Gene description for NDC80
Gene name	NDC80 kinetochore complex component
Gene symbol	NDC80
Other names/aliases	HEC HEC1 HsHec1 KNTC2 TID3 hsNDC80
Species	Homo sapiens
Database cross references - NDC80
ExoCarta	ExoCarta_10403
Vesiclepedia	VP_10403
Entrez Gene	10403
HGNC	16909
MIM	607272
UniProt	O14777
NDC80 identified in sEVs derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for NDC80

Molecular Function     protein binding GO:0005515 IPI     microtubule binding GO:0008017 IMP     cyclin binding GO:0030332 IEA     identical protein binding GO:0042802 IPI     kinetochore adaptor activity GO:0140483 IDA Biological Process     mitotic sister chromatid segregation GO:0000070 TAS     establishment of mitotic spindle orientation GO:0000132 IMP     mitotic cell cycle GO:0000278 TAS     mitotic spindle organization GO:0007052 IMP     spindle assembly involved in female meiosis I GO:0007057 IEA     chromosome segregation GO:0007059 IMP     chromosome segregation GO:0007059 NAS     mitotic spindle assembly checkpoint signaling GO:0007094 NAS     G2/MI transition of meiotic cell cycle GO:0008315 IEA     attachment of spindle microtubules to kinetochore GO:0008608 IDA     attachment of spindle microtubules to kinetochore GO:0008608 IMP     skeletal muscle satellite cell proliferation GO:0014841 IEA     regulation of protein stability GO:0031647 IEA     centrosome duplication GO:0051298 IDA     cell division GO:0051301 IEA     metaphase chromosome alignment GO:0051310 IDA     metaphase chromosome alignment GO:0051310 IMP     attachment of mitotic spindle microtubules to kinetochore GO:0051315 IBA     attachment of mitotic spindle microtubules to kinetochore GO:0051315 IDA     attachment of mitotic spindle microtubules to kinetochore GO:0051315 IMP     kinetochore organization GO:0051383 IEA     positive regulation of mitotic cell cycle spindle assembly checkpoint GO:0090267 IMP Subcellular Localization     chromosome, centromeric region GO:0000775 TAS     kinetochore GO:0000776 IDA     kinetochore GO:0000776 NAS     outer kinetochore GO:0000940 IDA     nucleus GO:0005634 TAS     nucleoplasm GO:0005654 IDA     centrosome GO:0005813 IDA     cytosol GO:0005829 TAS     membrane GO:0016020 HDA     Ndc80 complex GO:0031262 IBA     Ndc80 complex GO:0031262 IDA     Ndc80 complex GO:0031262 IPI