Gene description for INPP1
Gene name inositol polyphosphate-1-phosphatase
Gene symbol INPP1
Other names/aliases -
Species Homo sapiens
 Database cross references - INPP1
ExoCarta ExoCarta_3628
Entrez Gene 3628
HGNC 6071
MIM 147263
UniProt P49441  
 INPP1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Thymus 23844026    
 Gene ontology annotations for INPP1
Molecular Function
    metal ion binding GO:0046872 IEA
    inositol-1,3,4-trisphosphate 1-phosphatase activity GO:0052829 TAS
    inositol-1,4-bisphosphate 1-phosphatase activity GO:0004441 TAS
Biological Process
    small molecule metabolic process GO:0044281 TAS
    phosphate-containing compound metabolic process GO:0006796 TAS
    phosphatidylinositol phosphorylation GO:0046854 IEA
    dephosphorylation GO:0016311 TAS
    inositol phosphate metabolic process GO:0043647 TAS
    signal transduction GO:0007165 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified INPP1 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for INPP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which INPP1 is involved
PathwayEvidenceSource
Synthesis of IP2, IP, and Ins in the cytosol TAS Reactome





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