Gene description for MYCBP
Gene name MYC binding protein
Gene symbol MYCBP
Other names/aliases AMY-1
Species Homo sapiens
 Database cross references - MYCBP
ExoCarta ExoCarta_26292
Vesiclepedia VP_26292
Entrez Gene 26292
HGNC 7554
MIM 606535
UniProt Q99417  
 MYCBP identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
 Gene ontology annotations for MYCBP
Molecular Function
    transcription coactivator activity GO:0003713 IBA
    transcription coactivator activity GO:0003713 IDA
    protein binding GO:0005515 IPI
Biological Process
    regulation of DNA-templated transcription GO:0006355 IBA
    regulation of DNA-templated transcription GO:0006355 IDA
    spermatogenesis GO:0007283 IEP
    positive regulation of DNA-templated transcription GO:0045893 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified MYCBP in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MYCBP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PA2G4 5036
Co-fractionation Homo sapiens
2 RNF34  
Affinity Capture-MS Homo sapiens
3 UBB 7314
Affinity Capture-MS Homo sapiens
4 PTN  
Two-hybrid Homo sapiens
5 UBE2H 7328
Affinity Capture-MS Homo sapiens
6 SPICE1  
Affinity Capture-MS Homo sapiens
7 SNX27 81609
Affinity Capture-MS Homo sapiens
8 ARFGEF2 10564
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 FBXW11  
Affinity Capture-MS Homo sapiens
10 KNSTRN  
Affinity Capture-MS Homo sapiens
11 Arhgap33  
Affinity Capture-MS Mus musculus
12 DYNLL2 140735
Affinity Capture-MS Homo sapiens
13 PARP1 142
Cross-Linking-MS (XL-MS) Homo sapiens
14 MECOM 2122
Affinity Capture-MS Homo sapiens
15 SUPT5H 6829
Affinity Capture-MS Homo sapiens
16 PREX1  
Affinity Capture-MS Homo sapiens
17 Akap8  
Affinity Capture-MS Mus musculus
18 POTEF 728378
Affinity Capture-MS Homo sapiens
19 Knstrn  
Affinity Capture-MS Mus musculus
20 TPT1 7178
Co-fractionation Homo sapiens
21 RC3H2  
Affinity Capture-MS Homo sapiens
22 CPEB1  
Proximity Label-MS Homo sapiens
23 OCRL 4952
Affinity Capture-MS Homo sapiens
24 KDM3A  
Affinity Capture-MS Homo sapiens
25 TSPYL5  
Affinity Capture-MS Homo sapiens
26 AURKA 6790
Affinity Capture-MS Homo sapiens
27 SELO 83642
Affinity Capture-MS Homo sapiens
28 ALG13 79868
Affinity Capture-MS Homo sapiens
29 VRK3 51231
Affinity Capture-MS Homo sapiens
30 GDF9 2661
Two-hybrid Homo sapiens
31 ZZEF1 23140
Co-fractionation Homo sapiens
32 PRKCZ 5590
Affinity Capture-MS Homo sapiens
33 EIF5A2 56648
Co-fractionation Homo sapiens
34 UBE3A 7337
Reconstituted Complex Homo sapiens
35 UBC 7316
Reconstituted Complex Homo sapiens
36 EGFR 1956
Affinity Capture-MS Homo sapiens
37 DAXX  
Affinity Capture-MS Homo sapiens
38 FARP2 9855
Affinity Capture-MS Homo sapiens
39 SUPT4H1  
Affinity Capture-MS Homo sapiens
40 DPP7 29952
Co-fractionation Homo sapiens
41 PARK7 11315
Affinity Capture-MS Homo sapiens
42 ASXL1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
43 CORO1C 23603
Co-fractionation Homo sapiens
44 REPIN1  
Co-fractionation Homo sapiens
45 PTCHD2  
Two-hybrid Homo sapiens
46 MAPRE1 22919
Affinity Capture-MS Homo sapiens
47 MAATS1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
48 OTUD4P1  
Affinity Capture-MS Homo sapiens
49 AKAP8  
Affinity Capture-MS Homo sapiens
50 KIAA1429 25962
Affinity Capture-MS Homo sapiens
51 HIST1H3E 8353
Affinity Capture-MS Homo sapiens
52 CAPZB 832
Affinity Capture-MS Homo sapiens
53 AGO4  
Affinity Capture-MS Homo sapiens
54 OTUD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 HEXIM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 MYC  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
57 ARHGAP36  
Affinity Capture-MS Homo sapiens
58 ARHGAP4 393
Affinity Capture-MS Homo sapiens
59 PLEKHG7  
Affinity Capture-MS Homo sapiens
60 COPS6 10980
Two-hybrid Homo sapiens
61 CFL1 1072
Two-hybrid Homo sapiens
62 SPEF2 79925
Affinity Capture-MS Homo sapiens
63 EIF3B 8662
Cross-Linking-MS (XL-MS) Homo sapiens
64 BRD1 23774
Affinity Capture-MS Homo sapiens
65 MYCN  
Affinity Capture-MS Homo sapiens
66 SYDE2  
Affinity Capture-MS Homo sapiens
67 YWHAQ 10971
Affinity Capture-MS Homo sapiens
68 SPAG5 10615
Affinity Capture-MS Homo sapiens
69 ENO1 2023
Cross-Linking-MS (XL-MS) Homo sapiens
70 EIF5AL1 143244
Co-fractionation Homo sapiens
71 ACTR1A 10121
Co-fractionation Homo sapiens
72 CDY2A  
Affinity Capture-MS Homo sapiens
73 ARFGEF1 10565
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 RC3H1 149041
Affinity Capture-MS Homo sapiens
75 NDC80 10403
Affinity Capture-MS Homo sapiens
76 SSRP1 6749
Two-hybrid Homo sapiens
77 MYCBPAP 84073
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
78 ARHGEF40 55701
Two-hybrid Homo sapiens
79 AKAP1 8165
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
80 DYNLL1 8655
Affinity Capture-MS Homo sapiens
81 KDM5A  
Affinity Capture-MS Homo sapiens
82 KDM1A 23028
Proximity Label-MS Homo sapiens
83 MORF4L1  
Affinity Capture-MS Homo sapiens
84 UROD 7389
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which MYCBP is involved
No pathways found





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