Gene description for ARFGEF2
Gene name	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Gene symbol	ARFGEF2
Other names/aliases	BIG2 PVNH2 dJ1164I10.1
Species	Homo sapiens
Database cross references - ARFGEF2
ExoCarta	ExoCarta_10564
Entrez Gene	10564
HGNC	15853
MIM	605371
UniProt	Q9Y6D5
ARFGEF2 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Endothelial cells	26027894

Gene ontology annotations for ARFGEF2

Molecular Function     protein binding GO:0005515 IPI     GABA receptor binding GO:0050811 ISS     ARF guanyl-nucleotide exchange factor activity GO:0005086 IDA     guanyl-nucleotide exchange factor activity GO:0005085 IDA     protein kinase A regulatory subunit binding GO:0034237 IDA     myosin binding GO:0017022 IEA Biological Process     protein transport GO:0015031 IEA     receptor recycling GO:0001881 IDA     intracellular signal transduction GO:0035556 IDA     endomembrane system organization GO:0010256 IMP     positive regulation of tumor necrosis factor production GO:0032760 IMP     exocytosis GO:0006887 IEA     Golgi to plasma membrane transport GO:0006893 IMP     endosome organization GO:0007032 IMP     positive regulation of GTPase activity GO:0043547 IEA Subcellular Localization     perinuclear region of cytoplasm GO:0048471 IEA     cytoplasmic membrane-bounded vesicle GO:0016023 IEA     Golgi membrane GO:0000139 IDA     cytoplasmic vesicle GO:0031410 ISS     cytosol GO:0005829 IDA     membrane GO:0016020 IDA     symmetric synapse GO:0032280 ISS     trans-Golgi network GO:0005802 ISS     axonemal microtubule GO:0005879 ISS     asymmetric synapse GO:0032279 ISS     cell junction GO:0030054 IEA     dendritic spine GO:0043197 ISS     microtubule organizing center GO:0005815 IDA     recycling endosome GO:0055037 IDA