Gene description for SUPV3L1
Gene name suppressor of var1, 3-like 1 (S. cerevisiae)
Gene symbol SUPV3L1
Other names/aliases SUV3
Species Homo sapiens
 Database cross references - SUPV3L1
ExoCarta ExoCarta_6832
Vesiclepedia VP_6832
Entrez Gene 6832
HGNC 11471
MIM 605122
UniProt Q8IYB8  
 SUPV3L1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SUPV3L1
Molecular Function
    DNA binding GO:0003677 IMP
    DNA helicase activity GO:0003678 IMP
    DNA clamp loader activity GO:0003689 IEA
    RNA binding GO:0003723 HDA
    RNA helicase activity GO:0003724 IDA
    double-stranded RNA binding GO:0003725 IDA
    helicase activity GO:0004386 TAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IEA
    3'-5' RNA helicase activity GO:0034458 EXP
    3'-5' RNA helicase activity GO:0034458 IDA
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IPI
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
Biological Process
    mitochondrial RNA catabolic process GO:0000957 TAS
    mitochondrial mRNA catabolic process GO:0000958 IMP
    positive regulation of mitochondrial RNA catabolic process GO:0000962 IDA
    positive regulation of mitochondrial RNA catabolic process GO:0000962 IMP
    mitochondrial RNA 3'-end processing GO:0000965 IBA
    mitochondrial RNA 3'-end processing GO:0000965 IMP
    DNA recombination GO:0006310 IMP
    chromatin remodeling GO:0006338 IEA
    RNA catabolic process GO:0006401 IMP
    mitochondrion organization GO:0007005 IMP
    positive regulation of cell growth GO:0030307 IMP
    DNA duplex unwinding GO:0032508 IMP
    mitochondrial ncRNA surveillance GO:0035945 IMP
    mitochondrial mRNA surveillance GO:0035946 IMP
    negative regulation of apoptotic process GO:0043066 IMP
    chromatin looping GO:0140588 IEA
    mitochondrial RNA surveillance GO:2000827 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 IDA
    mitochondrial matrix GO:0005759 TAS
    mitochondrial nucleoid GO:0042645 IDA
    mitochondrial degradosome GO:0045025 IBA
    mitochondrial degradosome GO:0045025 IDA
 Experiment description of studies that identified SUPV3L1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SUPV3L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MRPS27 23107
Affinity Capture-MS Homo sapiens
2 AFG3L2 10939
Affinity Capture-MS Homo sapiens
3 HNRNPC 3183
Affinity Capture-MS Homo sapiens
4 BIRC6 57448
Affinity Capture-MS Homo sapiens
5 ZNF346  
Affinity Capture-MS Homo sapiens
6 ANLN 54443
Affinity Capture-MS Homo sapiens
7 ZNF703  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TRUB2  
Proximity Label-MS Homo sapiens
9 USP9X 8239
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 HNRNPCL1 343069
Affinity Capture-MS Homo sapiens
11 RPUSD4 84881
Proximity Label-MS Homo sapiens
12 MTRF1  
Proximity Label-MS Homo sapiens
13 ILF2 3608
Affinity Capture-MS Homo sapiens
14 HNRNPUL2 221092
Affinity Capture-MS Homo sapiens
15 MRPS18C  
Affinity Capture-MS Homo sapiens
16 EIF4ENIF1 56478
Two-hybrid Homo sapiens
17 IGF2BP3 10643
Affinity Capture-MS Homo sapiens
18 TFAM 7019
Proximity Label-MS Homo sapiens
19 RBM3 5935
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 PMPCA 23203
Proximity Label-MS Homo sapiens
21 INPP1 3628
Co-fractionation Homo sapiens
22 MAGEB6  
Two-hybrid Homo sapiens
23 YARS2  
Affinity Capture-MS Homo sapiens
24 HINT2 84681
Proximity Label-MS Homo sapiens
25 MRPS23 51649
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 BHLHA15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 MCTS1 28985
Affinity Capture-MS Homo sapiens
28 MRPS26 64949
Proximity Label-MS Homo sapiens
29 EXD2  
Proximity Label-MS Homo sapiens
30 ERAL1  
Affinity Capture-MS Homo sapiens
31 SERF2 10169
Affinity Capture-MS Homo sapiens
32 SSBP1 6742
Proximity Label-MS Homo sapiens
33 MYCN  
Affinity Capture-MS Homo sapiens
34 RBM42  
Affinity Capture-MS Homo sapiens
35 FASTKD2  
Proximity Label-MS Homo sapiens
36 VWA8 23078
Proximity Label-MS Homo sapiens
37 WASF3 10810
Affinity Capture-MS Homo sapiens
38 FAM120A 23196
Affinity Capture-MS Homo sapiens
39 MTERF3  
Proximity Label-MS Homo sapiens
40 LIN28A  
Affinity Capture-MS Homo sapiens
41 MDH2 4191
Proximity Label-MS Homo sapiens
42 ZMAT3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 MRPS25 64432
Affinity Capture-MS Homo sapiens
44 CDKN2AIP  
Affinity Capture-MS Homo sapiens
45 C6orf203  
Proximity Label-MS Homo sapiens
46 FASTKD5  
Proximity Label-MS Homo sapiens
47 PARK2  
Affinity Capture-MS Homo sapiens
48 MRPS34 65993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 SRSF3 6428
Affinity Capture-MS Homo sapiens
50 TUFM 7284
Proximity Label-MS Homo sapiens
51 NTRK1 4914
Affinity Capture-MS Homo sapiens
52 MRPS6  
Affinity Capture-MS Homo sapiens
53 HMGA2 8091
Affinity Capture-MS Homo sapiens
54 GFM1 85476
Proximity Label-MS Homo sapiens
55 DDX54 79039
Affinity Capture-MS Homo sapiens
56 MRPL11 65003
Proximity Label-MS Homo sapiens
57 MTRF1L  
Proximity Label-MS Homo sapiens
58 MRPL2 51069
Affinity Capture-MS Homo sapiens
59 ELAVL2 1993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 HNRNPDL 9987
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 MRRF  
Proximity Label-MS Homo sapiens
62 MRPS12  
Proximity Label-MS Homo sapiens
63 MTIF2 4528
Proximity Label-MS Homo sapiens
64 PNPT1 87178
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 RBM47 54502
Affinity Capture-MS Homo sapiens
66 MRPS11  
Affinity Capture-MS Homo sapiens
67 MTIF3  
Proximity Label-MS Homo sapiens
68 CUL3 8452
Affinity Capture-MS Homo sapiens
69 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 DHX30 22907
Proximity Label-MS Homo sapiens
71 C12orf65  
Proximity Label-MS Homo sapiens
72 PRR3  
Affinity Capture-MS Homo sapiens
73 TNFAIP6 7130
Affinity Capture-MS Homo sapiens
74 MYC  
Affinity Capture-MS Homo sapiens
75 ANPEP 290
Co-fractionation Homo sapiens
76 HNRNPH2 3188
Affinity Capture-MS Homo sapiens
77 MRPS17 51373
Affinity Capture-MS Homo sapiens
78 RBMS2 5939
Affinity Capture-MS Homo sapiens
79 SOX2  
Affinity Capture-MS Homo sapiens
80 PAIP1 10605
Affinity Capture-MS Homo sapiens
81 CLPP 8192
Proximity Label-MS Homo sapiens
82 CS 1431
Proximity Label-MS Homo sapiens
83 TSFM 10102
Proximity Label-MS Homo sapiens
84 AUH 549
Proximity Label-MS Homo sapiens
85 MRPS2 51116
Affinity Capture-MS Homo sapiens
86 ICT1 3396
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
87 LRPPRC 10128
Proximity Label-MS Homo sapiens
88 PDHA1 5160
Proximity Label-MS Homo sapiens
89 LZTS2 84445
Two-hybrid Homo sapiens
90 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
91 COX8A  
Proximity Label-MS Homo sapiens
92 C21orf33  
Proximity Label-MS Homo sapiens
93 WIF1 11197
Affinity Capture-MS Homo sapiens
94 C20orf197  
Affinity Capture-MS Homo sapiens
95 RBFOX2 23543
Two-hybrid Homo sapiens
96 MRPS18B 28973
Affinity Capture-MS Homo sapiens
97 TBRG4 9238
Proximity Label-MS Homo sapiens
98 AARS2  
Proximity Label-MS Homo sapiens
99 ARRB1 408
Co-fractionation Homo sapiens
100 DDX28  
Proximity Label-MS Homo sapiens
101 SRSF7 6432
Affinity Capture-MS Homo sapiens
102 HNRNPF 3185
Affinity Capture-MS Homo sapiens
103 GRSF1 2926
Proximity Label-MS Homo sapiens
104 C1QBP 708
Proximity Label-MS Homo sapiens
105 SERBP1 26135
Affinity Capture-MS Homo sapiens
106 KRAS 3845
Negative Genetic Homo sapiens
107 HNRNPU 3192
Affinity Capture-MS Homo sapiens
108 METTL17  
Proximity Label-MS Homo sapiens
109 ZMAT4  
Affinity Capture-MS Homo sapiens
110 RPA3 6119
Proximity Label-MS Homo sapiens
111 MRPS9 64965
Affinity Capture-MS Homo sapiens
112 CDC5L 988
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SUPV3L1 is involved
PathwayEvidenceSource
Metabolism of RNA TAS Reactome
Mitochondrial RNA degradation TAS Reactome





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