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

134

DHX30

22907

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

135

MYC

Affinity Capture-MS

Homo sapiens

136

Ect2

Affinity Capture-MS

Mus musculus

137

MRPS28

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

138

C12orf65

Proximity Label-MS

Homo sapiens

139

MYCN

Affinity Capture-MS

Homo sapiens

140

CEP250

11190

Affinity Capture-MS

Homo sapiens

141

DCUN1D1

54165

Affinity Capture-MS

Homo sapiens

142

MTG1

Proximity Label-MS

Homo sapiens

143

PSPC1

55269

Affinity Capture-MS

Homo sapiens

144

CSNK2A2

1459

Affinity Capture-MS

Homo sapiens

145

TSFM

10102

Proximity Label-MS

Homo sapiens

146

ACAD9

28976

Proximity Label-MS

Homo sapiens

147

VWA8

23078

Proximity Label-MS

Homo sapiens

148

USHBP1

Two-hybrid

Homo sapiens

149

MRPS17

51373

Affinity Capture-MS

Homo sapiens

150

METTL15

Proximity Label-MS

Homo sapiens

151

MCUR1

63933

Proximity Label-MS

Homo sapiens

152

DDX55

Affinity Capture-MS

Homo sapiens

153

SOX2

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

154

ZNF574

Affinity Capture-MS

Homo sapiens

155

DNAJC4

Proximity Label-MS

Homo sapiens

156

CLPP

8192

Proximity Label-MS

Homo sapiens

157

DNAJC28

Proximity Label-MS

Homo sapiens

158

FN1

2335

Affinity Capture-MS

Homo sapiens

159

ZNF707

Affinity Capture-MS

Homo sapiens

160

C8orf33

65265

Affinity Capture-MS

Homo sapiens

161

C17orf80

55028

Proximity Label-MS

Homo sapiens

162

FBXW11

Affinity Capture-MS

Homo sapiens

163

METTL17

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

164

AUH

549

Proximity Label-MS

Homo sapiens

165

TP53

7157

Affinity Capture-MS

Homo sapiens

166

TBRG4

9238

Proximity Label-MS

Homo sapiens

167

MRPL11

65003

Proximity Label-MS

Homo sapiens

168

DNAJC19

131118

Proximity Label-MS

Homo sapiens

169

MCAT

27349

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

170

MRPS2

51116

Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

171

RPL6

6128

Affinity Capture-MS

Homo sapiens

172

MTRF1L

Proximity Label-MS

Homo sapiens

173

ETV3

Proximity Label-MS

Homo sapiens

174

ICT1

3396

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

175

SOX15

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

176

ZNF746

Affinity Capture-MS

Homo sapiens

177

POLR1C

9533

Two-hybrid

Homo sapiens

178

MRPS18C

Affinity Capture-MS

Homo sapiens

179

MRPS31

Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

180

TUBGCP3

10426

Affinity Capture-MS

Homo sapiens

181

DNAJA3

9093

Proximity Label-MS

Homo sapiens

182

SMURF1

57154

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

183

MRPS15

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

184

ZBTB2

57621

Affinity Capture-MS

Homo sapiens

185

COX8A

Proximity Label-MS

Homo sapiens

186

MRPS10

55173

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

187

C21orf33

Proximity Label-MS

Homo sapiens

188

MRPS21

Affinity Capture-MS

Homo sapiens

189

SSBP1

6742

Proximity Label-MS

Homo sapiens

190

TMEM70

Proximity Label-MS

Homo sapiens

191

UFL1

23376

Affinity Capture-MS

Homo sapiens

192

FASTKD3

Proximity Label-MS

Homo sapiens

193

GID4

Affinity Capture-MS

Homo sapiens

194

NEIL1

Affinity Capture-MS

Homo sapiens

195

LONP1

9361

Proximity Label-MS

Homo sapiens

196

MRPS18B

28973

Affinity Capture-MS

Homo sapiens

197

GFM1

85476

Proximity Label-MS

Homo sapiens

198

HNRNPL

3191

Affinity Capture-MS

Homo sapiens

199

EIF4B

1975

Affinity Capture-MS

Homo sapiens

200

TEFM

Proximity Label-MS

Homo sapiens

201

MRPS9

64965

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

202

C19orf52

Proximity Label-MS

Homo sapiens

203

MGME1

Affinity Capture-MS

Homo sapiens

204

AP4M1

9179

Affinity Capture-MS

Homo sapiens

205

RPUSD3

Proximity Label-MS

Homo sapiens

206

HNRNPA1L2

144983

Affinity Capture-MS

Homo sapiens

207

TRMT10B

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

208

MRPS16

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

209

GRSF1

2926

Proximity Label-MS

Homo sapiens

210

C1QBP

708

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

211

PPAN

56342

Affinity Capture-MS

Homo sapiens

212

SMURF2

64750

Affinity Capture-MS

Homo sapiens

213

ZNF331

Affinity Capture-MS

Homo sapiens

214

MRPS22

56945

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

215

SP7

Proximity Label-MS

Homo sapiens

216

STRBP

55342

Affinity Capture-MS

Homo sapiens

217

DDX28

Proximity Label-MS

Homo sapiens

218

RPL17

6139

Affinity Capture-MS

Homo sapiens

219

PSMD3

5709

Co-fractionation

Homo sapiens

View the network

Pathways in which MRPS23 is involved

Pathway	Evidence	Source
Metabolism of proteins	TAS	Reactome
Metabolism of proteins	IEA	Reactome
Mitochondrial translation	TAS	Reactome
Mitochondrial translation	IEA	Reactome
Mitochondrial translation elongation	TAS	Reactome
Mitochondrial translation elongation	IEA	Reactome
Mitochondrial translation initiation	IEA	Reactome
Mitochondrial translation termination	TAS	Reactome
Translation	TAS	Reactome
Translation	IEA	Reactome

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